The Rcs system coordinately regulates the expression of the pectate lyase gene pelE and the TolC‐family outer membrane channel gene omeP to promote host cell wall degradation and enhance the tolerance of the pathogen to reactive oxygen species (ROS), hence promoting the virulence of Lonsdalea populi.
Ruirui Yang +4 more
wiley +1 more source
Expression pattern and prognostic significance of aldehyde dehydrogenase 2 in lung adenocarcinoma as a potential predictor of immunotherapy efficacy. [PDF]
Baldari S +3 more
europepmc +1 more source
Comparative Genome‐Wide Association Studies of Metabolites and Grain‐Related Traits in Common Wheat
ABSTRACT The metabolome is highly diverse and the closest layer to phenotype; therefore, it is commonly regarded as a bridge between the genome and phenome in plants. Here, we performed large‐scale metabolome analysis using liquid chromatography–tandem mass spectrometry (LC–MS/MS) and 33 grain‐related traits in a diverse panel of natural accessions and
Guoguo Lv +11 more
wiley +1 more source
ALDH Inhibition‐Primed Photocatalysis Disrupts Cancer Stemness Plasticity
DE‐Et converts ALDH‐mediated redox buffering into a photoredox vulnerability by coupling ALDH inhibition with red‐light‐driven catalytic NADH oxidation. This enzyme‐coupled photoredox strategy sustains mitochondrial NADH/NAD+ imbalance, induces pyroptotic tumor cell death, suppresses tumor growth in vivo, and promotes systemic antitumor immunity ...
Yujin Kim +10 more
wiley +2 more sources
Alcohol Consumption and the Risk of Ruptured Intracranial Aneurysms: A Differential Effect of the ALDH2 rs671 Variant-A Letter to the Editor Regarding "Aldehyde Dehydrogenase 2 Gene Mutation May Reduce the Risk of Rupture of Intracranial Aneurysm in Chinese Han Population". [PDF]
Bogahawaththa S, Matsumoto A.
europepmc +1 more source
Spatiotemporal Dynamics of Cytosolic NADPH in Living Arabidopsis thaliana
ABSTRACT In plants, an adequate supply of Nicotinamide adenine dinucleotide phosphate (NADPH) in the cytosol is crucial for maintaining a variety of biosynthetic and antioxidant reactions. Cytosolic NADPH is mainly generated via four enzymatic pathways: NADP‐dependent malic dehydrogenase (NADP‐ME), cytosolic oxidative pentose phosphate pathway (cOPPP),
Danying Lu +4 more
wiley +1 more source
Identification of Aldehyde Dehydrogenase Gene Family in <i>Glycyrrhiza uralensis</i> and Analysis of Expression Pattern Under Drought Stress. [PDF]
He M +8 more
europepmc +1 more source
Investigation of the DSF/Cu Reaction Using HR LCMS and Reactivity Studies
The generation of Cu(II)bis(diethyldithiocarbamate) from the combination of disulfiram and Cu salts, as used in many cuprototic cancer studies, is examined using high‐resolution liquid chromatography‐mass spectroscopy. By monitoring the reaction at different sampling times to determine reaction intermediates and the addition of adduct‐forming traps, a ...
Jordan Lyons, Patrick J. Farmer
wiley +1 more source
Design Considerations for Polymer–Deep Eutectic Solvent Hybrid Systems for Transdermal Drug Delivery
Deep eutectic solvents (DESs) act as tunable, green excipients that modulate polymer structure–property relationships to enhance drug solubility, skin permeation, stability, and controlled release. Through hydrogen‐bond interactions, DES–polymer hybrid systems enable improved transdermal performance, offering a rational, design‐driven platform for ...
Madhavi Kailas Kapale +3 more
wiley +1 more source
Study on the value of gastrin 17 and aldehyde dehydrogenase 1 in gastric juice for early diagnosis in gastric cancer. [PDF]
Wang Y, Liu H, Li X, Jin J, Yan B.
europepmc +1 more source

