Results 51 to 60 of about 98,007 (336)

Health related effects of wheat varieties [PDF]

, 2020
Summarises the different effects wheat digestion has on human ...
Borgen, Anders
core  

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Binding of Oxovanadium(IV) Complexes to Blood Serum Albumins [PDF]

, 2013
In this work the binding of VIVO2+ and VIVO-complexes to serum albumins {human serum albumin (HSA), bovine serum albumin (BSA) and porcine serum albumin (PSA)} are studied using circular dichroism (CD), electron paramagnetic resonance (EPR) and ...
Cobbina, Enoch, Correia, Isabel, Enyedi, Éva, Jakusch, Tamás, Kiss, Tamás, Mehtab, Sameena   +5 more
core  

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Changes in Protein Composition in the Grain and Malt after Fusarium Infection Dependently of Wheat Resistance

Pathogens, 2019
The grain yield, as well as the quality and safety of the wheat grains and corresponding malt can be compromised by Fusarium spp. infection. The protein content of the grain affects the chemical composition and enzyme levels of the finished malt.
Valentina Spanic, Daniela Horvat, Georg Drezner, Zvonimir Zdunic   +3 more
doaj   +1 more source

Allosteric modulation of zinc speciation by fatty acids [PDF]

Background: Serum albumin is the major protein component of blood plasma and is responsible for the circulatory transport of a range of small molecules that include fatty acids, hormones, metal ions and drugs.
Barnett, James P., Dr., Blindauer, Claudia A., Kassaar, Omar, Khazaipoul, Siavash, Martin, Esther M., Sadler, P. J., Stewart, Alan J. S.   +6 more
core   +1 more source

The O-carbamoyl-transferase albis is responsible for the modification of albicidin [PDF]

, 2016
Albicidin is a potent antibiotic and phytotoxin produced by the sugarcane pathogenic bacterium Xanthomonas albilineans which targets the plant and bacterial DNA gyrase.[1] The infection occurs through the xylem vessels of the plants where the pathogen ...
Arasté, Julie, Cociancich, Stéphane, Hempel, Benjamin, Kerwat, Dennis, Marguerettaz, Mélanie, Pesic, Alexander, Petras, Daniel, Royer, Monique, Semsary, Siamak, Süssmuth, Roderich, Von Eckardstein, Leonard   +10 more
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

A new way of valorizing biomaterials: the use of sunflower protein for 1 a-tocopherol microencapsulation [PDF]

, 2013
Biopolymer based microparticles were efficiently prepared from sunflower protein (SP) wall material and a-tocopherol (T) active core using a spray-drying technique. Protein enzymatic hydrolysis and/or N-acylation were carried out to make some structural
A. Nesterenko, Aider, Augustin, Avaltroni, Benita, Burkus, Chabanon, Chanamai, Charve, Church, Daqiq, De Graaf, Dickinson, Dubey, Elizondo, F. Silvestre, F. Violleau, Faria, Favaro-Trindade, Fennema, Gharsallaoui, Glantz, Gonzalez-Perez, Gonzalez-Perez, Gonzalez-Perez, Goodno, Gouin, Guyomarc'h, I. Alric, Junyaprasert, Kang, Kawakatsu, Kong, Lamsal, Luo, Martinez, Matemu, Mo, Molina, Nesterenko, Nesterenko, Nunes, Ortiz, Patino, Pickardt, Pierucci, Rampon, Rascon, Rbii, Reiffers-Magnani, Robins, Rondel, Rusli, Salgado, V. Durrieu, Vastag, Vilkhu, Wang, Wong, Yohannes, Yoo, Yu, Yust, Zheng, Zorba   +64 more
core   +4 more sources