Results 31 to 40 of about 118,083 (262)
Endocannabinoid-dopamine interactions in striatal synaptic plasticity
Frontiers in Pharmacology, 2012 The nigrostriatal dopaminergic system is implicated in action control and learning. A large body of work has focused on the contribution of this system to modulation of the corticostriatal synapse, the predominant synapse type in the striatum ...
Brian Neil Mathur, David M Lovinger
doaj +1 more source
Chemoselective Metabolomics via a Modular Reactivity‐Encoding Platform
Advanced Science, EarlyView.Conventional LC–MS underrepresents numerous metabolites due to heterogeneous ionization efficiencies and matrix interference. Here, we introduce a modular reactivity‐encoding platform (MREP) comprising four alkyne‐tagged probes that selectively derivatize key functional groups, followed by unified click‐chemistry capture to eliminate matrix components ...
Xin Tao +10 more
wiley +1 more source
Cellular and Molecular Gastroenterology and Hepatology, 2022 Background & Aims: Nonalcoholic steatohepatitis (NASH) is a leading cause of chronic liver disease, characterized by steatosis and hallmark liver neutrophil infiltration.
Robim M. Rodrigues +14 more
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American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.ABSTRACT Major depression and suicide are critical public health concerns, particularly in underrepresented populations with unique genetic and sociocultural contexts. The Maya‐mestizo population presents the highest suicide rates in the country but remains understudied in psychiatric genetics. This study evaluated the association between three genetic
Marta Menjivar +3 more
wiley +1 more source
Frontiers in Endocrinology, 2021 Scleroderma, or systemic sclerosis, is a multi-organ connective tissue disease resulting in fibrosis of the skin, heart, and lungs with no effective treatment. Endocannabinoids acting via cannabinoid-1 receptors (CB1R) and increased activity of inducible
Charles N. Zawatsky +8 more
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Berichte zur Wissenschaftsgeschichte, EarlyView.This article will analyze the uncertainties around collecting and classifying Hydnora africana in the first half of the nineteenth century. Emerging from the distinctive dryland ecologies of South Africa, Hydnora was interpreted as strange and cryptic by Europeans primarily because it is a root parasite—a complex floral trait that was little understood.
Katherine Arnold
wiley +1 more source
Seasonal effect—an overlooked factor in neuroimaging research
Translational Psychiatry, 2023 In neuroimaging research, seasonal effects are often neglected or controlled as confounding factors. However, seasonal fluctuations in mood and behavior have been observed in both psychiatric disorders and healthy participants.
Rui Zhang +2 more
doaj +1 more source
iScience, 2023 Summary: Activation of adhesion receptor GPR110 by the endogenous ligand synaptamide promotes neurogenesis, neurite growth, and synaptogenesis in developing brains through cAMP signal transduction.
Bill X. Huang +6 more
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Tackling cancer stemness with nanotechnology in the era of precision medicine
BMEMat, EarlyView.Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo +9 more
wiley +1 more source