Results 301 to 310 of about 210,614 (338)
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An alcohol dehydrogenase ribozyme
Nature Structural & Molecular Biology, 2003We report an RNA molecule that exhibits activity analogous to that of alcohol dehydrogenase (ADH). Directed in vitro evolution was used to enrich nicotinamide adenine dinucleotide (NAD+)-dependent redox-active RNAs from a combinatorial pool. The most active ribozyme in the population forms a compact pseudoknotted structure and oxidizes an alcohol seven
Swetansu Pattnaik +2 more
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Alcohol and polyol dehydrogenases
Pharmacology Biochemistry and Behavior, 1983"Long" and "short" alcohol dehydrogenases with different structures and catalytic mechanisms exist and the same sub-grouping appears to apply to polyol dehydrogenases. Mammalian liver sorbitol dehydrogenase is clearly related to "long" alcohol dehydrogenases and has structural properties intermediate between those of mammalian and yeast alcohol ...
Mats Carlquist +5 more
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NOMENCLATURE OF ALCOHOL DEHYDROGENASES
Alcohol and Alcoholism, 1995Six different classes of mammalian alcohol dehydrogenase have been characterized. Most, if not all, are common to humans, mammals and many vertebrates, which therefore share class distinctions in general. Amino acid residue identities between classes are at the 60% level (70% in the case of one pair, class I/IV), whereas those for mammalian species ...
Jan-Olov Höög, Hans Jörnvall
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Science, 1968
Significant alcohol dehydrogenase activity has been demonstrated in the soluble fraction of rat brain and is very similar to the liver enzyme in kinetic properties and responses to inhibitors. A cerebral mechanism that oxidizes ethanol may play a significant role in local adjustments during exposure to ethanol and in the pathogenesis of the neural ...
Neil H. Raskin, Louis Sokoloff
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Significant alcohol dehydrogenase activity has been demonstrated in the soluble fraction of rat brain and is very similar to the liver enzyme in kinetic properties and responses to inhibitors. A cerebral mechanism that oxidizes ethanol may play a significant role in local adjustments during exposure to ethanol and in the pathogenesis of the neural ...
Neil H. Raskin, Louis Sokoloff
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2010
The family of mammalian alcohol dehydrogenases (ADHs) is widely expressed, and catalyzes the oxidation and reduction of many different alcohols and aldehydes. They have overlapping distributions in different tissues, as well as overlapping substrate specificities, and play a key role in metabolism of substrates such as ethanol, retinol, and ...
W.F. Bosron, H.J. Edenberg
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The family of mammalian alcohol dehydrogenases (ADHs) is widely expressed, and catalyzes the oxidation and reduction of many different alcohols and aldehydes. They have overlapping distributions in different tissues, as well as overlapping substrate specificities, and play a key role in metabolism of substrates such as ethanol, retinol, and ...
W.F. Bosron, H.J. Edenberg
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Alcohol and aldehyde dehydrogenase polymorphisms and alcoholism
Behavior Genetics, 1993The alcohol-flush reaction occurs in Asians who inherit the mutant ALDH2*2 allele that produces an inactive aldehyde dehydrogenase enzyme. In these individuals, high blood acetaldehyde levels are believed to be the cause of the unpleasant symptoms that follow drinking.
David W. Crabb +3 more
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Induction of Alcohol Dehydrogenase in the Rat
Nature, 1969ETHANOL is metabolized to acetaldehyde by a zinc containing enzyme, alcohol dehydrogenase (ADH)1–4. This is a rate limiting step and is dependent on the presence of nicotine adenine dinucleotide (NAD) which acts as a hydrogen acceptor5,6. Over 90 per cent of the alcohol ingested is oxidized and it is currently assumed that this occurs entirely in the ...
Angela Birchall, Steven P. Mistilis
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Chemico-Biological Interactions, 2017
Close to 80 years of research have brought MDR alcohol dehydrogenases (ADHs) from unknown molecular concepts to molecules known in exact detail regarding structural, functional and evolutionary properties. They can be traced backwards in at least six stages of development, to essentially the origin of cellular life, and have been monitored in a long ...
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Close to 80 years of research have brought MDR alcohol dehydrogenases (ADHs) from unknown molecular concepts to molecules known in exact detail regarding structural, functional and evolutionary properties. They can be traced backwards in at least six stages of development, to essentially the origin of cellular life, and have been monitored in a long ...
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The Alcohol Dehydrogenase System
1995Alcohol dehydrogenases of different types are common enzymes in nature. Two of these families, the medium-chain dehydrogenase/reductase family, MDR, and the shortchain dehydrogenase/reductase family, SDR, are well studied and known since long, but have experienced a recent “explosion” of new knowledge, extension and importance.
Olle Danielsson +4 more
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1980
Racial differences in alcohol sensitivity have been described by many authors (Wolff, 1973; Ewing et al., 1974). Variant forms of alcohol metabolizing enzymes have been proposed to play an important role in sensitivity to alcohol associated with facial flushing and other subjective symptoms (Stamatoyannopoulos et al., 1975; Goedde et al., 1979b; Harada
S. Harada +2 more
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Racial differences in alcohol sensitivity have been described by many authors (Wolff, 1973; Ewing et al., 1974). Variant forms of alcohol metabolizing enzymes have been proposed to play an important role in sensitivity to alcohol associated with facial flushing and other subjective symptoms (Stamatoyannopoulos et al., 1975; Goedde et al., 1979b; Harada
S. Harada +2 more
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