Results 191 to 200 of about 329,736 (281)

Design, Synthesis, and Protective Effect Evaluation on Myocardial Ischemia of New Triazole Aldehyde Dehydrogenase 2 Activators. [PDF]

ACS Med Chem Lett
Zhao F, Pan X, Chen X, Yu Z, Tian W, Guo J, Sun X, Zhou R, Fang S, Chen Y, Wang J, Zheng C.   +11 more
europepmc   +1 more source

Targeted Mutagenesis Reveals Noncanonical Genetic Requirements for Carbon Monoxide Oxidation

Environmental Microbiology, Volume 28, Issue 11, November 2026.
Using targeted mutagenesis, this study shows that form II CODH does not contribute to CO oxidation in the model carboxydovore Paraburkholderia terrae COX and reveals that canonical maturation pathways are not universally conserved. These findings refine genome‐based predictions of microbial metabolism and improve understanding of metalloenzyme assembly
R. A. Dawson, M. Hernández
wiley   +1 more source

Aldehyde dehydrogenase 1 A1 regulates the transcription of PD-L1 and its targeting with disulfiram together with PD-L1 immunotherapy synergistically delays cyst growth in ADPKD. [PDF]

Kidney Int
Cheng AS, Li LX, Zhou JX, Harris PC, Calvet JP, Li X.   +5 more
europepmc   +1 more source

Multiomics Reveals a Production Signature Resembling Mammalian Metabolic Ageing and That Dietary Spermidine Enhances Lipid Handling in Farmed Salmon

Aging Cell, Volume 25, Issue 11, November 2026.
Lipidomic and proteomic profiling of fat and skeletal muscle from farmed Atlantic salmon at different production stages revealed a signature resembling mammalian metabolic ageing at the seawater stage. This included lipid remodelling, a reduction in markers of substrate handling for ATP production, decreased abundance of autophagy–lysosomal and ...
Kanchan Phadwal, Dominic Kurian, Jennifer Haggarty, Herve Migaud, Viktoriya Nicheva, James Dick, Muhammad Khalid F. Salamat, Phillip D. Whitfield, Chessor Matthew, Nicholas M. Wade, Mónica B. Betancor, Daniel J. Macqueen   +11 more
wiley   +1 more source

Design, Synthesis, and Study of Protective Activity Against Stroke for Novel Water-Soluble Aldehyde Dehydrogenase 2 Activators. [PDF]

Molecules
Zhao F, Yu Z, Tian W, Huang X, Zhang Q, Zhou R, Hu J, Yu S, Chen X, Zheng C.   +9 more
europepmc   +1 more source

GABAergic Network Dysregulation in Alcohol Use Disorder: Receptor–Transporter Interactions Driving the Transition From Goal‐Directed to Compulsive Behaviour

Addiction Biology, Volume 31, Issue 11, November 2026.
Astrocytic GAT3 regulates ambient GABA levels in the globus pallidus externus (GPe). Reduced GAT3 function enhances extrasynaptic GABAergic signalling and disrupts subthalamic nucleus (STN) regulation and cortical signal fidelity.ABSTRACTAlcohol use disorder (AUD) is characterized by a shift from controlled, goal‐directed drinking to compulsive ...
Hannah Aranda, Nathan Jones, Humza Haroon, Doo‐Sup Choi   +3 more
wiley   +1 more source

Identification of Mustard Aldehyde Dehydrogenase (ALDH) Gene Family and Expression Analysis Under Salt and Drought Stress. [PDF]

Genes (Basel)
Zheng Y, Wang S, He L, Chen R, Zhang W, He H, Hu H, Liu X, Wan H, Wu C.   +9 more
europepmc   +1 more source

Genomic variation drives plant flavor diversification

Journal of Integrative Plant Biology, Volume 68, Issue 11, Page 3895-3913, November 2026.
This review explains how genomic variation shapes plant flavor by altering the biosynthetic and regulatory pathways of key attributes like sweetness, acidity, bitterness, piquancy, astringency, and aroma. It also discusses how multi‐omics, AI‐assisted breeding, and gene editing can translate this knowledge into plants with improved flavor, nutrition ...
Huimin Hu, Yanwei Hao, Yiwei Zhou, Xia Zhang, Rui Xia, Pan Liao   +5 more
wiley   +1 more source

Aldehyde Dehydrogenase 2 Gene Mutation May Reduce the Risk of Rupture of Intracranial Aneurysm in Chinese Han Population. [PDF]

J Stroke
Chen X, Gui S, Wei D, Deng D, Tang Y, Lv J, You W, Jiang J, Lin J, Ge H, Liu P, Jiang Y, Ma L, Wang Y, Lv M, Li Y.   +15 more
europepmc   +1 more source