Results 11 to 20 of about 1,693,931 (269)

Adverse childhood events and risk of diabetes onset in the 1979 National longitudinal survey of youth cohort

BMC Public Health, 2019
Background Type 2 diabetes is a major public health problem with considerable personal and societal costs. Adverse childhood experiences (ACE) are associated with a number of serious and chronic health problems in adulthood, but these experiences have ...
E. Anne Lown, Camillia K. Lui, Kate Karriker-Jaffe, Nina Mulia, Edwina Williams, Yu Ye, Libo Li, Thomas K. Greenfield, William C. Kerr   +8 more
doaj   +1 more source

Protocol for a multi-centre, definitive randomised controlled trial of the effectiveness of Individual Placement and Support for employment support among people with alcohol and drug dependence

Trials, 2020
Background Unemployment is highly prevalent in populations with alcohol and drug dependence and the employment support offered in addiction-treatment programmes is ineffective.
John Marsden, Paul Anders, Helen Clark, Kyriacos Colocassis, Brian Eastwood, Jonathan Knight, Alexandra Melaugh, David Quinn, Virginia Wright, Jez Stannard   +9 more
doaj   +1 more source

Exploring the use of cannabis as a substitute for prescription drugs in a convenience sample

Harm Reduction Journal, 2021
Background The use of cannabis as medicine (CaM) both prescribed and non-prescribed has increased markedly in the last decade, mirrored in a global shift in cannabis policy towards a more permissive stance.
Sinikka L. Kvamme, Michael M. Pedersen, Kristine Rømer Thomsen, Birgitte Thylstrup   +3 more
doaj   +1 more source

COVID-19 and the drug situation in Lithuania

Journal of Geography, Politics and Society, 2022
The application of restrictive public health measures because of COVID-19 has affected all areas of life, including drug use, drug market, and the response of law enforcement and health, education, and social care institutions to the drug phenomenon.
Evelina Pridotkienė , Rūta Gedminienė , Rasa Povilanskienė , Brigita Rašimaitė , Viktorija Stifanovičiūtė   +4 more
doaj   +1 more source

Impulsive Lifestyle Counselling versus treatment as usual to reduce offending in people with co-occurring antisocial personality disorder and substance use disorder: a post hoc analysis

BMC Psychiatry, 2022
Objectives To assess the impact of a short psychoeducation intervention for antisocial personality disorder on offending after randomization to treatment. Design Multicentre, superiority, non-blinded randomized controlled trial.
Morten Hesse, Adriana del Palacio-Gonzalez, Birgitte Thylstrup   +2 more
doaj   +1 more source

4191 The Role of Suggestibility and Trait Anxiety in Young Adult Alcohol Use

Journal of Clinical and Translational Science, 2020
OBJECTIVES/GOALS: The purpose of this study was to investigate how suggestibility and social susceptibility relate to alcohol use in young adult non-dependent alcohol users, and the role of trait anxiety in this relationship. We hypothesized that greater
Alexandra Cowand, Melanie Schwandt, Alyssa Schneider, Jodi M. Gilman, Nancy Diazgranados, Vijay A. Ramchandani, Bethany L. Stangl   +6 more
doaj   +1 more source

cAMP Signaling in Pathobiology of Alcohol Associated Liver Disease

Biomolecules, 2020
The importance of cyclic adenosine monophosphate (cAMP) in cellular responses to extracellular signals is well established. Many years after discovery, our understanding of the intricacy of cAMP signaling has improved dramatically.
Mohamed Elnagdy, Shirish Barve, Craig McClain, Leila Gobejishvili   +3 more
doaj   +1 more source

Short- and long-term effects of ethanol administration in vivo on rat liver HMG-CoA reductase and cholesterol 7α-hydroxylase activities

Journal of Lipid Research, 1977
Short- and long-term effects of ethanol on HMG-CoA reductase (EC 1.1.1.34) and cholesterol 7α-hydroxylase activities in rat liver have been investigated.
M R Lakshmanan, R L Veech
doaj   +1 more source

Cholesterol as a modulator of cannabinoid receptor CB2 signaling

Scientific Reports, 2021
Signaling through integral membrane G protein-coupled receptors (GPCRs) is influenced by lipid composition of cell membranes. By using novel high affinity ligands of human cannabinoid receptor CB2, we demonstrate that cholesterol increases basal ...
Alexei Yeliseev, Malliga R. Iyer, Thomas T. Joseph, Nathan J. Coffey, Resat Cinar, Lioudmila Zoubak, George Kunos, Klaus Gawrisch   +7 more
doaj   +1 more source

Sex differences in nicotine-enhanced Pavlovian conditioned approach in rats

Biology of Sex Differences, 2019
Background Nicotine exposure enhances Pavlovian conditioned approach (PCA), or the learned approach to reward-predictive cues. While females show elevated approach to conditioned stimuli compared to males, potentially indicating heightened addiction ...
Sierra J. Stringfield, Aric C. Madayag, Charlotte A. Boettiger, Donita L. Robinson   +3 more
doaj   +1 more source