Results 81 to 90 of about 91,956 (289)

Alcoholic liver cirrhosis, more than a simple hepatic disease – A brief review of the risk factors associated with alcohol abuse

Journal of Mind and Medical Sciences, 2019
Liver cirrhosis is a significant public health problem, being an important cause of mortality and morbidity, responsible for approximately 1.8% of the total number of deaths in Europe.
Sergiu Ioan Micu, Madalina Elena Manea, Roxana Popoiag, Dragana Nikolic, Dumitru Andrada, Angelo Maria Patti, Marilena Musat, Cristian Balalau, Anca Rogoveanu, Manfredi Rizzo, Anca Pantea Stoian   +10 more
doaj   +1 more source

Escherichia/Shigella, SCFAs, and Metabolic Pathways—The Triad That Orchestrates Intestinal Dysbiosis in Patients with Decompensated Alcoholic Cirrhosis from Western Mexico

Microorganisms, 2022
Gut microbiota undergoes profound alterations in alcohol cirrhosis. Microbiota-derived products, e.g., short chain fatty acids (SCFA), regulate the homeostasis of the gut-liver axis.
Tonatiuh Abimael Baltazar-Díaz, Luz Alicia González-Hernández, Juan Manuel Aldana-Ledesma, Marcela Peña-Rodríguez, Alejandra Natali Vega-Magaña, Adelaida Sara Minia Zepeda-Morales, Rocío Ivette López-Roa, Susana del Toro-Arreola, Erika Martínez-López, Adriana María Salazar-Montes, Miriam Ruth Bueno-Topete   +10 more
doaj   +1 more source

Serum microRNA-122 predicts survival in patients with liver cirrhosis

, 2012
Background: Liver cirrhosis is associated with high morbidity and mortality. MicroRNAs (miRs) circulating in the blood are an emerging new class of biomarkers.
Stefan Zeuzem, Albrecht Piiper (22854), Oliver Waidmann, Kronenberger, Bernd, Friederike Brunner, Verena Köberle (130993), Bernd Kronenberger (131004), Bernd Kronenberger, Verena Köberle, Waidmann, Oliver, Albrecht Piiper, Oliver Waidmann (130988), Piiper, Albrecht, Friederike Brunner (130998), Köberle, Verena, Brunner, Friederike, Zeuzem, Stefan, Stefan Zeuzem (22856)   +17 more
core   +1 more source

Targeting Endogenous Lipophagy: A Novel Strategy to Enhance MSC Osteogenesis and Mineralization for Senile Osteoporosis Therapy

Advanced Science, EarlyView.
Schematic representation of the role of lipophagy in bone mesenchymal stem cells(MSCs). In healthy MSCs, functional lipophagy efficiently degrades lipid droplets to support oxidative phosphorylation and cellular energy production, thereby facilitating osteogenic differentiation and matrix mineralization.
Chaoqiang Chen, Zhidong Liu, Yanhang Sun, Xiaojun Xu, Zhexiao Lan, Junhao Zhao, Peitao Xu, Guiwen Ye, Jinteng Li   +8 more
wiley   +1 more source

Master Regulator SMC1A, Stabilized by N6‐Methyladenosine Reader IGF2BP1, Promotes HCC Progression Through Facilitating Enhancer–Promoter Interaction of Nestin

Advanced Science, EarlyView.
IGF2BP1‐mediated m6A stabilization sustains SMC1A expression, enabling cohesin‐associated chromatin regulation of Nestin in hepatocellular carcinoma. This work reveals an epitranscriptomic‐chromatin‐cytoskeletal regulatory axis linked to malignant phenotypes and identifies SMC1A as a biologically relevant vulnerability in HCC.
Zhenxiang Peng, Diguang Wen, Lu Zeng, Lin Lv, Shengtao Liao, Wenguang Zhang, Zhechuan Mei, Chuanfei Li   +7 more
wiley   +1 more source

A case of diffuse large B‐cell lymphoma with decompensated alcohol‐related liver cirrhosis treated successfully by chemoimmunotherapy

Clinical Case Reports
Key Clinical Message This report describes a case of diffuse large B‐cell lymphoma with MYD88 L265P and KM2DT mutation and decompensated alcohol‐related liver cirrhosis.
Yan Li, Ling‐zhijie Kong
doaj   +1 more source

Hepatic osteodystrophy in cirrhosis due to alcohol-related liver disease

Revista Española de Enfermedades Digestivas, 2020
hepatic osteodystrophy, including osteoporosis, is an abnormal bone metabolism related with chronic liver diseases. Osteoporosis is associated with an increased risk of bone fractures, with a significant impact on morbidity, mortality and healthcare costs.
Flávio, Pereira, Richard, Azevedo, Marisa, Linhares, João, Pinto, Cátia, Leitão, Ana, Caldeira, José, Tristan, Eduardo, Pereira, Rui, Sousa, António, Banhudo   +9 more
openaire   +2 more sources

Alcohol’s burden of disease in Australia [PDF]

, 2014
Alcohol causes 15 deaths and hospitalises 430 Australians every day, according to this report. Summary Burden of Disease (BoD) estimates based on current health and alcohol consumption data are integral in conceptualising the impact of alcohol on the ...

core  

A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis [PDF]

, 2015
Alcohol misuse is the leading cause of cirrhosis and the second most common indication for liver transplantation in the Western world. We performed a genome-wide association study for alcohol-related cirrhosis in individuals of European descent (712 ...
Jacques Devière, Wolfgang Lieb, Stickel, Felix, Schmelz, Renate, Markus M Lerch, Josef Frank, Frank, Josef, Nothen, M, Mario Brosch, Christian Datz, Zeissig, Sebastian, Henry Völzke, Morgan, Marsha Y., David Ellinghaus, Hellerbrand, Claus, Felix Stickel, Hampe, Jochen, Franke, Andre, Ellinghaus, David, Michael Nothnagel, Pierre Deltenre, Clumeck, Nicolas, Lerch, Markus M., Michael Way, Nicolas Clumeck, Mayerle, Julia, Nöthen, Markus M, Frank Lammert, Nasser Semmo, Zopf, Steffen, Sven Cichon, Huse, Klaus, Berg, Thomas, Steffen Zopf, Nöthen, Markus M., Aigner, Elmar, Andrew McQuillin, Marsha Y Morgan, Brosch, Mario, Franchimont, Denis, Jochen Hampe, Nischalke, Hans Dieter, Stefan Brückner, Eric Trépo, Klaus Huse, Way, Michael, Renate Schmelz, Schreiber, Stefan, Lerch, Markus M, Christophe Moreno, Devière, Jacques, Julia Mayerle, Anna-Magdalena Stephan, Thomas Berg, Buch, Stephan, Enk, Alexander Herrmann, Stefan Schreiber, Stephan, Anna-Magdalena, Elmar Aigner, Eyer, Florian, Lieb, Wolfgang, Morgan, Marsha Yvonne, Moreno, Christophe, Marcella Rietschel, Trépo, Eric, Schafmayer, Clemens, Falk Kiefer, Thierry Gustot, Claus Hellerbrand, Völzke, Henry, Florian Eyer, Hans Dieter Nischalke, Clemens Schafmayer, McQuillin, Andrew, Sarrazin, Christoph, Datz, Christian, Lammert, Frank, Christoph Sarrazin, Monika Ridinger, Sebastian Zeissig, Rietschel, Marcella, Wodarz, Norbert, Ridinger, Monika, Stephan Buch, Brückner, Stefan, Markus M Nöthen, Cichon, Sven, Gustot, Thierry, Andre Franke, Rosendahl, Jonas, Michael Soyka, Norbert Wodarz, Denis Franchimont, Herrmann, Alexander, Soyka, Michael, Jonas Rosendahl, Semmo, Nasser, Alexander Herrmann, Kiefer, Falk, Deltenre, Pierre, Morgan, Marsha Y, Nothnagel, Michael   +101 more
core   +1 more source

Preoperative Total Iron‐Binding Capacity Is a Novel Surrogate Marker of Short‐ and Long‐Term Outcomes After Liver Resection for Hepatocellular Carcinoma

Annals of Gastroenterological Surgery, EarlyView.
HCC patients with low preoperative TIBC levels experienced significantly more frequent post‐hepatectomy complications. Furthermore, these patients were significantly correlated with worse survival. Preoperative serum TIBC levels may be a novel surrogate marker of postoperative complications and long‐term survival after hepatectomy.
Taishi Yamane, Hiromitsu Hayashi, Daisuke Ogawa, Shotaro Kinoshita, Yuta Shiraishi, Takanobu Yamao, Yuki Kitano, Tatsunori Miyata, Hirohisa Okabe, Masaaki Iwatsuki   +9 more
wiley   +1 more source