Results 71 to 80 of about 91,956 (289)

Can screening and brief intervention lead to population-level reductions in alcohol-related harm?

, 2012
A distinction is made between the clinical and public health justifications for screening and brief intervention (SBI) against hazardous and harmful alcohol consumption.
Nick Heather, Heather, Nick
core   +1 more source

The combined effect of smoking tobacco and drinking alcohol on cause-specific mortality: a 30 year cohort study [PDF]

, 2010
<p><b>Background:</b> Smoking and consuming alcohol are both related to increased mortality risk. Their combined effects on cause-specific mortality were investigated in a prospective cohort study.</p> <p><b>Methods:
Gruer, L., Gruer, L, Watt Graham CM, Carole L Hart, Davey Smith George, Hart, CL, Watt, G.C.M., George Davey Smith, Davey Smith, G., Hart, C.L., Davey Smith, G, Gruer Laurence, Hart Carole L, Laurence Gruer, Graham CM Watt   +14 more
core   +1 more source

Noninvasive tests for nonalcoholic fatty liver disease in a multi‐ethnic population: The HELIUS study

Hepatology Communications, EarlyView., 2022
Abstract Nonalcoholic fatty liver disease (NAFLD) is increasing in prevalence and severity globally, prompting noninvasive testing, yet limited data exist on noninvasive liver tests (NITs) including transient elastography (TE) in ethnically diverse populations.
Anne‐Marieke van Dijk, Yasaman Vali, Anne Linde Mak, Henrike Galenkamp, Max Nieuwdorp, Bert‐Jan van den Born, Adriaan Georgius Holleboom   +6 more
wiley   +1 more source

Adult consequences of late adolescent alcohol consumption: a systematic review of cohort studies. [PDF]

, 2011
BACKGROUND: Although important to public policy, there have been no rigorous evidence syntheses of the long-term consequences of late adolescent drinking.
McAlaney, J., McAlaney J., Rowe, Richard, McAlaney John, Rowe Richard, John McAlaney, McCambridge Jim, Rowe, R., McCambridge J., McCambridge, Jim, McAlaney, John, Jim McCambridge, Richard Rowe, McCambridge, J.   +13 more
core   +1 more source

Characteristics and Outcomes of Male Participants in a Multicenter Longitudinal Australian Study Cohort

Arthritis Care &Research, EarlyView.
Objective The aim of this study was to determine the differences in demographic, serologic, and clinical characteristics between male and female patients with systemic sclerosis (SSc) in an Australian cohort. Methods This was a retrospective observational study using data from the Australian Scleroderma Cohort Study.
Emily Lin, Dylan Hansen, Laura Ross, Gene‐Siew Ngian, Susanna Proudman, Gabor Major, Maryam Tabesh, Mandana Nikpour, Jennifer Walker, Lauren Host, Nava Ferdowsi, Alannah Quinlivan, Wendy Stevens, Joanne Sahhar, Diane Apostolopoulos   +14 more
wiley   +1 more source

Low sphingolipid levels predict poor survival in patients with alcohol-related liver disease

JHEP Reports
Background & Aims: Alcohol-related hepatitis (AH) and alcohol-related cirrhosis are grave conditions with poor prognoses. Altered hepatic lipid metabolism can impact disease development and varies between different alcohol-related liver diseases ...
Thit Mynster Kronborg, Qian Gao, Kajetan Trošt, Henriette Ytting, Malene Barfod O’Connell, Mikkel Parsberg Werge, Mira Thing, Lise Lotte Gluud, Ole Hamberg, Søren Møller, Thomas Moritz, Flemming Bendtsen, Nina Kimer   +12 more
doaj   +1 more source

LC3B Mediated SETDB1‐Accounted Alcoholic Steatohepatitis via Lipidation‐Dependent LAP and Lipidation‐Independent Nuclear Stabilization

Advanced Science, EarlyView.
SETDB1 is progressively downregulated in ALD, correlating with disease severity. SETDB1 deficiency impairs LAP by disrupting Rubicon membrane localization, leading to defective lipid droplet clearance. Concurrently, loss of SETDB1 reduces nuclear LC3B, causing R‐loop accumulation and cGAS‐STING‐driven inflammation. Lipidated LC3B mediates LAP‐dependent
Yi Zhang, Tan Wei, Jiahang Wu, Chuixu Lin, Dongbo Zhu, Yanhui Li, Shuting Shi, Shishun Huang, Leiming Jiang, Hongzhi Wang, Meiqi Song, Pengfei Gao, Xu Wu, Mingjian Fan, Chaofeng Wei, Qian Wang, Lihui Qu, Zhigang Wang   +17 more
wiley   +1 more source

Are the opportunities to prevent alcohol related liver deaths in the UK in primary or secondary care? A retrospective clinical review and prospective interview study

Substance Abuse Treatment, Prevention, and Policy, 2006
Background Deaths from liver cirrhosis have increased at least 8 fold since the 1970's in the UK and further increases are anticipated, whereas in the rest of Europe liver deaths are decreasing.
Sheron Nick, Smith Stewart, Verrill Clare   +2 more
doaj   +1 more source

Estimated central blood volume in cirrhosis [PDF]

, 1992
The estimated central blood volume (i.e., blood volume in the heart cavities, lungs and central arterial tree) was determined by multiplying cardiac output by circulatory mean transit time in 19 patients with cirrhosis and compared with sympathetic ...
Ring-Larsen, Helmer, Christensen, Niels Juel, Sørensen, Thorkild I. A., Henriksen, Jens H., Gerbes, Alexander L., Bendtsen, Flemming   +5 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source