RNA‐Based Therapies for Inherited Metabolic Disorders
ABSTRACT Inherited metabolic disorders (IMDs) are a diverse and complex group of genetic conditions resulting from deficiencies in enzymes, transporters, or cofactors. These deficiencies lead to metabolic dysfunction and severe clinical consequences. Despite significant progress in understanding their molecular basis, treatment options remain limited ...
Reddy Sreekanth Vootukuri +5 more
wiley +1 more source
Phenobarbital for Severe Alcohol Withdrawal Syndrome: A Multicenter Retrospective Cohort Study. [PDF]
Bosch NA, Law AC, Walkey AJ.
europepmc +1 more source
A 12‐year‐old girl with Klein‐Levin syndrome showed central hypopneas and REM sleep without atonia on 24‐h polysomnography, which normalized after clarithromycin treatment alongside clinical remission. ABSTRACT Kleine–Levin syndrome (KLS) is a rare disorder with limited literature on treatment options and efficacy, especially in adolescents.
Sarisa Thawongit +2 more
wiley +1 more source
Valproate-Enhanced Protocols for Alcohol Withdrawal Syndrome: A Brief Review and Retrospective Study of Efficacy and the Ability to Reduce Benzodiazepine Use. [PDF]
Pardossi S +5 more
europepmc +1 more source
Alcohol Withdrawal Syndrome as a Precipitating Factor of Takotsubo Cardiomyopathy on a Background of Wernicke's Encephalopathy. [PDF]
Costa IN +4 more
europepmc +1 more source
Impact of a substance use screening program on racial disparities in urine toxicology testing
Abstract Objective To evaluate whether implementing a standardized substance use screening program reduced racial disparities in urine toxicology (Utox) testing among delivery admissions. Methods We conducted a retrospective cohort study of delivery admissions at a single academic center from June 2019 to June 2025. To address known disparities in Utox
Mariam Naqvi +7 more
wiley +1 more source
ABSTRACT This multiple case study explores the intersections of queerness/transness and science education through a combined framework of queer theory, intersectionality, the construct of figured worlds and science identity. The study uses a life‐history approach to characterize the trajectories of three purposefully selected queer individuals who are ...
Nelly K. M. Marosi +3 more
wiley +1 more source
Alcohol withdrawal syndrome in trauma patients: a study using the Trauma Quality Program Participant User File. [PDF]
Jones TJ +6 more
europepmc +1 more source
Abstract Aims To assess whether combining nicotine replacement therapy (NRT) with varenicline improves long‐term smoking cessation rates compared with varenicline or NRT alone. Method Systematic review and meta‐analysis of randomized controlled trials (RCTs) or quasi‐RCTs, conducted according to PRISMA guidelines.
Xinmei Zhou +18 more
wiley +1 more source
Guideline concordance of electronic health record order sets for hospital-based treatment of alcohol withdrawal syndrome. [PDF]
Cohen SM +5 more
europepmc +1 more source

