Results 31 to 40 of about 173,083 (258)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Czynniki ryzyka majaczenia alkoholowego u osób leczonych stacjonarnie w Polsce z powodu uzależnienia od alkoholu

Alcoholism and Drug Addiction, 2016
Introduction: Delirium tremens (DT) is a life-threatening complication that occurs in 5–33% of patients treated for alcohol withdrawal syndrome. The aim of the present study was to analyse the risk factors for delirium tremens among patients treated for ...
Aneta Michalska, Maciej Kopera, Bartłomiej Gmaj, Agata Łoczewska, Natalia Szejko, Dorota Wołyńczyk-Gmaj, Eliza Kisielińska, Sylwia Fudalej, Marcin Wojnar   +8 more
doaj   +1 more source

Neurofilament Light Chain Is a Promising Biomarker in Alcohol Dependence

Frontiers in Psychiatry, 2021
Background: Alcohol dependence, a global public health problem, leads to structural and functional damage in the brain. Alcohol dependence patients present complex and varied clinical manifestations and live with general complaints existing in ...
Yanfei Li, Ranran Duan, Zhe Gong, Lijun Jing, Tian Zhang, Yong Zhang, Yanjie Jia   +6 more
doaj   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Cognitive functions in alcohol use and cannabis use disorder: A cross-sectional study

Journal of Mental Health and Human Behaviour, 2019
Background and Aim: Alcohol and cannabis misuse have an impact on neurocognition. This cross-sectional study evaluated the neuropsychological performance of individuals with alcohol dependence and cannabis dependence with concomitant alcohol use ...
Ottilingam Somasundaram Ravindran, G Nandini, Natarajan Shanmugasundaram, V Vivian Kapil   +3 more
doaj   +1 more source

Sex differences in the neuroanatomy of alcohol dependence: hippocampus and amygdala subregions in a sample of 966 people from the ENIGMA Addiction Working Group

Translational Psychiatry, 2021
Males and females with alcohol dependence have distinct mental health and cognitive problems. Animal models of addiction postulate that the underlying neurobiological mechanisms are partially distinct, but there is little evidence of sex differences in ...
Sally Grace, Maria Gloria Rossetti, Nicholas Allen, Albert Batalla, Marcella Bellani, Paolo Brambilla, Yann Chye, Janna Cousijn, Anna E Goudriaan, Robert Hester, Kent Hutchison, Izelle Labuschagne, Reza Momenan, Rocio Martin-Santos, Peter Rendell, Nadia Solowij, Rajita Sinha, Chiang-shan Ray Li, Lianne Schmaal, Zsuzsika Sjoerds, Chao Suo, Gill Terrett, Ruth J. van Holst, Dick J. Veltman, Murat Yücel, Paul Thompson, Patricia Conrod, Scott Mackey, Hugh Garavan, Valentina Lorenzetti   +29 more
doaj   +1 more source

Caregiver burden in alcohol dependence syndrome and its sociodemographic correlates: A cross-sectional study from South India

Kerala Journal of Psychiatry, 2023
Background: Caring for people with severe mental and medical illness adversely affects their natural caregivers, which is measured as caregiver burden (CGB).
Jithin T Joseph, V R Aniji , V Arun, Mathew J Valamparampil   +3 more
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

A Prospective Comparison of Bipolar I and II Subjects With and Without Comorbid Alcohol Dependence From the COGA Dataset

Frontiers in Psychiatry, 2020
Objective: Comorbidity of alcohol use disorders in bipolar subjects is high as indicated by epidemiological and clinical studies. Though a more severe course of bipolar disorder in subjects with comorbid alcohol dependence has been reported, fewer ...
Ulrich W. Preuss, Ulrich W. Preuss, M. N. Hesselbrock, V. M. Hesselbrock   +3 more
doaj   +1 more source

Men with and without alcohol dependence: A comparative study of Triguna, nonattachment, personality and subjective well-being

International Journal of Yoga, 2022
Context: Indian models of personality are seldom explored in relation to alcohol dependence. Triguna is an Indian model of personality originating from the Sankhya philosophy, whereby three gunas, Sattva, Rajas and Tamas describe personality features ...
Chandana Nedungottil, Jyotsna Agrawal, Mahendra Prakash Sharma, Pratima Murthy   +3 more
doaj   +1 more source