Results 161 to 170 of about 387,299 (303)

Hypoxia aggravates non-alcoholic steatohepatitis in mice lacking hepatocellular PTEN

, 2010
The metabolic disorders that predispose patients to NASH (non-alcoholic steatohepatitis) include insulin resistance and obesity. Repeated hypoxic events, such as occur in obstructive sleep apnoea syndrome, have been designated as a risk factor in the ...
Stroka, Deborah, Piguet, Anne-Christine, Dufour, Jean-François, Zimmermann, Arthur   +3 more
core   +1 more source

Thyroid-stimulating hormone variation within the euthyroid range and the severity of fatty liver disease in patients with type 2 diabetes mellitus: A cross-sectional study

Journal of the Pakistan Medical Association
Objective: To identify the relationship between thyroid-stimulating hormone levels within the euthyroid range and the severity of fatty liver disease in patients with type 2 diabetes mellitus.
Sunnia Khan, Asim Zulfiqar, Kiran Fatima, Samia Kausar, Muhammad Farooq, Qurrat ul Ain Kalim   +5 more
doaj   +1 more source

Systematic review: the epidemiology and natural history of non‐alcoholic fatty liver disease and non‐alcoholic steatohepatitis in adults

Alimentary Pharmacology and Therapeutics, 2011
G. Vernon, A. Baranova, Z. Younossi
semanticscholar   +1 more source

Role of MicroRNA in Chronic Alcoholic and Non-alcoholic Liver Disease and Pathology

International Journal of Bio-Resource and Stress Management, 2014
MicroRNAs (miRNA) are highly conserve non-coding RNAs which regulate gene expression, different aspect of cell signaling, cellular activity, cell differentiation and development, metabolism, proliferation, programmed cell death, viral and bacterial ...
Biswanath Patra, Vikram Arya
doaj  

Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial.

The Lancet, 2019
Z. Younossi, V. Ratziu, R. Loomba, M. Rinella, Q. Anstee, Z. Goodman, P. Bedossa, A. Geier, S. Beckebaum, P. Newsome, D. Sheridan, M. Sheikh, J. Trotter, W. Knapple, E. Lawitz, M. Abdelmalek, K. Kowdley, A. Montaño-Loza, J. Boursier, P. Mathurin, E. Bugianesi, G. Mazzella, A. Olveira, H. Cortez‐Pinto, I. Graupera, D. Orr, L. Gluud, J. Dufour, D. Shapiro, J. Campagna, L. Zaru, L. Macconell, R. Shringarpure, S. Harrison, A. Sanyal   +34 more
semanticscholar   +1 more source

Toxicity Differences Between Microplastics and Nanoplastics in Organs: From Molecular Mechanisms to Potential Therapeutic Strategies

Med Research, EarlyView.
This review systematically compares the size‐dependent toxicity of microplastics and nanoplastics in the intestine, liver, kidney, lung, and brain. Particle size determines bioavailability, barrier penetration, and injury mechanisms. Because of their small size and high surface reactivity, NPs readily cross the intestinal epithelium and blood–brain ...
Yixian Cheng, Junjie Chen, Rui Fu, Jiawei Zhang, Jianguang Jia, Wei Wang, Zheng Zhang, Peng Zhang, Haosong Chen, Huake Cao, Gang Li, Weiwei Sheng, Ting Li, Bo Chen, Guodong Cao   +14 more
wiley   +1 more source

Pathophysiological Similarities and Synergisms in Alcoholic and Non-Alcoholic Steatohepatitis

, 2010
Chronic alcohol consumption is one of the main etiological factors for liver disease worldwide, however only a fraction of drinkers develop significant hepatic inflammation (alcoholic steatohepatitis), and even less progress to significant hepatic ...
Claus Hellerbrand, Hellerbrand, Claus
core   +1 more source

DUCK‐Net: automated deep learning segmentation of ductular reactions in murine liver injury captures multicellular niche dynamics from H&E morphology

The Journal of Pathology, EarlyView.
Abstract Ductular reactions (DRs) are dynamic and complex multicellular responses that occur as a result of various hepatic injuries. Precise identification and quantification of the extent of DRs is a cornerstone of pre‐clinical modelling of liver disease, with links to inflammation, fibrosis, regeneration, and disease severity.
Nathalie Feeley, Kai Williams, Caitlin McCaffrey, Daniel Field, Kyle Davies, Hugh Warden, Luke Boulter, Steve Thorn, Tak Yung Man, Wei‐Yu Lu, Stephen J Wigmore, Ewen M Harrison, Stuart J Forbes, Ian P Tomlinson, Timothy J Kendall, Rachel V Guest   +15 more
wiley   +1 more source

The role of tryptophan hydroxylase‐1 in metabolic dysfunction‐associated steatotic liver disease

Pediatric Investigation, EarlyView.
Silencing hepatic tryptophan hydroxylase 1 (TPH1) alleviated diet‐induced steatotic liver disease by reducing lipid accumulation, oxidative stress, inflammation, fibrosis, and hepatocyte apoptosis. These protective effects were mediated, at least in part, through restoration of Parkin‐dependent mitochondrial autophagy, identifying hepatic TPH1 as a ...
Shuangzhen Jia, Xiaolin Ye, Zhaoxia Wang, Jie Wu   +3 more
wiley   +1 more source

Diagnosis of Portal Hypertension: Advancing Towards Non‐Invasive Solutions

Portal Hypertension &Cirrhosis, EarlyView.
This review systematically summarizes a full spectrum of non‐invasive diagnostic approaches for portal hypertension (PH), including imaging modalities, elastography, serum biomarkers, composite scoring systems and endoscopic ultrasound‐guided portal pressure gradient (EUS‐PPG), and analyzes their performance across different liver disease etiologies ...
Lijia Yin, Huikuan Chu, Ling Yang
wiley   +1 more source