Results 31 to 40 of about 46,498 (194)

Identification and Application of a Novel Patulin Degrading Enzyme From Meyerozyma guilliermondii

Advanced Science, EarlyView.
Patulin (PAT), a hazardous mycotoxin, threatens human health. A novel yeast‐derived short‐chain dehydrogenase/reductase effectively degrades PAT into nontoxic ascladiol via catalytic triad activity. The biological detoxification process has no significant effect on the quality of fresh pear juice.
Yu Zhang, Qianhua Zhao, Solairaj Dhanasekaran, Esa Abiso Godana, Yue Zhang, Xue Bai, Qiya Yang, Hongyin Zhang   +7 more
wiley   +1 more source

Integrated stress response of Escherichia coli to methylglyoxal : transcriptional readthrough from the nemRA operon enhances protection through increased expression of glyoxalase I [PDF]

, 2013
© 2013 The Authors.
Booth, Ian R, de Almeida, Camila, de Moura, Alessandro P S, Miller, Samantha, Ozyamak, Ertan   +4 more
core   +1 more source

Pig muscle aldehyde reductase. Identity of pig muscle aldehyde reductase with pig lens aldose reductase and with the low Km aldehyde reductase of pig brain and pig kidney.

Journal of Biological Chemistry, 1983
A monomeric (Mr = 43,000) NADPH-dependent oxidoreductase with a broad substrate specificity for aliphatic and aromatic aldehydes and aldo sugars has been purified from the skeletal muscle of female and castrated pigs. The properties of this enzyme are consistent with those of aldose reductase (EC 1.1.1.21), and the enzyme is immunologically identical ...
T G Flynn, J A Cromlish
openaire   +3 more sources

Cytochrome P450associated with insecticide resistance catalyzes cuticular hydrocarbon production in Anopheles gambiae. [PDF]

, 2016
The role of cuticle changes in insecticide resistance in the major malaria vector Anopheles gambiae was assessed. The rate of internalization of 14C deltamethrin was significantly slower in a resistant strain than in a susceptible strain.
Anthousi, Amalia, Antoine, Sanou, Balabanidou, Vasileia, Blomquist, Gary J., Chalepakis, George, Hemingway, Janet, Juarez, Marta Patricia, Kampouraki, Anastasia, Lycett, Gareth J., Lynd, Amy, Mac Lean, Marina, Mijailovsky, Sergio Javier, Ranson, Hilary, Tittiger, Claus, Vontas, John   +14 more
core   +3 more sources

Aldehyde‐forming fatty acyl‐ C o A reductase from cyanobacteria: expression, purification and characterization of the recombinant enzyme [PDF]

, 2013
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/101857/1/febs12443 ...
Das, Debasis, Lin, Fengming, Lin, Xiaoxia N., Marsh, E. Neil G.   +3 more
core   +1 more source

Mixing and Matching of Hybrid Megasynthases is a Hub for the Evolution of Metabolic Diversity in Cyanobacteria

Angewandte Chemie International Edition, EarlyView.
Natural combinatorics: Evolutionary mixing and matching of three cyanobacterial biosynthetic gene clusters resulted in the emergence of minutumamides, a novel family of peptide‐polyketide hybrids. Retro‐evolutionary analysis led to the discovery of nostopeptolide KVJ3, an evolutionary ancestor that links nostopeptolide and minutumamide biosynthesis and
Keishi Ishida, Qi Sun, Jonna Teikari, Christian Hertweck, Elke Dittmann, Masahiro Murakami, Martin Baunach   +6 more
wiley   +1 more source

Thiotemplated Polyketide Chain Fusion and Reductive Cyclization Build the Reactive Butenolide Core of Malleicyprol

Angewandte Chemie International Edition, Accepted Article.
Malleicyprol, a virulence factor of notorious animal and human pathogens of the Burkholderia pseudomallei (BP) group, features a molecular cyclopropanol warhead linked to a reactive butenolide core. Biosynthetic considerations suggested that this heterocycle was formed by the merger of two individual polyketide chains, but the precise mechanism has ...
Jonas Fiedler, Leo Dumjahn, Ishida-Ito Mie, Felix Trottmann, Keishi Ishida, Christian Hertweck   +5 more
wiley   +1 more source

Novel Sulfonylhydrazones With Sulfonate Ester Framework: Promising Dual Inhibitors of AChE and hCAs

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative disorder that affects millions of individuals worldwide. Treatment strategies for AD vary depending on cognitive and behavioral symptoms, with cholinergic replacement therapy using acetylcholinesterase (AChE) inhibitors being one of the primary approaches.
Cansu Öztürk, Neslihan Balci, Osman Nuri Aslan, Erbay Kalay   +3 more
wiley   +1 more source

Purine Chemistry in the Early RNA World at the Origins of Life: From RNA and Nucleobases Lesions to Current Key Metabolic Routes

ChemBioChem, EarlyView.
In the nascent processes of the beginnings and evolution of life, nucleobases and especially purines, ribonucleos(t)ides and primitive RNAs have been continuously modified. A RNA‐peptide world and key metabolic pathways probably have emerged from the corresponding chemical modifications resulting from adenine deamination, purine alkylation and ...
Jean‐Luc Décout, Marie‐Christine Maurel   +1 more
wiley   +1 more source

Synthesis of Simplified Azasordarin Analogs as Potential Antifungal Agents [PDF]

, 2019
A new series of simplified azasordarin analogs was synthesized using as key steps a Diels–Alder reaction to generate a highly substituted bicyclo[2.2.1]heptane core, followed by a subsequent nitrile alkylation.
Dockendorff, Chris, Wu, Yibiao
core   +4 more sources