Results 171 to 180 of about 122,587 (295)

RNA‐Based Therapies for Inherited Metabolic Disorders

open access: yesJournal of Inherited Metabolic Disease, Volume 49, Issue 2, March 2026.
ABSTRACT Inherited metabolic disorders (IMDs) are a diverse and complex group of genetic conditions resulting from deficiencies in enzymes, transporters, or cofactors. These deficiencies lead to metabolic dysfunction and severe clinical consequences. Despite significant progress in understanding their molecular basis, treatment options remain limited ...
Reddy Sreekanth Vootukuri   +5 more
wiley   +1 more source

Pharmacologic Treatment of Kleine–Levin Syndrome: A Case Report and Comprehensive Review of Therapeutic Options

open access: yesNeuropsychopharmacology Reports, Volume 46, Issue 1, March 2026.
A 12‐year‐old girl with Klein‐Levin syndrome showed central hypopneas and REM sleep without atonia on 24‐h polysomnography, which normalized after clarithromycin treatment alongside clinical remission. ABSTRACT Kleine–Levin syndrome (KLS) is a rare disorder with limited literature on treatment options and efficacy, especially in adolescents.
Sarisa Thawongit   +2 more
wiley   +1 more source

Impact of a substance use screening program on racial disparities in urine toxicology testing

open access: yesPregnancy, Volume 2, Issue 2, March 2026.
Abstract Objective To evaluate whether implementing a standardized substance use screening program reduced racial disparities in urine toxicology (Utox) testing among delivery admissions. Methods We conducted a retrospective cohort study of delivery admissions at a single academic center from June 2019 to June 2025. To address known disparities in Utox
Mariam Naqvi   +7 more
wiley   +1 more source

Queer in Science, Technology, Engineering, and Mathematics: Following the Intersections of Queerness, Transness and Science Identities

open access: yesScience Education, Volume 110, Issue 2, Page 673-692, March 2026.
ABSTRACT This multiple case study explores the intersections of queerness/transness and science education through a combined framework of queer theory, intersectionality, the construct of figured worlds and science identity. The study uses a life‐history approach to characterize the trajectories of three purposefully selected queer individuals who are ...
Nelly K. M. Marosi   +3 more
wiley   +1 more source

Alcohol withdrawal syndrome in trauma patients: a study using the Trauma Quality Program Participant User File. [PDF]

open access: yesTrauma Surg Acute Care Open, 2023
Jones TJ   +6 more
europepmc   +1 more source

Efficacy of combined varenicline and nicotine replacement therapy compared with varenicline or nicotine replacement therapy alone for smoking cessation: A systematic review and meta‐analysis

open access: yesAddiction, Volume 121, Issue 3, Page 499-509, March 2026.
Abstract Aims To assess whether combining nicotine replacement therapy (NRT) with varenicline improves long‐term smoking cessation rates compared with varenicline or NRT alone. Method Systematic review and meta‐analysis of randomized controlled trials (RCTs) or quasi‐RCTs, conducted according to PRISMA guidelines.
Xinmei Zhou   +18 more
wiley   +1 more source

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