Results 171 to 180 of about 387,299 (303)

Epigenetic Regulation of Liver Fibrosis: Mechanisms and Therapeutic Implications

Portal Hypertension &Cirrhosis, EarlyView.
This review synthesizes the epigenetic mechanisms—DNA methylation, histone modifications, and non‐coding RNAs—that drive hepatic stellate cell activation and the progression of liver fibrosis. It further evaluates emerging therapeutic strategies targeting these epigenetic regulators, including DNA methyltransferase and histone deacetylase inhibitors ...
Maryam Jadid Tavaf, Mahboobeh Ebrahimi Varkiani, Saeid Abroun, Pedram Asadi‐Sarabi, Shukoofeh Torabi, Elham Rismani, Mohammad Majd Hammour, Andreas K. Nüssler, Massoud Vosough   +8 more
wiley   +1 more source

Cordycepin Alleviates Non Alcoholic Fatty Liver Disease Progression by Stabilizing GCH1 to Inhibit Ferroptosis

Phytotherapy Research, EarlyView.
COR stabilizes GCH1 and inhibits ferroptosis. ABSTRACT To investigate the effects and targets of cordycepin (COR) in alleviating non‐alcoholic fatty liver disease (NAFLD). High‐fat diet was used to induce NAFLD in mice, and after COR gavage administration, changes in liver function, glucose and lipid metabolism, and ferroptosis‐related signaling were ...
Chenyang Han, Jian Sheng, Hongyan Pei, Wenyan Li, Shasha Wu, Yi Yang, Chenxi Cao, Zhiling Tang   +7 more
wiley   +1 more source

Catechins and Their Effect on the Gut Microbiome in Health and Cancer

Phytotherapy Research, EarlyView.
ABSTRACT Catechins are a group of flavonoids found primarily in green tea, fruits, and berries; they play a significant role in the modulation of the gut microbiota, thereby having an impact on gut health and cancer prevention. Owing to their low bioavailability, catechins are transformed by the gut microbiota into various bioactive metabolites such as
Prakash Monika, Bindu Sadanandan, Honnamachanahalli Ramachandraiah Tejashree, Maitreyi Darbha, Kirti Gupta, Srinivas Reneeka   +5 more
wiley   +1 more source

Correction: Empagliflozin attenuates dexamethasone-induced non-alcoholic steatohepatitis by regulation of ferroptosis, inflammation and autophagy. [PDF]

Front Pharmacol
Alharbi NS, Abdelmageed ME, Nader MA, Serrya MS.   +3 more
europepmc   +2 more sources

Liquiritigenin Ameliorates High‐Fat Diet‐Induced Hepatic Steatosis by Promoting Lipid Droplet Catabolism via PLIN2‐ATGL Regulation

Phytotherapy Research, EarlyView.
Liquiritigenin promotes expression of CGI‐58 and enhances lipolysis by down‐regulating expression of PLIN2, thereby facilitating the catabolism of larger‐sized lipid droplets and producing smaller‐sized lipid droplets, resulting in enhanced activity of lipophagy and ameliorated hepatic steatosis. ABSTRACT Metabolic‐associated fatty liver disease (MAFLD)
Zhuoya Xu, Jingmiao Chen, Hong Qin, Yansong Fu, Cunqi Lv, Zhipeng Wang, Xi Liu, Wenya Zheng   +7 more
wiley   +1 more source

Oxypaeoniflorin Attenuates Alcohol‐Associated Liver Disease, Potentially Involving TEAD4‐Mediated Inflammatory Signaling Cascades

Phytotherapy Research, EarlyView.
Oxypaeoniflorin (Opae) alleviates alcohol‐associated liver disease (ALD) by suppressing the TEAD4‐NLRP3 transcriptional axis. In hepatocytes, Opae inhibits YAP/TEAD4‐mediated NLRP3 inflammasome activation, thereby downregulating Lipin1/Srebp1‐associated lipid dysregulation.
Jiang‐Tao Zhong, Hao Yue, Ze‐Hao Wang, Ming Liu, Hai‐Ming Sun, Jian Song   +5 more
wiley   +1 more source

Inhibition of connexin hemichannels alleviates non-alcoholic steatohepatitis in mouse

, 2017
Inhibition of connexin hemichannels alleviates non-alcoholic steatohepatitis in ...
B Cogliati (13303395), L Leybaert (15835547), TC da Silva (15835535), VM Govoni (15835538), I Leclercq (13303392), IVA Pereira (15835532), SC Yanguas (15835541), RM Rodrigues (15835544), M Vinken (15835550), M Maes (13320648), J Willebrords (13303368), E Decrock (13303386)   +11 more
core  

HSPE1 deficiency underlies the crosstalk between metabolic dysfunction‐associated steatotic liver disease and age‐related macular degeneration

VIEW, EarlyView.
Rare‐earth ions act as multifunctional modifiers in perovskite solar cells by improving charge transport, suppressing oxygen vacancies, passivating defects, promoting grain growth, and enabling redox‐mediated stabilization. In addition, RE‐doped layers can expand spectral utilization through upconversion and downconversion, thereby enhancing light ...
Jiaqi Meng, Alimire Maihemuti, Yuan Yuan, Chao Chen, Mengchao Zhu, Hao Wang, Furong Zhu, Zhaodi Che, Jia Xiao, Xiangjia Zhu   +9 more
wiley   +1 more source

Imaging of Abdominal Complications in Children With Acute Lymphoblastic Leukaemia

Journal of Medical Imaging and Radiation Oncology, EarlyView.
ABSTRACT Acute lymphoblastic leukaemia (ALL) is the most common paediatric malignancy and remains one of the most common causes of cancer‐related death in children and adolescents. Five‐year overall survival rates now exceed 90% with current multidrug chemotherapeutic regimens. This improvement, coupled with the toxicity of chemotherapy, has led to the
Luke R. Holmes, Rishi S. Kotecha, Derek J. Roebuck   +2 more
wiley   +1 more source

A new marker for lipid peroxidation: Serum paraoxonase activity in non-alcoholic steatohepatitis

, 2005
Background/aims: Relationship between hepatic antioxidant paraoxonase 1 (PON1) activity, lipid peroxidation and liver injury was investigated in patients with non-alcoholic steatohepatitis.
Yücesoy, Mehmet, BAŞKOL, MEVLÜT, DENİZ, KEMAL, BAŞKOL, GÜLDEN, ÖZBAKIR, ÖMER   +4 more
core   +1 more source