Construction of Recombinant Saccharomyces cerevisiae with Ethanol and Aldehydes Tolerance via Overexpression of Aldehyde Reductase [PDF]
Microorganisms, 2022 Furfural and hydroxy-methyl-furfural (HMF) are produced by lignocellulosic biomass during heat or acid pretreatment and are toxic to yeast. Aldehyde reductase is the main enzyme to reduce furfural and HMF.
Nileema R. Divate +3 more
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Pleiotropic Actions of Aldehyde Reductase (AKR1A) [PDF]
Metabolites, 2021 We provide an overview of the physiological roles of aldehyde reductase (AKR1A) and also discuss the functions of aldose reductase (AKR1B) and other family members when necessary.
Junichi Fujii +3 more
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Tolerance to Glutaraldehyde in Escherichia coli Mediated by Overexpression of the Aldehyde Reductase YqhD by YqhC [PDF]
Frontiers in Microbiology, 2021 Glutaraldehyde is a widely used biocide on the market for about 50 years. Despite its broad application, several reports on the emergence of bacterial resistance, and occasional outbreaks caused by poorly disinfection, there is a gap of knowledge on the ...
Beatriz Merchel Piovesan Pereira +7 more
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Rhodanine-3-acetamide derivatives as aldose and aldehyde reductase inhibitors to treat diabetic complications: synthesis, biological evaluation, molecular docking and simulation studies [PDF]
BMC Chemistry, 2021 In diabetes, increased accumulation of sorbitol has been associated with diabetic complications through polyol pathway. Aldose reductase (AR) is one of the key factors involved in reduction of glucose to sorbitol, thereby its inhibition is important for ...
Mohsinul Mulk Bacha +8 more
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Isobutyraldehyde production from
Microbial Cell Factories, 2012 Background Increasing global demand and reliance on petroleum-derived chemicals will necessitate alternative sources for chemical feedstocks. Currently, 99% of chemical feedstocks are derived from petroleum and natural gas.
Rodriguez Gabriel M, Atsumi Shota
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Dealing with aflatoxin B1 dihydrodiol acute effects: Impact of aflatoxin B1-aldehyde reductase enzyme activity in poultry species tolerant to AFB1 toxic effects. [PDF]
PLoS ONE, 2020 Aflatoxin B1 aldehyde reductase (AFAR) enzyme activity has been associated to a higher resistance to the aflatoxin B1 (AFB1) toxicity in ethoxyquin-fed rats.
Hansen Murcia, Gonzalo J Diaz
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Crystal structures and kinetic studies of a laboratory evolved aldehyde reductase explain the dramatic shift of its new substrate specificity [PDF]
IUCrJ, 2023 The Fe2+-dependent E. coli enzyme FucO catalyzes the reversible interconversion of short-chain (S)-lactaldehyde and (S)-1,2-propanediol, using NADH and NAD+ as cofactors, respectively.
Shruthi Sridhar +8 more
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Structural and Biochemical Analysis of the Furan Aldehyde Reductase YugJ from Bacillus subtilis. [PDF]
Int J Mol Sci, 2022 NAD(H)/NADP(H)-dependent aldehyde/alcohol oxidoreductase (AAOR) participates in a wide range of physiologically important cellular processes by reducing aldehydes or oxidizing alcohols.
Cho HY +4 more
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Frontiers in Bioengineering and Biotechnology, 2020 Aldehydes are a class of highly versatile chemicals that can undergo a wide range of chemical reactions and are in high demand as starting materials for chemical manufacturing.
Jee Loon Foo +10 more
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Unraveling the metabolic potential and roles of reductases in the omicsynin biosynthetic gene cluster [PDF]
Natural Products and BioprospectingOmicsynins are a group of pseudo-tetrapeptides produced by Streptomyces sp. 1647, which exhibited potent anti-influenza A virus and anti-coronavirus activities. However, its biosynthesis mechanism of C-terminus reduction remains unknown. In this work, we
Yihong Li +8 more
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