Results 141 to 150 of about 1,204 (151)
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Bioorganic & Medicinal Chemistry Letters, 1992
Abstract A series of substituted benzimidazoles, especially albendazole and its oxodidized derivatives, have been prepared with pendant carboxylic acid functional groups attached to three different positions of the benzimidazole ring. The acids were converted to reactive esters with 3-hydroxysuccinimide and DCC and coupled to proteins.
Michael E. Mount +3 more
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Abstract A series of substituted benzimidazoles, especially albendazole and its oxodidized derivatives, have been prepared with pendant carboxylic acid functional groups attached to three different positions of the benzimidazole ring. The acids were converted to reactive esters with 3-hydroxysuccinimide and DCC and coupled to proteins.
Michael E. Mount +3 more
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Pharmacokinetics of albendazole, albendazole sulfoxide and netobimin in goats
Journal of Veterinary Pharmacology and Therapeutics, 1993H A, Benchaoui +2 more
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[Preparation of albendazole sulfoxide--- an active metabolite]
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciencesOBJECTIVE: To investigate the facile method for preparation of albendazole sulfoxide, an active metabolite in vivo. METHODS: The reaction condition was investigated according to evaluations to the results of the experiment through temperature, solvent, oxidation agent, reaction time and impurity.
Jian-Hua, Xie, Yong-Zhou, Hu
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Chromatographia, 1998
Reversed phase HPLC methods for the determination of two metabolites of albendazole in cow's milk are described. Albendazole is an anthelmintic agent used both in veterinary and human practice. Its main metabolites are albendazole-sulfoxide and albendazole-sulfone. The separation of the two metabolites was performed on a μ-Bondapak C-18 column using an
Zs. Romvári +5 more
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Reversed phase HPLC methods for the determination of two metabolites of albendazole in cow's milk are described. Albendazole is an anthelmintic agent used both in veterinary and human practice. Its main metabolites are albendazole-sulfoxide and albendazole-sulfone. The separation of the two metabolites was performed on a μ-Bondapak C-18 column using an
Zs. Romvári +5 more
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Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1992
Mebendazole (Meb), albendazole (Alb) or albendazole sulfoxide (AlbSO) were taken rapidly in vitro by secondary cysts of Echinococcus granulosus removed out from mice infected with protoscoleces 8-9 months previously. The amounts of the drugs taken by the cysts were apparently increased followed by exposure of the cysts to the drugs at 10 micrograms.ml ...
J Q, You, S H, Xiao, H F, Guo, P Y, Jiao
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Mebendazole (Meb), albendazole (Alb) or albendazole sulfoxide (AlbSO) were taken rapidly in vitro by secondary cysts of Echinococcus granulosus removed out from mice infected with protoscoleces 8-9 months previously. The amounts of the drugs taken by the cysts were apparently increased followed by exposure of the cysts to the drugs at 10 micrograms.ml ...
J Q, You, S H, Xiao, H F, Guo, P Y, Jiao
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Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1991
Mice infected with protoscoleces of Echinococcus granulosus for 8-9 months were treated ig with mebendazole (Meb) 50 mg.kg-1.d-1, albendazole (Alb) 300 mg.kg-1.d-1 or albendazole sulfoxide (AlbSO) 150 mg.kg-1.d-1 for 1-7 d. The glycogen contents of cyst wall in each drug groups were 1.0 +/- 0.6 - 1.8 +/- 0.9 mg/g, 1.1 +/- 0.9 - 1.8 +/- 0.8 mg/g and 0.8
S H, Xiao +6 more
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Mice infected with protoscoleces of Echinococcus granulosus for 8-9 months were treated ig with mebendazole (Meb) 50 mg.kg-1.d-1, albendazole (Alb) 300 mg.kg-1.d-1 or albendazole sulfoxide (AlbSO) 150 mg.kg-1.d-1 for 1-7 d. The glycogen contents of cyst wall in each drug groups were 1.0 +/- 0.6 - 1.8 +/- 0.9 mg/g, 1.1 +/- 0.9 - 1.8 +/- 0.8 mg/g and 0.8
S H, Xiao +6 more
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EFFICACY OF THE DRUG BASED ON ALBENDAZOLE SULFOXIDE IN CASE OF OVINE HELMINTHIASES
BULLETIN OF VETERINARY PHARMACOLOGY, 2023Orobets Vladimir Aleksandrovich +2 more
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