Results 111 to 120 of about 1,044,683 (223)

Exosomes in Cancer: The Biology, Function, Diagnosis, and Therapy

MedComm, Volume 7, Issue 11, November 2026.
Tumor‐derived exosomes and nonmembranous extracellular nanoparticles (exomeres/supermeres) constitute a heterogeneous communication network that drives cancer progression. By shuttling functional biomolecules across tissue‐specific barriers, these nanoparticles orchestrate local microenvironmental remodeling, immune suppression, premetastatic niche ...
Jun Wu, Lei Wu, Kang Yang, Kang Xie, Tao Lu, Tiangxiang Huang, Dengfeng Wan, Tao Song, Longbo Zhang   +8 more
wiley   +1 more source

Gastric Cancer: Epidemiology, Risk Factors, Pathogenesis, Clinical Features, Diagnosis, and Management

MedComm, Volume 7, Issue 11, November 2026.
This comprehensive review summarizes gastric cancer epidemiology, multifactorial risk factors (like infectious, dietary, genetic), pathogenesis such as precancerous evolution, molecular alterations, and a focus on the bidirectional interactions between gastric cancer cells and macrophages in the tumor microenvironment.
Yixuan Xin, Xingya Wang, Yangtao Wu, Qian Liu, Qian Ren, Hui Wang, Jingbo Zhai   +6 more
wiley   +1 more source

Engineering a 660 nm‐Responsive Optogenetic Inducer of Pyroptosis for Precision Cancer Therapy

Advanced Science, Volume 13, Issue 58, 19 October 2026.
This study reports a bioorthogonal pyroptosis inducer, PyroRACS. By using a red‐light‐responsive Cre‐On genetic switch to control the expression of highly cytotoxic GSDMDNT, PyroRACS enables the artificial induction of pyroptosis with precise spatiotemporal control.
Mengkai Zhang, Zhichao Li, Yonghao Ma, Yangyang Sun, Wei Chen, Weiren Huang   +5 more
wiley   +1 more source

Enhanced atherosclerosis molecular imaging and therapy with collagen hybridizing peptide functionalized albumin nanoparticles

Journal of Nanobiotechnology
Intraluminal drug coated devices, such as paclitaxel (PTX)-coated balloons, are commonly used to treat arterial occlusive diseases caused by atherosclerosis.
Jianan He, Jianxun Cai, Jingjing Zhang, Yang Li, Kunpeng Wei, Chenshu Liu, Leye Yan, Xinyan Hu, Lin Huang, Hairun Gan, Dashuai Wang, Bing Li, Huitao Zhang, Pengfei Pang   +13 more
doaj   +1 more source

Comparison of the efficacy and safety of programmed cell death protein 1 inhibitors combined with albumin-paclitaxel with or without platinum in the treatment of advanced metastasis or recurrent cervical cancer

Zhongguo linchuang yanjiu
Objective To compare the efficacy and safety of programmed cell death protein 1 (PD-1) inhibitor + albumin paclitaxel and platinum + PD-1 inhibitor + albumin-paclitaxel in the treatment of advanced metastasis or recurrent cervical cancer. Methods The
SHEN Jing*, XU Jingjing, LYU Mengmeng, WU Dongchen, WANG Jinhua
doaj   +1 more source

Five‐Year Survival Analyses on Non‐Pathological Complete Response Esophageal Squamous Cell Carcinoma Patients After Neoadjuvant Regimens Plus Surgery: A Propensity Score Matching, Real‐World Cohort Study

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Background Non‐pathological complete response (non‐pCR) is common in esophageal squamous cell carcinoma (ESCC) patients after neoadjuvant therapy, yet evidence guiding long‐term outcomes and postoperative risk stratification in the immunotherapy era remains limited.
Weibin Liu, Yujie Deng, Yan Lin, Yijin Lin, Xuejin Zheng, Weikun Su, Weijin Xiao, Yi Shi, Jiarong Zhang, Xiaohui Chen   +9 more
wiley   +1 more source

Interstitial Lung Disease Following Single-Agent Nanoparticle Albumin-Bound Paclitaxel Treatment in Patients with Advanced Non-Small Cell Lung Cancer

, 2017
Interstitial lung disease (ILD) is a serious and potentially fatal adverse event in lung cancer therapy. Nanoparticle albumin-bound paclitaxel (nab-PTX) is a novel, solvent-free formulation of paclitaxel (PTX).
Takayasu Kurata, Takayuki Miyara, Aya Nakaya, Kayoko Kibata, Takashi Yokoi, Naoko Satsutani, Yuki Takeyasu, Shosaku Nomura, Yuki Nakatani, Makoto Ogata, Maiko Niki   +10 more
core   +2 more sources

Increased Lymphocyte Proportions as a Candidate Biomarker for Immune‐Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitors and Chemotherapy

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Background Combination therapy comprising immune checkpoint inhibitors (ICIs) and chemotherapy is standard treatment for many cancer types. However, the management of adverse events (AEs) induced by combination therapy is more complicated than that of AEs induced by ICI monotherapy.
Nanami Ito, Yoshihiko Tasaki, Yosuke Sugiyama, Takehiro Uemura, Keisuke Yokota, Ryo Ogawa, Takaya Shimura, Daisuke Kawakita, Yumi Wanifuchi‐Endo, Yoshihisa Mimura, Moeko Iida, Kunihiro Odagiri, Yuka Kimura, Misato Tomita, Yuji Hotta, Tatsuya Toyama, Shinichi Iwasaki, Hiromi Kataoka, Shuji Takiguchi, Katsuhiro Okuda, Akio Niimi, Yoko Furukawa‐Hibi   +21 more
wiley   +1 more source

Neuro‐associated SEMA3C+ tumour cells promote gastric cancer peritoneal metastasis via EBF2–FGF7–FGFR2‐mediated tumour–endothelial crosstalk

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
Single‐nucleus sequencing identified a semaphorin 3C (SEMA3C)‐high stem‐like tumour subpopulation that drives gastric cancer peritoneal metastasis through early B‐cell factor 2 (EBF2)‐mediated FGF7 expression and enhanced FGF7–FGFR2 signalling with endothelial cells. Targeting the FGF–FGFR pathway may provide a promising therapeutic strategy.
Yajing Zhou, Chao Dong, Weikang Li, Minghao Sun, Qingyu Xie, Lixing Gu, Pengbo Wang, Chengxiang Xu, Tianzhan Gao, Caixin Zhu, Kaipeng Duan, Jin Zhou, Dongbao Li   +12 more
wiley   +1 more source

Nanoparticle Albumin-bound Paclitaxel Plus Carboplatin Induction Followed by Nanoparticle Albumin-bound Paclitaxel Maintenance in Squamous Non-Small-cell Lung Cancer (ABOUND.sqm): A Phase III Randomized Clinical Trial.

, 2020
BACKGROUND: We evaluated maintenance nanoparticle albumin-bound (nab) paclitaxel in the treatment of advanced squamous non-small-cell lung cancer. PATIENTS AND METHODS: Patients with treatment-naive squamous non-small-cell lung cancer received four 21 ...
West, Howard J, Gridelli, Cesare, Daniel, Davey, Bhore, Rafia, Aix, Santiago Ponce, Juan-Vidal, Oscar, Thomas, Michael, Chen, Tianlei, Ong, Teng Jin, Knoble, Jeanna, Page, Ray, McCleod, Michael, Spigel, David R, Morgensztern, Daniel, Wolfsteiner, Marianne, Jotte, Robert M, Gressot, Laurent, Socinski, Mark A, Reinmuth, Niels, Mileham, Kathryn F   +19 more
core   +1 more source