Results 31 to 40 of about 411,018 (337)

TRP Channels as Sensors of Aldehyde and Oxidative Stress

Biomolecules, 2021
The transient receptor potential (TRP) cation channel superfamily comprises more than 50 channels that play crucial roles in physiological processes. TRP channels are responsive to several exogenous and endogenous biomolecules, with aldehydes emerging as
Katharina E. M. Hellenthal, Laura Brabenec, Eric R. Gross, Nana-Maria Wagner   +3 more
doaj   +1 more source

Danishefsky’s Diene vs Rawal’s Diene in [4+2] Hetero-Diels-Alder Reactions with Aldehydes

Журнал органічної та фармацевтичної хімії
The Diels-Alder reaction remains one of the most versatile and widely employed cycloaddition strategies in synthetic organic chemistry. The development of functionalized dienes, particularly Danishefsky’s diene (DD) and Rawal’s diene (RD), has ...
Oleksii I. Shamrai, Evgenij V. Zarudnitskii   +1 more
doaj   +1 more source

Proteomic Profiling, Transcription Factor Modeling, and Genomics of Evolved Tolerant Strains Elucidate Mechanisms of Vanillin Toxicity in Escherichia coli

mSystems, 2019
Vanillin (4-hydroxy-3-methoxybenzaldehyde) is an economically important flavor compound that can be made in bacterial cell factories, but toxicity is a major problem for cells producing this aromatic aldehyde.
Calum A. Pattrick, Joseph P. Webb, Jeffrey Green, Roy R. Chaudhuri, Mark O. Collins, David J. Kelly   +5 more
doaj   +1 more source

Activity coefficients for liquid organic reactions : towards a better understanding of true kinetics with the synthesis of jasmin aldehyde as showcase [PDF]

, 2019
The aldol condensation of benzaldehyde and heptanal is taken as an example of reversible liquid phase organic reactions to show that inclusion of activity coefficients reveal distinct differences in conversion and product distribution when different ...
Heynderickx, Philippe
core   +1 more source

Flexible access to conformationally-locked bicyclic morpholines [PDF]

, 2013
A preparatively accessible route to a series of conformationally-locked bicyclic morpholines has been developed. This flexible approach allows for diversification in order for a small array of lead-like scaffolds to be synthesised from readily available ...
Brawn, Brice, Chen, Dow, Duncan M. Gill, Furber, Garrison, Ito, John A. Parkinson, Kilonda, Laura C. Paterson, Long, MacLellan, Rachael Bogacki, Sayago, Scott Lamont, Smith, Still, Timmer, William J. Kerr, Xiao   +20 more
core   +1 more source

Aldehyde dehydrogenase 1A1 and gelsolin identified as novel invasion-modulating factors in conditioned medium of pancreatic cancer cells [PDF]

, 2008
Conditioned medium (CM) from clonal sub-populations of the pancreatic cancer cell line, MiaPaCa-2 with differing invasive abilities, were examined for their effect on in vitro invasion.
Alban, Albini, Altmeyer, Bendtsen, Bhave, Chaponnier, Collard, Cunningham, Dosaka-Akita, Faivre, Ferlay, Goggins, Han, Holdenrieder, Jelski, Jelski, Jemal, Koya, Kulasingam, Kumar, Kuramitsu, Kwiatkowski, Kwiatkowski, Lee, Lundin, Martin, Martin Clynes, Michael Henry, Moreb, Naomi Walsh, Negm, Ni, Norma O'Donovan, Noske, Okano, Orchekowski, Paul Dowling, Paula Meleady, Safi, Sagawa, Shieh, Sladek, Tanaka, Tanaka, Tanudji, Tempero, Thompson, Thor, Wang, Winston, Yin, Yoshida   +51 more
core   +3 more sources

Identification of Key Residues for Enzymatic Carboxylate Reduction

Frontiers in Microbiology, 2018
Carboxylate reductases (CARs, E.C. 1.2.1.30) generate aldehydes from their corresponding carboxylic acid with high selectivity. Little is known about the structure of CARs and their catalytically important amino acid residues.
Holly Stolterfoht, Holly Stolterfoht, Georg Steinkellner, Georg Steinkellner, Daniel Schwendenwein, Tea Pavkov-Keller, Tea Pavkov-Keller, Karl Gruber, Karl Gruber, Margit Winkler, Margit Winkler   +10 more
doaj   +1 more source

Sheep liver cytosolic aldehyde dehydrogenase : a fresh perspective : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Chemistry at Massey University, New Zealand [PDF]

, 1995
The pre-steady-state mechanism of aldehyde dehydrogenase has been further investigated using synthesised deuterated 4-trans-(N,N-dimethylamino) cinnamaldehyde as a substrate.
Sime, Richard Malcolm
core  

A self optimizing synthetic organic reactor system using real-time in-line NMR spectroscopy [PDF]

, 2015
A configurable platform for synthetic chemistry incorporating an in-line benchtop NMR that is capable of monitoring and controlling organic reactions in real-time is presented.
Cronin, Leroy, Dragone, Vincenza, Porwol, Luzian, Sans Sangorrin, Victor   +3 more
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source