Results 41 to 50 of about 387,299 (303)

Extracellular vesicles in non-alcoholic and alcoholic fatty liver diseases

Liver Research, 2018
Fatty liver diseases, non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD) are the most common causes of chronic liver diseases around the world.
Akiko Eguchi, Ariel E. Feldstein
doaj   +1 more source

Bile acids contribute to the development of non-alcoholic steatohepatitis in mice

JHEP Reports, 2021
Background & Aims Through FXR and TGR5 signaling, bile acids (BAs) modulate lipid and glucose metabolism, inflammation and fibrosis. Hence, BAs returning to the liver after enteric secretion, modification and reabsorption may contribute to the ...
Justine Gillard, Laure-Alix Clerbaux, M. Nachit, C. Sempoux, B. Staels, L. Bindels, A. Tailleux, I. Leclercq   +7 more
semanticscholar   +1 more source

Mitochondrial stress in advanced fibrosis and cirrhosis associated with chronic hepatitis B, chronic hepatitis C, or nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Adaptive mitochondrial mechanisms allow mitochondrial resilience and prevent the worsening of fibrosis, while deregulation of these mechanisms promotes the progression from no/minimal‐mild (F0‐F2) fibrosis to advanced fibrosis and cirrhosis (F3‐F4). Abstract Background and Aims Hepatitis B virus (HBV) infection causes oxidative stress (OS) and alters ...
Dimitri Loureiro, Issam Tout, Stéphanie Narguet, Cheikh Mohamed Bed, Morgane Roinard, Ahmad Sleiman, Nathalie Boyer, Nathalie Pons‐Kerjean, Corinne Castelnau, Nathalie Giuly, Dorothy Tonui, Vassili Soumelis, Jamel El Benna, Patrick Soussan, Richard Moreau, Valérie Paradis, Abdellah Mansouri, Tarik Asselah   +17 more
wiley   +1 more source

Methionine- and choline-deficient diet induces hepatic changes characteristic of non-alcoholic steatohepatitis

Arquivos de Gastroenterologia, 2011
CONTEXT: Non-alcoholic steatohepatitis is a disease with a high incidence, difficult diagnosis, and as yet no effective treatment. So, the use of experimental models for non-alcoholic steatohepatitis induction and the study of its routes of development ...
Éder Marcolin, Luiz Felipe Forgiarini, Juliana Tieppo, Alexandre Simões Dias, Luiz Antonio Rodrigues de Freitas, Norma Possa Marroni   +5 more
doaj   +1 more source

IMAGING DIAGNOSIS OF NONALCOHOLIC STEATOHEPATITIS [PDF]

Romanian Medical Journal, 2018
Non-alcoholic fatty liver comprises several clinical entities, starting from hepatic steatosis and reaching steatohepatitis, fibrosis and liver cirrhosis; it is currently considered a major public health issue.
Anca Smaranda Farmazon, Alexandru Radu Mihailovici, Rodica Diaconu, Daniela Carmen Neagoe, Gabriel Nicolae Ianosi, Oana Sorina Tica, Maria Aurelia Buse   +6 more
doaj   +1 more source

Disease burden and economic impact of diagnosed non‐alcoholic steatohepatitis in five European countries in 2018: A cost‐of‐illness analysis

Liver international (Print), 2021
Non‐alcoholic steatohepatitis (NASH) is a chronic disease that can progress to end‐stage liver disease (ESLD). A large proportion of early‐stage NASH patients remain undiagnosed compared to those with advanced fibrosis, who are more likely to receive ...
J. Schattenberg, J. Lazarus, P. Newsome, L. Serfaty, A. Aghemo, S. Augustin, E. Tsochatzis, V. de Lédinghen, E. Bugianesi, M. Romero-Gómez, H. Bantel, S. Ryder, J. Boursier, V. Leroy, J. Crespo, L. Castéra, L. Floros, V. Atella, J. Mestre-Ferrandiz, R. Elliott, A. Kautz, A. Morgan, S. L. Sansom, S. Vasudevan, L. Pezzullo, A. Trylesinski, S. Cure, V. Higgins, V. Ratziu   +28 more
semanticscholar   +1 more source

Janus kinase 2 inhibition by pacritinib as potential therapeutic target for liver fibrosis

Hepatology, EarlyView., 2022
Diagram of the activation of the profibrotic and procontractile Janus kinase 2 (JAK2)/Ras homolog family member A/Rho‐kinase pathway and the inhibition of phosphorylated JAK2 by pacritinib to inhibit hepatic stellate cell activity. Abstract Background and Aims Janus kinase 2 (JAK2) signaling is increased in human and experimental liver fibrosis with ...
Sandra Torres, Cristina Ortiz, Nadine Bachtler, Wenyi Gu, Leon D. Grünewald, Nico Kraus, Robert Schierwagen, Christoph Hieber, Caroline Meier, Olaf Tyc, Maximilian Joseph Brol, Frank Erhard Uschner, Bart Nijmeijer, Christoph Welsch, Marie‐Luise Berres, Carmen Garcia‐Ruiz, Jose Carlos Fernandez‐Checa, Christian Trautwein, Thomas J. Vogl, Stefan Zeuzem, Jonel Trebicka, Sabine Klein   +21 more
wiley   +1 more source

Alcoholic steatohepatitis

, 2023
Alkoholni steatohepatitis predstavlja oblik alkoholom uzrokovanog oštećenja jetre, jedne od najčešćih jetrenih bolesti današnjice, koja se javlja kao posljedica dugotrajne i prekomjerne konzumacije alkohola.
Ćosić, Iva
core   +2 more sources

Lifestyle modification in NAFLD/NASH: Facts and figures

JHEP Reports, 2019
Summary: The development of non-alcoholic fatty liver disease is closely linked to lifestyle factors, namely excessive caloric intake coupled with reduced physical activity and exercise. This review aims to examine the evidence behind lifestyle change as
Kate Hallsworth, Leon A. Adams
doaj   +1 more source

The Economic Burden of Non-Alcoholic Steatohepatitis: A Systematic Review

PharmacoEconomics (Auckland), 2022
The global prevalence of non-alcoholic steatohepatitis (NASH) is increasing, such that NASH is predicted to become the leading cause of liver transplantation (LT) in the US by 2025. Despite this, data on the economic burden of NASH are limited.
Michał Witkowski, S. I. Moreno, J. Fernandes, P. Johansen, Margarida Augusto, S. Nair   +5 more
semanticscholar   +1 more source