Results 21 to 30 of about 256,760 (299)

Identification of Key Residues for Enzymatic Carboxylate Reduction

Frontiers in Microbiology, 2018
Carboxylate reductases (CARs, E.C. 1.2.1.30) generate aldehydes from their corresponding carboxylic acid with high selectivity. Little is known about the structure of CARs and their catalytically important amino acid residues.
Holly Stolterfoht, Holly Stolterfoht, Georg Steinkellner, Georg Steinkellner, Daniel Schwendenwein, Tea Pavkov-Keller, Tea Pavkov-Keller, Karl Gruber, Karl Gruber, Margit Winkler, Margit Winkler   +10 more
doaj   +1 more source

Aldehyde dehydrogenase 1A1 and gelsolin identified as novel invasion-modulating factors in conditioned medium of pancreatic cancer cells [PDF]

, 2008
Conditioned medium (CM) from clonal sub-populations of the pancreatic cancer cell line, MiaPaCa-2 with differing invasive abilities, were examined for their effect on in vitro invasion.
Naomi Walsh, Martin Clynes, Clynes, Martin, O'Donovan, Norma, Michael Henry, Walsh, Naomi, Dowling, Paul, Paula Meleady, Meleady, Paula, Norma O'Donovan, O\u27Donovan, Norma, Henry, Michael, Paul Dowling   +12 more
core   +2 more sources

ALDH2 mediates 5-nitrofuran activity in multiple species [PDF]

, 2012
Understanding how drugs work in vivo is critical for drug design and for maximizing the potential of currently available drugs. 5-nitrofurans are a class of pro-drugs widely used to treat bacterial and trypanosome infections, but despite relative ...
Spitzer, Michaela, Brear, Paul, Patton, E. Elizabeth, Johnson, Stephen L, Patton, E Elizabeth, Zeng, Zhiqiang, Patton, Elizabeth, Mitchell, Amy, Ishizaki, Hironori, Taylor, Kerrie L, Johnson, Stephen L., Taylor, Kerrie L., Smith, Terry K., Westwood, Nicholas J, Patton, E Elizabeth; id_orcid, Marie, K.L.; id_orcid, McNeil, Ewan, Temperley, Nicholas, Tyers, Mike, Melton, David W, Zhou, Linna, Temperley, Nicholas D., Temperley, Nicholas D, Gautier, Philippe, Taylor, Kerrie, Narayan, Vikram, Melton, David, Westwood, Nicholas James, Melton, David W., Smith, Terry K, Johnson, Stephen, McNeil, Ewan M, McNeil, Ewan M., Westwood, Nicholas J.   +33 more
core   +1 more source

Aldehyde-mediated inhibition of asparagine biosynthesis has implications for diabetes and alcoholism

Patients with alcoholism and type 2 diabetes manifest altered metabolism, including elevated aldehyde levels and unusually low asparagine levels. We show that asparagine synthetase B (ASNS), the only human asparagine-forming enzyme, is inhibited by ...
Felix A Dingler (9638552), John Walsby-Tickle (11566535), Christopher L Millington (9638558), Ketan J Patel (9638603), James SO McCullagh (10283798), Nadia Saffoon (10675887), Christopher J Schofield (8307249), Tobias John (8411745), Svenja S Hester (17826992), Richard J Hopkinson (8273532)   +9 more
core   +6 more sources

RuCl3·3H2O Catalyzed Reactions: Facile Synthesis of Bis(indolyl)methanes under Mild Conditions

Molecules, 2011
RuCl3·3H2O was found to be an effective catalyst for reactions of indoles, 2-methylthiophene, and 2-methylfuran with aldehydes to afford the corresponding bis(indolyl)methanes, bis(thienyl)methanes, and bis(fur-2-yl)methanes in moderate to excellent ...
Liang-Xian Liu, Qiao-Sheng Hu, Kai-Hui Yu, Ning Wang, Chen Xiao, Hong-En Qu   +5 more
doaj   +1 more source

Copper-catalyzed enantioselective conjugate addition of organometallic reagents to challenging Michael acceptors

Beilstein Journal of Organic Chemistry, 2020
The copper-catalyzed enantioselective conjugate addition (ECA) of organometallic nucleophiles to electron-deficient alkenes (Michael acceptors) represents an efficient and attractive methodology for providing a wide range of relevant chiral molecules. In
Delphine Pichon, Jennifer Morvan, Christophe Crévisy, Marc Mauduit   +3 more
doaj   +1 more source

Chiral Aldehyde Catalysis Enables Direct Asymmetric Substitution Reaction of N-Unprotected Amino Acids with Halohydrocarbons [PDF]

, 2023
The direct catalytic hydrocarbylation of readily available amino acids with halohydrocarbons is one of the most straightforward methods leading to disubstituted non-proteinogenic amino acid compounds.
Rong-Xing, He, Chao-Xing, Li, Wei, Wen, Zhu-Lian, Wu, Xin, Jiang, Tian, Cai, Jian-Hua, Liu, Fang, Zhu, Hao-Ran, Shen, Yao, Lin, Qi-Xiang, Guo   +10 more
core   +2 more sources

1,3-Dipolar Cycloaddition Reactions of Azomethine Ylides with Carbonyl Dipolarophiles Yielding Oxazolidine Derivatives

Molecules, 2016
We provide a comprehensive account of the 1,3-dipolar cycloaddition reactions of azomethine ylides with carbonyl dipolarophiles. Many different azomethine ylides have been studied, including stabilized and non-stabilized ylides.
Adam G. Meyer, John H. Ryan
doaj   +1 more source

A rapid, easy, and efficient method for synthesis of 4,4'-(arylmethylene)-bis-(1H-pyrazol-5-ols), catalyzed by boehmite nanoparticles [PDF]

شیمی کاربردی روز, 2016
An efficient and eco-friendly method is introduced for the synthesis of 4,4'-(arylmethylene)-bis-(1H-pyrazol-5-ols) by the condensation reaction of two equivalents of 5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one with various aromatic aldehydes ...
محمد باخرد, علی کیوانلو, امیرحسین امین, راحله دوستی, زهرا آقایان   +4 more
doaj   +1 more source

Interaction of Amines with Ketone Aldehydes and Unsaturated Aldehydes [PDF]

Proceedings of the National Academy of Sciences, 1973
The optical changes occurring during the interaction of amines with ketone aldehydes or unsaturated aldehydes are accompanied by strong electron spin resonance signals, and can thus be explained as due to the transfer of one whole electron in the ground state.
H, Kon, A, Szent-Györgyi
openaire   +2 more sources