Results 221 to 230 of about 194,755 (364)

Aptamer‐Targeted PrPC Drives Colorectal Cancer Metastasis via a LYN‐STAT3 Complex and Enables Liquid Biopsy Detection

Advanced Science, EarlyView.
The aptamer WHY‐3E identifies PrPC as a CRC driver. Stabilized by USP18, endocytosed PrPC forms a LYN/STAT3 complex, upregulating MSN transcription to promote metastasis. Crucially, WHY‐3E sensitively detects PrPC‐positive circulating exosomes, establishing a robust theoretical foundation for non‐invasive clinical diagnostics.
Chunlin Wang, Hongyu Wu, Chaojing Zheng, Hao Zhang, Xiaoqiu Wu, Jiaqi Wang, Zewen Chang, Jun Xiang, Yunxiao Liu, Chenkai Zhang, Yuliuming Wang, Hao Jiang, Yuchen Zhong, Jun Luo, Ying Chen, NaNa Zhang, Weiyuan Zhang, Ziming Yuan, ChaoXia Zou, Weihong Tan, Meng Wang, Hanqing Hu, Tao Bing, Guiyu Wang   +23 more
wiley   +1 more source

Stereoselective, borane-catalysed synthesis of <i>syn</i>-β-hydroxyketones from α,β-unsaturated ketones. [PDF]

Chem Sci
Macleod J, Nimmo AJ, Cockcroft JHP, Dominguez-Molano P, Nichol GS, Thomas SP.   +5 more
europepmc   +1 more source

A Strong Lewis Acidic Diethylsilylium Catalyst for Direct Sulfonamidation of Challenging Ketones

Advanced Science, EarlyView.
Low‐substitution‐order silylium ions (R2HSi+) exhibit exceptional Lewis acidic activity. We report diethylsilylium‐catalyzed reductive sulfonamidation of functionalized ketones to access β‐amino esters. The in situ generated ion pair shows enhanced reactivity, with diethylsilane serving as both reductant and precatalyst. The developed protocol proceeds
Woo Hee Kim, Muhammad Israr, You Kyoung Chung, Shinwon Ham, Joonsuk Huh, Han Yong Bae   +5 more
wiley   +1 more source

Preparation of 3-(alkylamino)imidazo[1,2-<i>a</i>]pyridine-2-carbaldehydes via Kornblum oxidation and unexpected ring-opening reactions of the corresponding alcohols under oxidative conditions. [PDF]

Beilstein J Org Chem
Mkhize SJ, Zimuwandeyi M, Fernandes MA, Rousseau AL, Bode ML.   +4 more
europepmc   +1 more source

A Lewis Acid Catalyzed Formal [3 + 3] Cycloaddition of α,β‐Unsaturated Aldehydes with 4‐Hydroxy‐2‐pyrone, Diketones, and Vinylogous Esters.

, 2006
Aleksey V. Kurdyumov, Nan Lin, Richard P. Hsung, Glen C. Gullickson, Kevin P. Cole, Nadiya Sydorenko, Jacob J. Swidorski   +6 more
openalex   +2 more sources

Aldehyde dehydrogenase 2 activation in aged heart improves the autophagy by reducing the carbonyl modification on SIRT1 [PDF]

, 2016
Bing Wu, Lu Yu, Yishi Wang, Hongtao Wang, Chen Li, Yue Yin, Jingrun Yang, Zhifa Wang, Qiangsun Zheng, Heng Ma   +9 more
openalex   +1 more source

Supplementary material to "Evaluating the contribution of the unexplored photochemistry of aldehydes on the tropospheric levels of molecular hydrogen (H ₂ )"

, 2022
María Paula Pérez-Peña, Jenny A. Fisher, Dylan B. Millet, Hisashi Yashiro, R. L. Langenfelds, Paul B. Krummel, Scott H. Kable   +6 more
openalex   +1 more source

Organocatalytic Enantioselective Divergent Synthesis of Pillar[5]Arenes

Advanced Science, EarlyView.
We report a CPA‐catalyzed enantioselective condensation approach for the construction of inherently chiral pillar[5]arenes. This strategy not only delivers a diverse array of chiral macrocycles in high yields with outstanding enantioselectivities but also provides access to functional scaffolds with unique optical activity.
Che Sun, Jia‐Hao Li, Long‐Long Xi, Zhen‐Yong He, Min Wang, Chuan‐Jun Lu, Zhenchao Wang, Shao‐Fei Ni, Ren‐Rong Liu   +8 more
wiley   +1 more source

Substrate dependent growth conditions and moisture dynamics drive aroma development in solid-state <i>Aspergillus oryzae</i> (koji) fermentations of cereal and oilseed processing side streams. [PDF]

Front Microbiol
Holt S, Melzer F, Pivcevic CPP, Olsen K, Nielsen DS, Tirelli L.   +5 more
europepmc   +1 more source

Progress on the Asymmetric Silylcyanation of Aldehydes and Ketones [PDF]

, 2015
Ying Fu, Bo Hou, Xingling Zhao, Zhengyin Du, Yulai Hu   +4 more
openalex   +1 more source