Results 201 to 210 of about 329,736 (281)

The Rcs System Is Required for Virulence and Colonization of the Poplar Canker Bacterium Lonsdalea populi

open access: yesMolecular Plant Pathology, Volume 27, Issue 11, November 2026.
The Rcs system coordinately regulates the expression of the pectate lyase gene pelE and the TolC‐family outer membrane channel gene omeP to promote host cell wall degradation and enhance the tolerance of the pathogen to reactive oxygen species (ROS), hence promoting the virulence of Lonsdalea populi.
Ruirui Yang   +4 more
wiley   +1 more source

Comparative Genome‐Wide Association Studies of Metabolites and Grain‐Related Traits in Common Wheat

open access: yesPlant Biotechnology Journal, Volume 24, Issue 11, Page 5911-5926, November 2026.
ABSTRACT The metabolome is highly diverse and the closest layer to phenotype; therefore, it is commonly regarded as a bridge between the genome and phenome in plants. Here, we performed large‐scale metabolome analysis using liquid chromatography–tandem mass spectrometry (LC–MS/MS) and 33 grain‐related traits in a diverse panel of natural accessions and
Guoguo Lv   +11 more
wiley   +1 more source

ALDH Inhibition‐Primed Photocatalysis Disrupts Cancer Stemness Plasticity

open access: yesAngewandte Chemie, Volume 138, Issue 43, 19 October 2026.
DE‐Et converts ALDH‐mediated redox buffering into a photoredox vulnerability by coupling ALDH inhibition with red‐light‐driven catalytic NADH oxidation. This enzyme‐coupled photoredox strategy sustains mitochondrial NADH/NAD+ imbalance, induces pyroptotic tumor cell death, suppresses tumor growth in vivo, and promotes systemic antitumor immunity ...
Yujin Kim   +10 more
wiley   +2 more sources

Spatiotemporal Dynamics of Cytosolic NADPH in Living Arabidopsis thaliana

open access: yesPlant, Cell &Environment, Volume 49, Issue 11, Page 9101-9116, November 2026.
ABSTRACT In plants, an adequate supply of Nicotinamide adenine dinucleotide phosphate (NADPH) in the cytosol is crucial for maintaining a variety of biosynthetic and antioxidant reactions. Cytosolic NADPH is mainly generated via four enzymatic pathways: NADP‐dependent malic dehydrogenase (NADP‐ME), cytosolic oxidative pentose phosphate pathway (cOPPP),
Danying Lu   +4 more
wiley   +1 more source

Investigation of the DSF/Cu Reaction Using HR LCMS and Reactivity Studies

open access: yesChemBioChem, Volume 27, Issue 20, 28 October 2026.
The generation of Cu(II)bis(diethyldithiocarbamate) from the combination of disulfiram and Cu salts, as used in many cuprototic cancer studies, is examined using high‐resolution liquid chromatography‐mass spectroscopy. By monitoring the reaction at different sampling times to determine reaction intermediates and the addition of adduct‐forming traps, a ...
Jordan Lyons, Patrick J. Farmer
wiley   +1 more source

Design Considerations for Polymer–Deep Eutectic Solvent Hybrid Systems for Transdermal Drug Delivery

open access: yesJournal of Applied Polymer Science, Volume 143, Issue 40, October 20, 2026.
Deep eutectic solvents (DESs) act as tunable, green excipients that modulate polymer structure–property relationships to enhance drug solubility, skin permeation, stability, and controlled release. Through hydrogen‐bond interactions, DES–polymer hybrid systems enable improved transdermal performance, offering a rational, design‐driven platform for ...
Madhavi Kailas Kapale   +3 more
wiley   +1 more source

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