Results 151 to 160 of about 387,299 (303)

Machine learning model for non-alcoholic steatohepatitis diagnosis based on ultrasound radiomics

BMC Medical Imaging
Background Non-Alcoholic Steatohepatitis (NASH) is a crucial stage in the progression of Non-Alcoholic Fatty Liver Disease(NAFLD). The purpose of this study is to explore the clinical value of ultrasound features and radiological analysis in predicting ...
Fei Xia, Wei Wei, Junli Wang, Yayang Duan, Kun Wang, Chaoxue Zhang   +5 more
doaj   +1 more source

CD44 is a key player in non-alcoholic steatohepatitis

, 2017
International audienceCluster of differentiation (CD)44 regulates adipose tissue inflammation in obesity and hepatic leukocyte recruitment in a lithogenic context.
Patouraux, Stéphanie, Béatrice Bailly-Maitre, Cynthia Lebeaupin, Carmelo Luci, Bailly-Maitre, Béatrice, Clémence M. Canivet, Iannelli, Antonio, Philippe Gual, Stéphanie Bonnafous, Gual, Philippe, Saint-Paul, Marie-Christine, Adeline Bertola, Anne-Sophie Schneck, Gugenheim, Jean, Albert Tran, Bonnafous, Stéphanie, Canivet, Clémence, Jean Gugenheim, Anty, Rodolphe, Marie-Christine Saint-Paul, Bertola, Adeline, Déborah Rousseau, Rousseau, Déborah, Tran, Albert, Lebeaupin, Cynthia, Schneck, Anne-Sophie, Rodolphe Anty, Luci, Carmelo, Antonio Iannelli, Stéphanie Patouraux   +29 more
core   +1 more source

Metabolic Dysfunction‐Associated Steatotic Liver Disease and Obesity: Pathogenesis, Diagnostics, Risk Stratification, and Therapeutic Approach

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) has emerged as the most prevalent chronic liver disease worldwide, closely linked to the global rising incidence of obesity and metabolic syndrome. This review synthesizes current evidence on the pathogenesis, gut–liver axis, and multidisciplinary management of MASLD within the ...
Beom Kyung Kim
wiley   +1 more source

The PPARα Agonist Fenofibrate Prevents Formation of Protein Aggregates (Mallory-Denk bodies) in a Murine Model of Steatohepatitis-like Hepatotoxicity

Scientific Reports, 2018
Chronic intoxication of mice with the porphyrinogenic compound 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) leads to morphological and metabolic changes closely resembling steatohepatitis, a severe form of metabolic liver disease in humans.
Aniket Nikam, Jay V. Patankar, Meghana Somlapura, Pooja Lahiri, Vinay Sachdev, Dagmar Kratky, Helmut Denk, Kurt Zatloukal, Peter M. Abuja   +8 more
doaj   +1 more source

Metformin in the treatment of patients with non-alcoholic steatohepatitis

, 2004
Background: Increased insulin resistance is the major pathogenic mechanism in the development of non-alcoholic ...
Z. Yesilova, K. Dagalp, A. Tuzun, M. Gulsen, A. Uygun, S. Deveci, Deveci, S, Uygun, A, Dagalp, K, Tuzun, A, A. T. Isik, IŞIK, AHMET TURAN, A. Kadayifci, T. Ozgurtas, Ozgurtas, T, Kadayifci, A, Yesilova, Z, Gulsen, M   +17 more
core   +1 more source

Estimated Body Fat Percentage and Triglyceride‐Glucose Index for Identifying MASLD in Lean Asian Adults: A Cross‐Sectional Analysis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) is increasingly prevalent among lean Asian populations, yet effective strategies for identifying high‐risk individuals remain limited. We investigated the associations of body fat percentage (BF%) and the triglyceride‐glucose (TyG) index with lean MASLD and evaluated their ...
Xiang‐Ran Kong, Ya‐Li Chen, Rui Li, Lu‐Xiang Shang, Sha Sha   +4 more
wiley   +1 more source

Plasma retinol levels in liver donors and patients with simple steatosis and non-alcoholic steatohepatitis.

, 2018
LD: liver donors, SS: simple steatosis, NASH: non-alcoholic steatohepatitis, NAFLD: non-alcoholic fatty liver disease (SS: simple steatosis + NASH: non-alcoholic steatohepatitis).
Elena M. Comelli (2802319), Ian McGilvray (5916812), Anastasia Teterina (5916809), Paulina Pettinelli (5916806), Scott K. Fung (5916815), Bianca M. Arendt (2802313), Sandra E. Fischer (2802325), Johane P. Allard (2802316)   +7 more
core   +1 more source

Interactive Roles of Metabolic Dysfunction‐Associated Steatotic Liver Disease and Nutritional Status in the Prognosis of Patients With Hepatocellular Carcinoma After Surgical Resection

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT The prognostic effect of concurrent metabolic dysfunction‐associated steatotic liver disease (MASLD) on outcomes for hepatocellular carcinoma (HCC) patients remains unclear. The Prognostic Nutritional Index (PNI) reflects nutritional and inflammatory status and is a well‐known prognostic factor.
Chun‐Ting Ho, Chien‐An Liu, Chia‐Jung Ho, Yi‐Chen Lin, Shin‐Yu Tsai, Hao‐Jan Lei, Shu‐Cheng Chou, Yi‐Hsiang Huang, Ming‐Chih Hou, Jaw‐Ching Wu, Chien‐Wei Su   +10 more
wiley   +1 more source

Biomarkers for staging fibrosis and non-alcoholic steatohepatitis in non-alcoholic fatty liver disease (the LITMUS project) : a comparative diagnostic accuracy study

, 2023
: Background The reference standard for detecting non-alcoholic steatohepatitis (NASH) and staging fibrosis-liver biopsy-is invasive and resource intensive.
Vali, Yasaman, Yunis, Carla, Holleboom, Adriaan G., Ekstedt, Mattias, Cortez-Pinto, Helena, Zafarmand, Mohammad Hadi, Bossuyt, Patrick M., Ostroff, Rachel, Lee, Jenny, Allison, Mike, Geier, Andreas, Torstenson, Richard, Schattenberg, Joern M., Francque, Sven, Brass, Clifford, Pais, Raluca, Pavlides, Michael, Bedossa, Pierre, Duffin, Kevin, Ratziu, Vlad, Yki-Jarvinen, Hannele, Anstee, Quentin M., Petta, Salvatore, Wonders, Kristy, Karsdal, Morten, Chen, Yu, Cobbold, Jeremy F., Leeming, Diana Julie, Aithal, Guruprasad P., Crespo, Javier, Bugianesi, Elisabetta, Tiniakos, Dina, Boursier, Jerome, Romero-Gomez, Manuel, Dufour, Jean-Francois, Harrison, Stephen A., Papatheodoridis, Georgios   +36 more
core  

Cardiometabolic Biomarkers for Disease Severity Prediction in Metabolic Dysfunction‐Associated Steatotic Liver Disease

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT The impacts of cardiometabolic risk factors (CMRFs) and the biomarkers on disease severity in metabolic dysfunction‐associated steatotic liver disease (MASLD) remain elusive. Accordingly, a multicenter study by recruiting MASLD patients from a nationwide registry database was conducted with a total of 2882 MASLD patients (54.1% males, mean age 
Jee‐Fu Huang, Chi‐Yi Chen, Ming‐Jong Bair, Tzu‐Chun Lin, Ming‐Lun Yeh, Pei‐Chien Tsai, Yu‐Ju Wei, Chih‐Wen Wang, Po‐Chen Liang, Ming‐Yen Hsieh, Mei‐Hsuan Lee, Chia‐Yen Dai, Chung‐Feng Huang, Ming‐Lung Yu, Wan‐Long Chuang   +14 more
wiley   +1 more source