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Objective: (1) To perform a 9‐year study of abstinence, lapse, and relapse in 180 chronic alcoholic patients, participants of the Outpatient Longterm Intensive Therapy for Alcoholics (OLITA); (2) To investigate the role of supervised alcohol deterrents (AD) in relapse prevention and as an adjunct for maintenance of long‐term abstinence.Method: This ...
Henning Krampe+2 more
exaly +6 more sources
Pictorial warning labels as deterrents of alcohol abuse [PDF]
PurposeThe purpose of this research is to demonstrate the effectiveness of pictorial warning labels that leverage the risk of obesity as a deterrent against alcohol abuse. It evaluates the impact of three different kinds of warning labels that can potentially discourage alcoholic drinking: (1) a claim, in text format, that cautions consumers about the ...
Luigi Piper+3 more
semanticscholar +6 more sources
3D printed opioid medicines with alcohol-resistant and abuse-deterrent properties [PDF]
In the past decade, prescriptions for opioid medicines have been exponentially increasing, instigating opioid abuse as a global health crisis associated with high morbidity and mortality. In particular, diversion from the intended mode of opioid administration, such as injecting and snorting the opioid, is a major problem that contributes to this ...
Jun Jie Ong+6 more
openalex +4 more sources
Investigating Whether Bereavement by Suicide and Other Unnatural Causes Has a Deterrent Effect on Alcohol or Drug Use in Young Adults [PDF]
Bereavement by suicide and other unnatural causes is associated with suicide but evidence regarding risk of substance misuse is inconsistent. This may be due to heterogeneity in patterns of alcohol or drug use after traumatic bereavement; some increasing use to cope with the loss and others reducing use.
Alexandra Pitman+2 more
openalex +4 more sources
Sodium oxybate (SMO) has been approved in Italy and Austria for the maintenance of abstinence in alcohol dependent (AD) patients. Although SMO is well tolerated in AD patients, cases of abuse and misuse have been reported outside the therapeutic setting.
Julien Guiraud+16 more
openalex +6 more sources
Glioblastoma (GB) is the most common primary brain tumor in adults. It is also one of the most lethal and devastating malignancy with a median patient survival of 14 months despite surgical resection and radiochemotherapy. Recent data has suggested that radiotherapy may trigger treatment resistance by promoting the diffuse invasive phenotype of GB ...
Sebastien Stroh
openalex +3 more sources
(425) Dissolution studies in the presence of alcohol with an abuse-deterrent, extended-release morphine product candidate [PDF]
Torben Elhauge+3 more
openalex +3 more sources
Assessment of Alcohol-Induced Dose Dumping with a Hydrocodone Bitartrate Extended-Release Tablet Formulated with CIMA® Abuse Deterrence Technology [PDF]
Greater drug content requirements for extended-release (ER) opioids necessitate greater protection against dose dumping. Hydrocodone ER employs the CIMA(®) Abuse-Deterrence Technology platform, which provides resistance against rapid release of the active moiety when the tablet is manipulated or taken with alcohol.Assess effects of alcohol on ...
Mona Darwish+4 more
openaire +3 more sources
The threat of application of legal sanctions remains the prominent approach to reduce the prevalence of drink driving in a vast array of motoring jurisdictions. However, ongoing questions remain regarding: (a) the extent that such mechanisms impact upon offending behaviours, (b) the deleterious effect alcohol consumption has on decisions to drink and ...
Freeman, J+5 more
openaire +4 more sources
Since the abolition of the death penalty in 1995, the Supreme Court has sentenced several offenders to lengthy prison terms ranging from 10 to penal servitude for life – both in cases where penal servitude for life is a discretionary sentence and where it is a mandatory sentence. The aim of this article is to look at all cases between 1995 (when the
Matthew Lamport+4 more
openaire +38 more sources