Results 41 to 50 of about 310,119 (307)
Methylphenidate reorganizes cortical hierarchy through dopaminergic modulation
Nature CommunicationsDopaminergic signaling shapes large-scale brain network architecture, constraining neural communication along a principal gradient that spans unimodal sensorimotor to transmodal association cortices.
Dardo Tomasi +12 more
doaj +1 more source
Endocannabinoid-dopamine interactions in striatal synaptic plasticity
Frontiers in Pharmacology, 2012 The nigrostriatal dopaminergic system is implicated in action control and learning. A large body of work has focused on the contribution of this system to modulation of the corticostriatal synapse, the predominant synapse type in the striatum ...
Brian Neil Mathur, David M Lovinger
doaj +1 more source
Cellular and Molecular Gastroenterology and Hepatology, 2022 Background & Aims: Nonalcoholic steatohepatitis (NASH) is a leading cause of chronic liver disease, characterized by steatosis and hallmark liver neutrophil infiltration.
Robim M. Rodrigues +14 more
doaj +1 more source
Leverage and Alcohol Addiction [PDF]
, 2012 This paper confronts the question of whether messages can be diluted or even contradicted by the format in which they are delivered through a textual analysis of the TNT procedural drama Leverage, examining the portrayal of alcoholism in the program. The
Gallagher, Tom
core +1 more source
Noninvasive Focal Gene Delivery into the Cerebellum of Non‐Human Primates using Focused Ultrasound
Advanced Science, EarlyView.Focal and non‐invasive viral vector delivery in non‐human primates remains a major challenge in translational neuroscience. Low‐intensity focused ultrasound was used to transiently open the blood–brain barrier and enable targeted gene delivery to the cerebellum.
Noelia Esteban‐García +11 more
wiley +1 more source
GPR110 (ADGRF1) mediates anti-inflammatory effects of N-docosahexaenoylethanolamine
Journal of Neuroinflammation, 2019 Background Neuroinflammation is a widely accepted underlying condition for various pathological processes in the brain. In a recent study, synaptamide, an endogenous metabolite derived from docosahexaenoic acid (DHA, 22:6n-3), was identified as a ...
Taeyeop Park, Huazhen Chen, Hee-Yong Kim
doaj +1 more source
Frontiers in Endocrinology, 2021 Scleroderma, or systemic sclerosis, is a multi-organ connective tissue disease resulting in fibrosis of the skin, heart, and lungs with no effective treatment. Endocannabinoids acting via cannabinoid-1 receptors (CB1R) and increased activity of inducible
Charles N. Zawatsky +8 more
doaj +1 more source
Gambling addiction and life meaning
, 1999 Addictive Gambling has plagued mankind for thousands of years. However, it has only recently been studied extensively. One proposed cause for addiction, which has been used in studying alcohol and drug abuse, is a lack of meaning in the addict\u27s life.
Plesh, Andrew Bohdan
core +1 more source
Annals of Gastroenterological Surgery, EarlyView.Alcohol relapse after liver transplantation is difficult to predict using abstinence duration alone. We developed a multifactor model integrating abstinence duration, psychosocial risk (SIPAT), and socioeconomic context (AUC 0.70). This approach may support individualized risk assessment and tailored follow‐up intensity; external validation is needed ...
Ayato Obana +9 more
wiley +1 more source
Cannabis Affects Cerebellar Volume and Sleep Differently in Men and Women
Frontiers in Psychiatry, 2021 Background: There are known sex differences in behavioral and clinical outcomes associated with drugs of abuse, including cannabis. However, little is known about how chronic cannabis use and sex interact to affect brain structure, particularly in ...
Katherine L. McPherson +5 more
doaj +1 more source