Results 11 to 20 of about 115,651 (262)

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source

Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis

Hepatology, EarlyView., 2022
EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu, Xiude Fan, Megan R. McMullen, Tatsunori Miyata, Adam Kim, Vai Pathak, Jianguo Wu, Le Z. Day, Josiah E. Hardesty, Nicole Welch, Jaividhya Dasarathy, Daniela S. Allende, Arthur J. McCullough, Jon M. Jacobs, Daniel M. Rotroff, Srinivasan Dasarathy, Laura E. Nagy   +16 more
wiley   +1 more source

The endocannabinoid system promotes hepatocyte progenitor cell proliferation and maturation by modulating cellular energetics

Cell Death Discovery, 2023
The proliferation and differentiation of hepatic progenitor cells (HPCs) drive the homeostatic renewal of the liver under diverse conditions. Liver regeneration is associated with an increase in Axin2+Cnr1+ HPCs, along with a marked increase in the ...
Bani Mukhopadhyay, Kellie Holovac, Kornel Schuebel, Partha Mukhopadhyay, Resat Cinar, Sindhu Iyer, Cheryl Marietta, David Goldman, George Kunos   +8 more
doaj   +1 more source

Molecular Imaging of Opioid and Dopamine Systems: Insights Into the Pharmacogenetics of Opioid Use Disorders

Frontiers in Psychiatry, 2019
Opioid use in the United States has steadily risen since the 1990s, along with staggering increases in addiction and overdose fatalities. With this surge in prescription and illicit opioid abuse, it is paramount to understand the genetic risk factors and
Jamie A. Burns, Danielle S. Kroll, Dana E. Feldman, Christopher Kure Liu, Peter Manza, Corinde E. Wiers, Nora D. Volkow, Nora D. Volkow, Gene-Jack Wang   +8 more
doaj   +1 more source

Exacerbating effects of single-dose acute ethanol exposure on neuroinflammation and amelioration by GPR110 (ADGRF1) activation

Journal of Neuroinflammation, 2023
Background Neuroinflammation is a widely studied phenomenon underlying various neurodegenerative diseases. Earlier study demonstrated that pharmacological activation of GPR110 in both central and peripheral immune cells cooperatively ameliorates ...
Sharmistha Banerjee, Taeyeop Park, Yoo Sun Kim, Hee-Yong Kim   +3 more
doaj   +1 more source

Increased transcription of TSPO, HDAC2, and HDAC6 in the amygdala of males with alcohol use disorder

Brain and Behavior, 2021
Introduction Repeated exposure to high doses of alcohol triggers neuroinflammatory processes that contribute to craving and mood dysfunction in alcohol use disorder (AUD).
Luana Martins De Carvalho, Corinde E. Wiers, Hui Sun, Gene‐Jack Wang, Nora D. Volkow   +4 more
doaj   +1 more source

Social media addiction as a mediator of the associations between fear of COVID-19, mental health symptoms, and problematic alcohol use

Frontiers in Psychiatry, 2023
BackgroundFear of COVID-19 is a risk factor for anxiety and depressive symptoms. During the COVID-19 pandemic, drinking to cope with psychological distress has been proposed as a key mechanism leading to problematic drinking.
Jeremy W. Luk, Daniel W. Geda, Bethany L. Stangl, Cecilia Cheng, Melanie L. Schwandt, David Goldman, David Goldman, Nancy Diazgranados, Vijay A. Ramchandani   +8 more
doaj   +1 more source

ALCOHOL AND ALCOHOLIC INTOXICATION.* [PDF]

British Journal of Inebriety, 1920
n ...
openaire   +2 more sources

4288 Identifying Predictive Variables of High-Intensity Binge Drinking Through the Use of a Machine Learning Algorithm

Journal of Clinical and Translational Science, 2020
OBJECTIVES/GOALS: To test if a machine learning algorithm could predict a person’s capacity to binge drink and explore what measures might be important for identifying individuals at risk for high-intensity binge drinking behaviors.
James Keoni Morris, Josh L. Gowin, Melanie L. Schwandt, Nancy Diazgranados, Vijay A. Ramchandani   +4 more
doaj   +1 more source

Socioeconomic status, BMI, and brain development in children

Translational Psychiatry, 2022
Low socioeconomic status (SES) in childhood is associated with deficits in executive function and changes in cortical morphology. Furthermore, rates of childhood obesity are greater among low SES children and childhood obesity is also associated with ...
Evan Dennis, Peter Manza, Nora D. Volkow
doaj   +1 more source