Results 61 to 70 of about 186,754 (233)

Inactivation of carbonyl reductase from human brain by phenylglyoxal and 2,3-butanedione: a comparison with aldehyde reductase and aldose reductase.

, 1987
Aldehyde reductase (alcohol:NADP+ oxidoreductase, EC 1.1.1.2), aldose reductase (alditol:NAD(P)+ 1-oxidoreductase, EC 1.1.1.21) and carbonyl reductase (secondary-alcohol:NADP+ oxidoreductase, EC 1.1.1.184) constitute the enzyme family of the aldo-keto ...
Wermuth B, Bohren KM, von Wartburg JP
core   +1 more source

Metabolic Engineering of Saccharomyces cerevisiae for Enhanced Dihydroartemisinic Acid Production

Frontiers in Bioengineering and Biotechnology, 2020
Direct bioproduction of DHAA (dihydroartemisinic acid) rather than AA (artemisinic acid), as suggested by previous work would decrease the cost of semi-biosynthesis artemisinin by eliminating the step of initial hydrogenation of AA.
Bo-Xuan Zeng, Bo-Xuan Zeng, Ming-Dong Yao, Ming-Dong Yao, Ying Wang, Ying Wang, Wen-Hai Xiao, Wen-Hai Xiao, Ying-Jin Yuan, Ying-Jin Yuan   +9 more
doaj   +1 more source

Investigation of the arylnitroso reductase activity of pig liver aldehyde reductase [PDF]

Biochemical Journal, 1986
The reduction of p-nitroso-N-dimethylaniline, p-nitroso-N-diethylaniline, p-nitrosophenol and p-nitroso-N-phenylaniline with NADPH in the presence of aldehyde reductases 1 and 2 is described. The reactivity of these nitroso substrates is increased by hydrophobic substituents and those promoting OH- elimination from the molecule of the reduced substrate.
J, Kovár, J, Plocek
openaire   +2 more sources

Nicotiana benthamiana as a Production Platform for Artemisinin Precursors [PDF]

, 2010
Background Production of pharmaceuticals in plants provides an alternative for chemical synthesis, fermentation or natural sources. Nicotiana benthamiana is deployed at commercial scale for production of therapeutic proteins.
Herpen, T.W.J.M., van, Nogueira, M., Teun W J M van Herpen, van Herpen Teun W. J. M., Harro J. Bouwmeester, Cankar, Katarina, Katarina Cankar, Harpen, Teun W. J. M. van, Marilise Nogueira, Dirk Bosch, Harro J Bouwmeester, Bouwmeester Harro J., Beekwilder, Jules, Jules Beekwilder, Teun W. J. M. van Herpen, Nogueira Marilise, Cankar, K., van Herpen, T.W.J.M., Cankar Katarina, Beekwilder Jules, Bouwmeester, Harro, Nogueira, Marilise, Bosch, H.J., Bosch Dirk, Bouwmeester, H.J., Beekwilder, M.J., Bosch, Dirk   +26 more
core   +1 more source

Synthesis and Activity‐Based Protein Profiling Identifies Aldo‐Keto Reductase 1C3 as Target Protein of Myxoglucamides

Angewandte Chemie International Edition, EarlyView.
Myxoglucamide A—a novel glycolipopeptide isolated from myxobacteria—was synthesized, and activity‐based protein profiling identified aldo‐keto reductase 1C3 (AKR1C3) as its main target in human cells. Structure‐activity relationship studies, together with biophysical characterization and X‐ray crystallography, elucidated the structural basis of AKR1C3 ...
Thomas Siemon, Vivek K. Mishra, Mingming Zhao, Konrad Büssow, Alexander Popoff, Chengzhang Fu, Rolf Müller, Lothar Jänsch, Wulf Blankenfeldt, Mark Brönstrup   +9 more
wiley   +1 more source

Preussia sp. BSL-10 producing nitric oxide, gibberellins, and indole acetic acid and improving rice plant growth

Journal of Plant Interactions, 2018
Preussia sp. have been least known to improve plant growth and produce phytohormones. The current study investigated the production of nitric oxide (NO), indole-3-acetic acid (IAA), and gibberellins (GA4, GA7, GA15, and GA53) by a novel endophytic-fungal
Khdija Al-Hosni, Raheem Shahzad, Abdul Latif Khan, Qari Muhammad Imran, Ahmed Al Harrasi, Ahmed Al Rawahi, Sajjad Asaf, Sang-Mo Kang, Byung-Wook Yun, In-Jung Lee   +9 more
doaj   +1 more source

Development and exploration of novel substituted thiosemicarbazones as inhibitors of aldose reductase via in vitro analysis and computational study

Scientific Reports, 2022
The role of aldose reductase (ALR2) in causing diabetic complications is well-studied, with overactivity of ALR2 in the hyperglycemic state leading to an accumulation of intracellular sorbitol, depletion of cytoplasmic NADPH and oxidative stress and ...
Aqeel Imran, Muhammad Tariq Shehzad, Syed Jawad Ali Shah, Taha al Adhami, Mark Laws, Khondaker Miraz Rahman, Rima D. Alharthy, Imtiaz Ali Khan, Zahid Shafiq, Jamshed Iqbal   +9 more
doaj   +1 more source

Inhibition of aldehyde reductase I by some isoquinoline alkaloids

, 1987
Aldehyde reductase I has been found to be inhibited by certain isoquinoline alkaloids (protoberberines, protopines, benzylisoquinolines, benzyltetrahydroisoquinolines, phthalideisoquinolines, pavinanes) and narceine imide.
Hana Paulová, Jan Kovář, Jiří Slavík, Jiří Plocek   +3 more
core   +1 more source

Synergistic Advanced Oxidation and Physicochemical Treatment Strategies for Antibiotic Removal and Resistance Mitigation in Water

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT The presence of antibiotics in water not only causes environmental pollution but also increases the growth of antibiotic‐resistant bacterial genes, which pose serious threats to human beings and other water residents. Large numbers of people are reportedly affected by the resistant bacterial genes, as many broad‐spectrum antibiotics are not ...
Amir Zada, Shohreh Azizi
wiley   +1 more source

Recent advances in the improvement of cyanobacterial enzymes for bioalkane production

Microbial Cell Factories, 2022
The use of biologically produced alkanes has attracted considerable attention as an alternative energy source to petroleum. In 2010, the alkane synthesis pathway in cyanobacteria was found to include two small globular proteins, acyl-(acyl carrier ...
Yuuki Hayashi, Munehito Arai
doaj   +1 more source