Results 61 to 70 of about 943,763 (288)

Probing host pathogen cross-talk by transcriptional profiling of both Mycobacterium tuberculosis and infected human dendritic cells and macrophages [PDF]

, 2008
This study provides the proof of principle that probing the host and the microbe transcriptomes simultaneously is a valuable means to accessing unique information on host pathogen interactions.
A Kolb-Maurer, A Kumar, A Savina, A Yamauchi, A Yoshimura, Alessandra Mortellaro, AM Talaat, AM Talaat, Antoine Tanne, B Hutter, B Pron, BM Bolstad, Brigitte Gicquel, C Nathan, CH Wang, D Chaussabel, D Lombardi, D Schnappinger, D Schnappinger, D Werling, Derya Unutmaz, DG Russell, DJ Beste, DM Roberts, E Giacomini, E Werner, F Niedergang, FS Machado, G Cappelli, G Harth, G Sulzenbacher, GJ Nau, GK Smyth, GK Smyth, GR Stewart, H Ohno, H Rachman, HD Park, I Vergne, J Bacon, JA Mangan, JC Betts, JC Boldrick, JD McKinney, JP Wang, L Shi, L Tailleux, LP Barker, LR Camacho, Ludovic Tailleux, M Kanehisa, M Kanehisa, M Pelizzola, MA Harris, Maria Foti, Mattia Pelizzola, MB Eisen, MI Voskuil, Michael Withers, MM Westcott, MV Tullius, N Mohagheghpour, Neil G. Stoker, Olivier Neyrolles, P Ricciardi-Castagnoli, Paola Ricciardi Castagnoli, PC Karakousis, Philip D. Butcher, R Van der Geize, RA Henderson, RA Irizarry, S Ehrt, S Nicholson, S Ragno, S Stenger, S Sturgill-Koszycki, Simon J. Waddell, SJ Waddell, SJ Waddell, SL Kendall, SL Kendall, ST Cole, T Kawai, T Parish, X Jiao, Y Hu, Y Yuan   +86 more
core   +6 more sources

Dysfunctional TRIM31 of POMC Neurons Provokes Hypothalamic Injury and Peripheral Metabolic Disorder under Long‐Term Fine Particulate Matter Exposure

Advanced Science, EarlyView.
Particulate matter ≤2.5 µm (PM2.5) elevates risks of neurological and chronic metabolic diseases, but the underlying mechanisms linking PM2.5‐induced central nervous system (CNS) injury to metabolic dysfunction remain unclear. Hypothalamic pro‐opiomelanocortin‐expressing (POMC+) neurons regulate systemic metabolic homeostasis, and tripartite motif ...
Chenxu Ge, Jiamao Lin, Changsheng Yang, Chuanwang Miao, Fengxiang Li, Shuqiang Zhao, Lei Zou, Xuedong Teng, Lina Liu, Tingguang Li, Yan Sun, Qiang Li, Deshuai Lou, Linfeng Hu, Xi Liu, Gang Kuang, Jing Luo, Minxuan Xu, Minghui Chang, Jun Tan, Yanrong Ren, Bochu Wang   +21 more
wiley   +1 more source

Protein Language Model‐Guided Engineering of a 2,3‐Butanediol Dehydrogenase for the Enantioselective Synthesis of Cyclic α‐Hydroxy Ketones

Advanced Science, EarlyView.
A (2R,3R)‐butanediol dehydrogenase from Bacillus subtilis (BsBDH) is engineered for the enantioselective synthesis of 2‐hydroxycyclohexanone. A PASS computational design strategy is proposed to enhance the thermostability of BsBDH. Moreover, ESM‐1v combined with ISM is utilized for enhancing and inverting its stereoselectivity.
Haote Ding, Ling Jiang, Yijia Song, Zhongji Pu, Lirong Yang, Haoran Yu   +5 more
wiley   +1 more source

Polyphosphazenes as Tunable and Recyclable Supports To Immobilize Alcohol Dehydrogenases and Lipases: Synthesis, Catalytic Activity, and Recycling Efficiency [PDF]

, 2010
Financial support from the Spanish Ministerio de Ciencia e Innovación (MICINN, Project CTQ2007-61126 and CTQ 2007-61188) is gratefully ...
Carriedo Ule, Gabino Alejandro, Cuetos Fernández, Aníbal, Gotor Santamaría, Vicente Miguel, Lavandera García, Iván, Valenzuela Valdés, María Luisa   +4 more
core   +2 more sources

Nanozymes Integrated Biochips Toward Smart Detection System

Advanced Science, EarlyView.
This review systematically outlines the integration of nanozymes, biochips, and artificial intelligence (AI) for intelligent biosensing. It details how their convergence enhances signal amplification, enables portable detection, and improves data interpretation.
Dongyu Chen, Wang Zheng, Zhihui Zhang, Shenping Yu, Xinxin Hang, Han Wu, Xiao‐Wei Xiang, Wei Mu, Yanli Jiao, Zaizai Dong, Lingqian Chang   +10 more
wiley   +1 more source

Detoxification and stress response genes expressed in a western North American bumble bee, Bombus huntii (Hymenoptera: Apidae) [PDF]

, 2013
BACKGROUND: The Hunt bumble bee (Bombus huntii Greene, Hymenoptera: Apidae) is a holometabolous, social insect important as a pollinator in natural and agricultural ecosystems in western North America.
Dennis L Welker, James P Strange, Junhuan Xu, Rosalind R James   +3 more
core   +1 more source

Synthesis of pyruvate: ferredoxin oxidoreductase and alcohol dehydrogenase E enzymes during Giardia intestinalis excystation.

Biomedica : revista del Instituto Nacional de Salud, 2010
Giardia intestinalis is a unicellular parasite of worldwide distribution. It causes an intestinal illness known as giardiasis, and it is probably the earliest diverging eukaryotic microorganism. Previously, changes have been reported in the expression of mRNAs at several stages of the life cycle; however specific enzymatic activity changes have not ...
Niño, Carlos Alberto, Wasserman, Moisés   +1 more
openaire   +3 more sources

Ce‐Doped Lignin‐Based Nanozyme with Heat‐Activated Hydrolase Activity

Advanced Science, EarlyView.
A novel Ce‐doped lignin‐based hydrolase nanozyme (Ce‐AL) is synthesized using Ce ions coordinated with aminated industrial lignin. The Ce‐AL effectively hydrolyzes phosphate ester bonds and protein amide bonds, maintain high activity at 100°C, and successfully fights bacteria biofilms.
Xin Liu, Lijun Li, Xue Zhang, Alireza Ashori, Fubao Sun, Feng Xu, Xueming Zhang, Yao Chen   +7 more
wiley   +1 more source

Structural insights into alcohol dehydrogenases catalyzing asymmetric reductions

Critical Reviews in Biotechnology, 2019
Alcohol dehydrogenases are a group of oxidoreductases that specifically use NAD(P)+ or NAD(P)H as cofactors for electron acceptance or donation and catalyze interconversion between alcohols and corresponding carbonyl compounds.
Jianhong An, Y. Nie, Yan Xu
semanticscholar   +1 more source

Nanozymes for Energy and Environmental Sustainability

Advanced Science, EarlyView.
At present, the widely used nanozymes are oxidoreductase and hydrolase, which have proved to have great application prospects in energy and environment. ABSTRACT Nanozymes have shown remarkable promise in addressing pressing challenges in energy and environmental sustainability.
Xiaoqi Li, Jinxing Chen, Shaojun Dong
wiley   +1 more source