Results 1 to 10 of about 4,496,597 (381)

ILC-OPI: impulsive lifestyle counselling versus cognitive behavioral therapy to improve retention of patients with opioid use disorders and externalizing behavior: study protocol for a multicenter, randomized, controlled, superiority trial

BMC Psychiatry, 2021
Background Substance use disorders show a high comorbidity with externalizing behavior difficulties, creating treatment challenges, including difficulties with compliance, a high risk of conflict, and a high rate of offending post-treatment.
Morten Hesse, Birgitte Thylstrup, Sidsel Helena Karsberg, Michael Mulbjerg Pedersen, Mads Uffe Pedersen   +4 more
doaj   +1 more source

Striatal D1 and D2 receptor availability are selectively associated with eye-blink rates after methylphenidate treatment

Communications Biology, 2022
PET imaging in human participants revealed that D1 and D2 dopamine receptor availability was associated with eye-blink rates following treatment with oral methylphenidate, but not a placebo.
Şükrü B. Demiral, Peter Manza, Erin Biesecker, Corinde Wiers, Ehsan Shokri-Kojori, Katherine McPherson, Evan Dennis, Allison Johnson, Dardo Tomasi, Gene-Jack Wang, Nora D. Volkow   +10 more
doaj   +1 more source

Group versus individual treatment for substance use disorders: a study protocol for the COMDAT trial

BMC Public Health, 2021
Background Alcohol and other drug use disorders contribute substantially to the global burden of illness. The majority of people with substance use disorders do not receive any treatment for their problems, and developing treatments that are attractive ...
Sidsel Helena Karsberg, Mads Uffe Pedersen, Morten Hesse, Birgitte Thylstrup, Michael Mulbjerg Pedersen   +4 more
doaj   +1 more source

Associations of clustered health risk behaviors with diabetes and hypertension in White, Black, Hispanic, and Asian American adults

BMC Public Health, 2022
Background The clustering of Big Four contributors to morbidity and mortality—alcohol misuse, smoking, poor diet, and physical inactivity—may further elevate chronic health risk, but there is limited information about their specific combinations and ...
Won Kim Cook, Libo Li, Christina C. Tam, Nina Mulia, William C. Kerr   +4 more
doaj   +1 more source

Challenges in maintaining treatment services for people who use drugs during the COVID-19 pandemic

Harm Reduction Journal, 2020
The impact of COVID-19 across health services, including treatment services for people who use drugs, is emerging but likely to have a high impact. Treatment services for people who use drugs provide essential treatment services including opiate agonist ...
Adrian Dunlop, Buddhima Lokuge, Debbie Masters, Marcia Sequeira, Peter Saul, Grace Dunlop, John Ryan, Michelle Hall, Nadine Ezard, Paul Haber, Nicholas Lintzeris, Lisa Maher   +11 more
doaj   +1 more source

Cortical D1 and D2 dopamine receptor availability modulate methylphenidate-induced changes in brain activity and functional connectivity

Communications Biology, 2022
Joint PET and MRI analyses of cortical D1 and D2 dopamine receptors in healthy adults provide a framework for understanding how dopamine-boosting drugs alter brain function.
Peter Manza, Ehsan Shokri-Kojori, Şükrü Barış Demiral, Corinde E. Wiers, Rui Zhang, Natasha Giddens, Katherine McPherson, Erin Biesecker, Evan Dennis, Allison Johnson, Dardo Tomasi, Gene-Jack Wang, Nora D. Volkow   +12 more
doaj   +1 more source

“Frustrated with the whole system”: a qualitative framework analysis of the issues faced by people accessing health services for chronic pain

BMC Health Services Research, 2022
Background Chronic non-cancer pain (CNCP) is complex and often requires multimodal management comprising of both pharmacological and non-pharmacological treatments.
Ria E. Hopkins, Louisa Degenhardt, Gabrielle Campbell, Sara Farnbach, Natasa Gisev   +4 more
doaj   +1 more source

Neural circuit selective for fast but not slow dopamine increases in drug reward

Nature Communications, 2023
The faster a drug enters the brain, the greater its addictive potential, yet the brain circuits underlying the rate dependency to drug reward remain unresolved.
Peter Manza, Dardo Tomasi, Ehsan Shokri-Kojori, Rui Zhang, Danielle Kroll, Dana Feldman, Katherine McPherson, Catherine Biesecker, Evan Dennis, Allison Johnson, Kai Yuan, Wen-Tung Wang, Michele-Vera Yonga, Gene-Jack Wang, Nora D. Volkow   +14 more
doaj   +1 more source

Formative process evaluation of a guideline-driven process for improving the cultural responsiveness of alcohol and drug treatment services

BMC Health Services Research, 2021
Background To improve Australian Aboriginal and Torres Strait Islander people’s access to, and experience of, healthcare services, including Alcohol and other Drug (AoD) treatment services, principles and frameworks have been developed to optimise ...
Sara Farnbach, Julaine Allan, Raechel Wallace, Alexandra Aiken, Anthony Shakeshaft   +4 more
doaj   +1 more source

Subcortical serotonin 5HT2c receptor-containing neurons sex-specifically regulate binge-like alcohol consumption, social, and arousal behaviors in mice

Nature Communications, 2023
The neurobiological mechanisms by which binge alcohol consumption disrupts social and emotional functioning are unknown. Here, the authors demonstrate that sex-specific social and arousal disturbances induced by binge alcohol consumption are driven by ...
M. E. Flanigan, O. J. Hon, S. D’Ambrosio, K. M. Boyt, L. Hassanein, M. Castle, H. L. Haun, M. M. Pina, T. L. Kash   +8 more
doaj   +1 more source