Results 61 to 70 of about 98,007 (336)

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

A nucleotide insertion and frameshift cause albumin Kénitra, an extended and O-glycosylated mutant of human serum albumin with two additional disulfide bridges [PDF]

, 2001
Albumin Kenitra is a new type of genetic variant of human serum albumin that has been found in two members of a family of Sephardic Jews from Kenitra (Morocco).
Campagnoli M, Cosulich ME, Disdier P, Galliano M., Granel B, Kragh Hansen U, Minchiotti L, MONTI, MARIA, PUCCI, PIETRO, Rossi A, Weiller PJ   +10 more
core   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Estudio electroforético de las albúminas y globulinas de cuatro genotipos de Canavalia ensiformis

Archivos Latinoamericanos de Nutrición, 2000
Para el estudio de las albúminas y globulinas de semillas de Canavalia ensiformis, se utilizaron la electroforesis en gel discontinuo de poliacrilamida (PAGE) y la electroforesis en gel discontinuo de poliacrilamida con dodecil sulfato de sodio (PAGE ...
Ligia Ortiz de Bertorelli, Alejandra Ramírez   +1 more
doaj  

HCAR score as a prognostic biomarker of survival in locally advanced nasopharyngeal carcinoma treated with concurrent chemoradiotherapy

Biomolecules & Biomedicine
Nasopharyngeal carcinoma (NPC) is an aggressive malignancy of the head and neck that is often diagnosed at a locally advanced stage (LANPC). In such cases, intensity-modulated radiotherapy combined with concurrent chemoradiotherapy (CCRT) is the ...
Erkan Topkan, Efsun Somay, Duriye Ozturk, Ugur Selek   +3 more
doaj   +1 more source

Sensing of Proteins by ICD Response of Iron(II) Clathrochelates Functionalized by Carboxyalkylsulfide Groups

Biomolecules, 2020
Recognition of elements of protein tertiary structure is crucial for biotechnological and biomedical tasks; this makes the development of optical sensors for certain protein surface elements important.
Mykhaylo Losytskyy, Nina Chornenka, Serhii Vakarov, Samuel M. Meier-Menches, Christopher Gerner, Slawomir Potocki, Vladimir B. Arion, Elzbieta Gumienna-Kontecka, Yan Voloshin, Vladyslava Kovalska   +9 more
doaj   +1 more source

Maize IgE binding proteins: each plant a different profile? [PDF]

, 2014
Background: Allergies are nearly always triggered by protein molecules and the majority of individuals with documented immunologic reactions to foods exhibit IgE hypersensitivity reactions.
Batista, Rita, Fonseca, Cátia, Oliveira, M. Margarida, Pinheiro, Carla, Planchon, Sébastien, Renaut, Jenny, Ricardo, Cândido   +6 more
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Biochemical blood parameters in platinum fox females and males in ontogenesis

Ветеринария сегодня
Currently, veterinarians pay much attention to the diagnostic examination of animals, including animals kept on fur farms. Blood is the main material used for such examinations.
I. I. Okulova, Yu. A. Berezina, A. S. Syutkina, I. A. Plotnikov, O. Yu. Bespyatykh, I. A. Domsky   +5 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source