Results 41 to 50 of about 154,955 (297)

E-Selectin-Dependent Inflammation and Lipolysis in Adipose Tissue Exacerbate Steatosis-to-NASH Progression via S100A8/9Summary

Cellular and Molecular Gastroenterology and Hepatology, 2022
Background & Aims: Nonalcoholic steatohepatitis (NASH) is a leading cause of chronic liver disease, characterized by steatosis and hallmark liver neutrophil infiltration.
Robim M. Rodrigues, Yong He, Seonghwan Hwang, Adeline Bertola, Bryan Mackowiak, Yeni Ait Ahmed, Wonhyo Seo, Jing Ma, Xiaolin Wang, Seol Hee Park, Yukun Guan, Yaojie Fu, Tamara Vanhaecke, Dechun Feng, Bin Gao   +14 more
doaj   +1 more source

Alcoholism Matters [PDF]

, 1976
Newsletter of the Texas Commission on Alcoholism providing updates the agency and their programs along with news, events, and other information related to addiction prevention and ...
Knief, Mary Kay, Texas Commission on Alcoholism   +1 more
core  

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Cannabis Affects Cerebellar Volume and Sleep Differently in Men and Women

Frontiers in Psychiatry, 2021
Background: There are known sex differences in behavioral and clinical outcomes associated with drugs of abuse, including cannabis. However, little is known about how chronic cannabis use and sex interact to affect brain structure, particularly in ...
Katherine L. McPherson, Dardo G. Tomasi, Gene-Jack Wang, Peter Manza, Nora D. Volkow, Nora D. Volkow   +5 more
doaj   +1 more source

Boundary‐Dependent Sleep–Wake Dysregulation in Idiopathic Hypersomnia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Idiopathic hypersomnia (IH) presents with excessive daytime sleepiness (EDS) despite apparently preserved nocturnal sleep, challenging traditional models of hypersomnolence based on sleep loss or fragmentation. We aimed to test the hypothesis that EDS in IH reflects excessive stabilization of the sleep state, consistent with ...
Samantha Mombelli, Karine Lacourse, Hélène Blais, Anne‐Sophie Deshaies‐Rugama, Cynthia Thompson, Alex Desautels, Jacques Montplaisir, Milan Nigam, Christophe Moderie, Boshra Khajehpiri, Catherine Duclos, Jean Marc Lina, Julie Carrier, Nadia Gosselin   +13 more
wiley   +1 more source

Methylphenidate reorganizes cortical hierarchy through dopaminergic modulation

Nature Communications
Dopaminergic signaling shapes large-scale brain network architecture, constraining neural communication along a principal gradient that spans unimodal sensorimotor to transmodal association cortices.
Dardo Tomasi, Peter Manza, Şükrü Barış Demiral, Weizheng Yan, Kylee B. Miller, Faith Veenker, Joshua Zhao, Christina Lildharrie, Michele-Vera Yonga, Sarah Abey, Michaelene VanDine, Gene-Jack Wang, Nora D. Volkow   +12 more
doaj   +1 more source

MetaPaCS: A Novel Meta‐Learning Framework for Pancreatic Cancer Subtype Identification

Advanced Intelligent Systems, EarlyView.
We have developed MetaPaCS, an ensemble meta‐learning framework for reliable prediction of pancreatic cancer subtypes with high accuracy. MetaPaCS is capable of capturing subtype‐specific distinct gene expression patterns and drug‐disease associations for pancreatic cancer.
Nick B. Peterson, Mengtao Sun, Xinchao Wu, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Flupenthixol in relapse prevention in schizophrenics with comorbid alcoholism: Results from an open clinical study [PDF]

, 2003
Substance use, especially alcoholism, has been recognized as a significant problem in schizophrenic patients, though only a few studies on the effects of pharmacotherapy in these patients have been conducted so far.
Soyka, Michael, Glaser, Thomas, Aichmüller, Claus, Bardeleben, Ulrich von, Hornung-Knobel, Sybille, Wegner, Ulrike, Beneke, Manfred   +6 more
core   +1 more source

Synthetic Particulate Subunit Vaccines Co‐Delivering Multiple Antigens Induce Protective Immunity Against Melioidosis

Advanced NanoBiomed Research, EarlyView.
Engineered endotoxin‐free Escherichia coli were used to assemble poly(3‐hydroxybutyrate) (PHB) biopolymer particles displaying multiple conserved Burkholderia pseudomallei antigens via PhaC‐mediated surface presentation. Following formulation with poly(I:C), the particulate vaccines induced antigen‐specific humoral and cellular immune responses ...
Md. Tanvir Kabir, Shuxiong Chen, Justine B. Bendo, Ashley Johnson, Aleksandra W. Debowski, Mitali Sarkar‐Tyson, Bernd H. A. Rehm   +6 more
wiley   +1 more source

Alcohol. [PDF]

BMJ, 1982
Abstract There is evidence for a dose-response relationship between alcohol consumption and risk of liver cirrhosis, cancers of the oropharynx, larynx, oesophagus, rectum (beer only), liver, and female breast, and violent death, but the relationship between alcohol consumption and cardiovascular disease is more complex.
openaire   +2 more sources