Results 51 to 60 of about 154,955 (297)
Tackling cancer stemness with nanotechnology in the era of precision medicine
BMEMat, EarlyView.Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo +9 more
wiley +1 more source
Frontiers in Endocrinology, 2021 Scleroderma, or systemic sclerosis, is a multi-organ connective tissue disease resulting in fibrosis of the skin, heart, and lungs with no effective treatment. Endocannabinoids acting via cannabinoid-1 receptors (CB1R) and increased activity of inducible
Charles N. Zawatsky +8 more
doaj +1 more source
BMEMat, EarlyView.Engineered bacteria serve as smart, living therapeutics that target tumors, deliver drugs, and remodel immunosuppressive microenvironments. This review highlights their potential to potentiate immunotherapy, radiotherapy, and chemotherapy, offering a promising paradigm for precise and synergistic cancer treatment. Abstract The dynamic interplay between
Haonan Shen +9 more
wiley +1 more source
Endocannabinoid-dopamine interactions in striatal synaptic plasticity
Frontiers in Pharmacology, 2012 The nigrostriatal dopaminergic system is implicated in action control and learning. A large body of work has focused on the contribution of this system to modulation of the corticostriatal synapse, the predominant synapse type in the striatum ...
Brian Neil Mathur, David M Lovinger
doaj +1 more source
Customized three dimensionally printed palatal stents: A randomized controlled clinical trial
Clinical Advances in Periodontics, EarlyView.Abstract Background Soft tissue grafts are commonly used in periodontal surgery around teeth and implants. However, few studies have examined donor‐site pain through patient‐reported outcomes following soft tissue grafting. This study aimed to minimize donor‐site pain during autologous gingival grafting using a three‐dimensionally (3D)‐printed stent ...
Mi‐Seon Goh +4 more
wiley +1 more source
iScience, 2023 Summary: Activation of adhesion receptor GPR110 by the endogenous ligand synaptamide promotes neurogenesis, neurite growth, and synaptogenesis in developing brains through cAMP signal transduction.
Bill X. Huang +6 more
doaj +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Although sodium‐glucose cotransporter‐2 inhibitors (SGLT2i) are recommended for patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD), concerns regarding urogenital infections persist. Therefore, we evaluated the risk of urinary tract infection (UTI) and genital tract infection (GTI) after SGLT2i initiation in this population ...
Young‐Mi Ah +4 more
wiley +1 more source
Motor cortex somatostatin interneurons adaptively shape the structure of action sequences
Nature CommunicationsThe brain flexibly reorganizes action sequences to optimize behavioral outcomes through reinforcement learning and adaptive motor control. Although the primary motor cortex (M1) is essential for skill learning and dexterous movement, how cortical ...
Jeong Oen Lee +4 more
doaj +1 more source
Drug Testing and Analysis, EarlyView.Higher uEtG results indicated more recent drinking, rather than higher levels of alcohol consumption, and the period of detection of uEtG was shorter than previously reported. Even at low cutoffs, uEtG was best conceptualized as a measure of alcohol consumption in the prior 24 h.
Julianne D. Jett +10 more
wiley +1 more source