Results 211 to 220 of about 428,832 (350)

Oxidative stress and human spermatozoa: diagnostic and functional significance of aldehydes generated as a result of lipid peroxidation.

open access: yesMolecular human reproduction, 2015
R. Moazamian   +6 more
semanticscholar   +1 more source

Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis

open access: yesAngewandte Chemie, EarlyView.
Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley   +2 more sources

Nickel‐Catalyzed Enantioconvergent Arylation of Unactivated Cyclic Electrophiles: Asymmetric Synthesis of 3‐Substituted Pyrrolidines

open access: yesAngewandte Chemie, EarlyView.
Metal‐catalyzed enantioconvergent substitutions of unactivated cyclic electrophiles by organometallic nucleophiles have not previously been reported. Herein, a chiral nickel catalyst is described that achieves this objective, coupling 3‐iodopyrrolidine derivatives with arylzinc nucleophiles.
Ting Hei Matthew Wong   +2 more
wiley   +2 more sources

Diazo Transfer From Nitrous Oxide Employing Phosphorus Ylides

open access: yesAngewandte Chemie, EarlyView.
A phosphorus ylide‐mediated strategy achieves the direct fixation of nitrous oxide (N2O) to access diazo compounds, which after intra‐ or intermolecular trapping, afford N2‐containing organic building blocks. This approach provides an alternative to hazardous diazo‐transfer reagents and establishes N2O fixation as a sustainable methodology.
Jhen‐Kuei Yu   +4 more
wiley   +2 more sources

Direct Acylation of Alkyl and Aryl Bromides via Nickel-Catalyzed Aldehyde C-H Functionalization. [PDF]

open access: yesJ Org Chem
Calvert SJ   +6 more
europepmc   +1 more source

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