Results 31 to 40 of about 387,299 (303)

Circulating TREM2 as a noninvasive diagnostic biomarker for NASH in patients with elevated liver stiffness

Hepatology, EarlyView., 2022
Abstract Background and Aims Reliable noninvasive biomarkers are an unmet clinical need for the diagnosis of NASH. This study investigates the diagnostic accuracy of the circulating triggering receptor expressed on myeloid cells 2 (plasma TREM2) as a biomarker for NASH in patients with NAFLD and elevated liver stiffness.
Vineesh Indira Chandran, Charlotte Wilhelmina Wernberg, Mette Munk Lauridsen, Maria Kløjgaard Skytthe, Sofie Marchsteiner Bendixen, Frederik Tibert Larsen, Camilla Dalby Hansen, Lea Ladegaard Grønkjær, Majken Storm Siersbæk, Tina Di Caterino, Sönke Detlefsen, Holger Jon Møller, Lars Grøntved, Kim Ravnskjaer, Søren Kragh Moestrup, Maja Sofie Thiele, Aleksander Krag, Jonas Heilskov Graversen   +17 more
wiley   +1 more source

Activation of thyroid hormone receptor‐β improved disease activity and metabolism independent of body weight in a mouse model of non‐alcoholic steatohepatitis and fibrosis

British Journal of Pharmacology, 2021
Activation of hepatic thyroid hormone receptor β (THR‐β) is associated with systemic lipid lowering, increased bile acid synthesis, and fat oxidation. In patients with non‐alcoholic steatohepatitis (NASH), treatment with THR‐β agonists decreased hepatic ...
A. Kannt, P. Wohlfart, A. N. Madsen, S. Veidal, M. Feigh, D. Schmoll   +5 more
semanticscholar   +1 more source

Insulin sensitisers in the treatment of non-alcoholic fatty liver disease : a systematic review [PDF]

, 2011
Non-alcoholic fatty liver disease (NAFLD) is closely linked with obesity and the prevalence of NAFLD is about 17% to 33% in the Western world. There is a strong association of NAFLD with insulin resistance and, hence, insulin sensitisers have been tried.
C Clar, Henderson, R., Gurung, T., N Waugh, N Sattar, N Ghouri, Clar, C., Sattar, Naveed, Sattar, N., Fraser, A., T Gurung, Gurung, T. (Tara), D Shyangdan, A Fraser, Shyangdan, D., D Preiss, Waugh, Norman, Shyangdan, D. (Deepson), R Henderson, Ghouri, N., Preiss, D., Waugh, N.   +21 more
core   +1 more source

Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial

The Lancet, 2014
Summary Background The bile acid derivative 6-ethylchenodeoxycholic acid (obeticholic acid) is a potent activator of the farnesoid X nuclear receptor that reduces liver fat and fibrosis in animal models of fatty liver disease. We assessed the efficacy of
B. Neuschwander‐Tetri, R. Loomba, A. Sanyal, J. Lavine, M. V. Van Natta, M. Abdelmalek, N. Chalasani, S. Dasarathy, A. Diehl, B. Hameed, K. Kowdley, A. McCullough, N. Terrault, J. Clark, J. Tonascia, E. Brunt, D. Kleiner, E. Doo   +17 more
semanticscholar   +1 more source

Lack of VMP1 impairs hepatic lipoprotein secretion and promotes non-alcoholic steatohepatitis

Journal of Hepatology, 2022
Background & Aims: Vacuole membrane protein 1 (VMP1) is an endoplasmic reticulum (ER) transmembrane protein that regulates the formation of autophagosomes and lipid droplets.
Xiaoxiao Jiang, S. Fulte, Feng-Yan Deng, Shi-Yuan Chen, Yan Xie, Xiaojuan Chao, Xi C. He, Yuxia Zhang, Tian-Gang Li, Feng Li, Colin S. McCoin, E. Morris, J. Thyfault, Wanqing Liu, Lin-Heng Li, N. Davidson, Wen-Xing Ding, Hong-Min Ni   +17 more
semanticscholar   +1 more source

Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression

Hepatology, EarlyView., 2022
Improved mitochondrial activity, due to the lack of methylation‐controlled J protein (MCJ), creates a specific microbiota signature that when transferred through cecal microbiota transplantation delays NASH progression by restoring the gut‐liver axis and enhancing hepatic fatty acid oxidation.
María Juárez‐Fernández, Naroa Goikoetxea‐Usandizaga, David Porras, María Victoria García‐Mediavilla, Miren Bravo, Marina Serrano‐Maciá, Jorge Simón, Teresa C. Delgado, Sofía Lachiondo‐Ortega, Susana Martínez‐Flórez, Óscar Lorenzo, Mercedes Rincón, Marta Varela‐Rey, Leticia Abecia, Héctor Rodríguez, Juan Anguita, Esther Nistal, María Luz Martínez‐Chantar, Sonia Sánchez‐Campos   +18 more
wiley   +1 more source

Diagnosis of Non-alcoholic fatty liver disease

Journal of Pathology of Nepal, 2016
Non Alcoholic Fatty Liver Disease is the deposition of fat in liver in absence of excessive of alcohol consumption. Non Alcoholic Fatty Liver Disease ranges from simple steatosis to Nonalcoholic steatohepatitis and cirrhosis.
Geetika K.C.
doaj   +1 more source

Structure of anaemic conditions comorbid to alcoholic and non-alcoholic steatohepatitis

Journal of Education, Health and Sport, 2021
The retrospective analysis of 378 medical records of inpatients with steatohepatitis (SH) depending on its etiology was performed to identify and study the type of anaemic conditions (AC).
Oksana Khukhlina, Tetiana Antofiichuk, Mykola Antofiichuk   +2 more
doaj   +1 more source

Microbial DNA enrichment promotes liver steatosis and fibrosis in the course of non-alcoholic steatohepatitis

Acta Physiologica, 2022
Low‐grade inflammation is the hallmark of non‐alcoholic fatty liver diseases (NAFLD) and non‐alcoholic steatohepatitis (NASH). The leakage of microbiota‐derived products can contribute to liver inflammation during NAFLD/NASH development.
Zhenlong Luo, Yudong Ji, Dinghong Zhang, Hong Gao, Zhongmou Jin, Meixiang Yang, Wei Ying   +6 more
semanticscholar   +1 more source

The SOD2 C47T polymorphism influences NAFLD fibrosis severity: evidence from case-control and intra-familial allele association studies. [PDF]

, 2011
AIMS: Non-alcoholic fatty liver disease (NAFLD) is a complex disease trait where genetic variations and environment interact to determine disease progression.
Patch, Julia, J. Patch, Ann K. Daly, J. B. S. Leathart, Quentin M. Anstee, Julian B.S. Leathart, Julia Patch, Christopher P. Day, Nobili, Valerio, Valerio Nobili, Anna Fracanzani, Silvia Fargion, Q. M. Anstee, Leathart, Julian B S, Day, Christopher P, Daly, Ann K, L. Valenti, Ahmad Al-Serri, S. Fargion, Paola Dongiovanni, Al Serri, Ahmad, Anstee, Quentin M, Fracanzani, Anna, Dongiovanni, Paola, C. P. Day, A. Fracanzani, A. Al Serri, V. Nobili, A. K. Daly, Valenti, Luca, P. Dongiovanni, Luca Valenti, Fargion, Silvia   +32 more
core   +1 more source