Results 61 to 70 of about 586,881 (303)

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
wiley   +1 more source

Parental alcohol use disorders and alcohol use and disorders in offspring: a community study

Psychological Medicine, 2002
Background. We examined the association between parental alcohol use disorders and patterns of alcohol consumption and DSM-IV alcohol use disorders in their offspring in a community-based sample of young adults.Methods. Data are based on baseline and 4-year follow-up data of 2427 respondents aged 14–24 at baseline.
Lieb, R., Merikangas, K. R., Höfler, M., Pfister, H., Isensee, B., Wittchen, H.-U.   +5 more
openaire   +5 more sources

Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78‐ATF6‐CHOP signaling pathway

FEBS Open Bio, EarlyView.
Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei, Zhanbiao Liu, Jingjing Shi, Qian Jin, Wenqian Chen, Xuejun Chen, Liqin Li, Hui Chen   +7 more
wiley   +1 more source

Borderline personality disorder and substance use disorders: an updated review

Borderline Personality Disorder and Emotion Dysregulation, 2018
For decades, clinicians and researchers have recognized that borderline personality disorder (BPD) and substance use disorders (SUDs) are often diagnosed within the same person (e.g., (Gunderson JG.
Timothy J. Trull, Lindsey K. Freeman, Tayler J. Vebares, Alexandria M. Choate, Ashley C. Helle, Andrea M. Wycoff   +5 more
doaj   +1 more source

Alcohol Use Disorder

, 2012
Millions of individuals use alcohol every day; however, not everyone experiences a problem due to such use. It is therefore helpful to conceptualize alcohol use as ranging on a continuum from nonproblematic social use (e.g., a glass of wine with dinner); to alcohol misuse (e.g., a one-time incident of binge drinking); to excessive use or abuse (e.g ...
Stanley (Shlomo) Einstein, Shulamith Lala Ashenberg Straussner, Sarina Beth Straussner   +2 more
openaire   +2 more sources

The impact of frailty syndrome on skeletal muscle histology: preventive effects of exercise

FEBS Open Bio, EarlyView.
Frailty syndrome exacerbates skeletal muscle degeneration via increased ECM deposition and myofiber loss. This study, using a murine model, demonstrates that endurance exercise attenuates these histopathological alterations, preserving muscle integrity. Findings support exercise as a viable strategy to counteract frailty‐induced musculoskeletal decline
Fujue Ji, Hae Sung Lee, Haesung Lee, Jong‐Hee Kim   +3 more
wiley   +1 more source

Intravenous ketamine for severe alcohol use disorder at Moi Teaching & Referral Hospital, Kenya: a case report

Substance Abuse Treatment, Prevention, and Policy, 2023
Background Alcohol use disorder is prevalent globally and in Kenya, and is associated with significant health and socio-economic consequences. Despite this, available pharmacological treatment options are limited.
Florence Jaguga, Philip Kirwa, Benson Gakinya, Imran Manji, Thomas Andale, Daniel Kinyanjui, Edith Kamaru Kwobah, Felicita Mwangi, Kituyi Werunga, Josephat Kerema, Charles Kwobah, Eunice Temet, Julia Songok, Wilson K. Aruasa   +13 more
doaj   +1 more source

Former heroin-dependent alcohol use disorder patients. prevalence, addiction history and clinical features [PDF]

, 2015
Aims: To examine the prevalence of former heroin dependence (FHA) in Alcohol Use Disorder (AUD) patients; to compare the clinical characteristics of FHA-AUD patients versus AUD patients without any past use of heroin at alcohol treatment entry; to ...
Ceccanti, Mauro, Maremmani, Angelo Giovanni Icro, Maremmani, Icro, Pacini, Matteo   +3 more
core   +1 more source

FGF14 GAA Intronic Expansion in Unsolved Adult‐Onset Ataxia in the Care4Rare Canada Consortium

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Spinocerebellar ataxias (SCA) represent a clinically and genetically heterogeneous group of progressive neurodegenerative diseases with prominent cerebellar atrophy. Recently, a novel pathogenic repeat expansion in intron 1 of FGF14 was identified, causing adult‐onset SCA (SCA27B). We aimed to determine the proportion
Alexanne Cuillerier, Giulia F. Del Gobbo, Layla Mackay, Erika Wall, Madeline Couse, Laura M. McDonell, Mireille Cloutier, Matt C. Danzi, Jodi Warman‐Chardon, Pierre R. Bourque, Oksana Suchowersky, Alan Mears, Luke Seldenthuis, Wendy Mears, Laura Larrigan, Alexandre White‐Brown, Gerald Pfeffer, Dennis E. Bulman, David Dyment, Care4Rare Canada Consortium, Kym M. Boycott   +20 more
wiley   +1 more source

Substance Use Disorder Is Associated With Alcohol-Associated Liver Disease in Patients With Alcohol Use Disorder

Gastro Hep Advances, 2022
Background and Aims: Substance use disorder (SUD) commonly associates with alcohol use disorder (AUD), and certain substances have independently been shown to drive liver injury. In this work, we sought to determine if coexisting SUD in patients with AUD
Augustin G.L. Vannier, Vladislav Fomin, Raymond T. Chung, Suraj J. Patel, Esperance Schaefer, Russell P. Goodman, Jay Luther   +6 more
doaj