Results 21 to 30 of about 2,516,365 (158)

In Vitro Cytotoxic Activity of Coleus hadiensis Methanolic Extract: Metabolic and Transcriptomic Effects in Lung Cancer Cell Line [PDF]

Molecules
Cancer cells resort to metabolic reprogramming to sustain proliferation. Lung cancer has one of the highest mortality rates of all types of cancer. An important factor in its high mortality rate is its tumors’ ability to undergo significant metabolic ...
Ana L. Valdez-Arellanes, Mónica A. Ramírez-Cabrera, Eder U. Arredondo-Espinoza, Emanuel Hernández-Núñez, Monica N. Sanchez-González, Isaias Balderas-Rentería, Karla Ramirez-Estrada   +6 more
doaj   +2 more sources

An integrative bioinformatic and Mendelian randomization study exploring the role of polyunsaturated fatty acid metabolism in laryngeal cancer [PDF]

Discover Oncology
Objective This study aimed to explore potential associations between polyunsaturated fatty acid (PUFA) metabolism and laryngeal cancer (LC) using a combination of Mendelian randomization (MR) and integrative bioinformatics, while investigating its ...
Lina Peng, Haibin Ma, Longchao Qin, Qian Zhao, Xueyan Ren, Zihao Wang, Jing Hu, Haiping Han   +7 more
doaj   +2 more sources

Integrative Analysis of Transcriptomics and Metabolomics Reveals the Effects of Western-Style Diets on Spleen Function [PDF]

Biology
The spleen is essential for immunity, mediating host defense against pathogens and regulating immunological homeostasis. Western-style diets commonly cause the aggregation of body fat and the emergence of obesity.
Shengguo Tang, Dongfang Li, Yanna Ma, Zhiying Zhao, Liangyuan Peng, Shuchao Liao, Haiming Ma, Hongjiang Wei   +7 more
doaj   +2 more sources

First patient in Serbia with biochemically and genetically diagnosed pyridoxine-dependent epilepsy [PDF]

Vojnosanitetski Pregled, 2017
Introduction. Pyridoxine-dependent epilepsy (PDE) is a rare autosomal recessive inborn error of metabolism present with early-onset seizures resistant to common anticonvulsants.
Ješić Miloš M., Ješić Maja D., Buljugić Svetlana, Živanović Aleksandra   +3 more
doaj   +1 more source

Global Metabolomics Discovers Two Novel Biomarkers in Pyridoxine-Dependent Epilepsy Caused by ALDH7A1 Deficiency [PDF]

, 2022
Pyridoxine-dependent epilepsy (PDE) is a rare autosomal recessive developmental and epileptic encephalopathy caused by pathogenic variants in the ALDH7A1 gene (PDE-ALDH7A1), which mainly has its onset in neonates and infants.
Hans-Otto Böhm, Kristensen, Erle, Østeby Vassli, Anja, Böhm, Hans-Otto, Rootwelt, Helge, Mazyar Yazdani, Hanne Bendiksen Skogvold, Helge Rootwelt, Brodtkorb, Eylert, Elgstøen, Katja Benedikte Prestø, Mørk Sandås, Elise, Skogvold, Hanne Bendiksen, Elise Mørk Sandås, Sandås, Elise Mørk, Elgstøen, Katja B. Prestø, Eylert Brodtkorb, Anja Østeby Vassli, Katja Benedikte Prestø Elgstøen, Yazdani, Mazyar, Erle Kristensen   +19 more
core   +1 more source

ALDH7A1 rs12514417 polymorphism may increase ischemic stroke risk in alcohol-exposed individuals

Nutrition & Metabolism, 2022
Background: Epidemiological studies have identified common risk factors for cerebral stroke worldwide. Some of these factors include hypertension, diabetes, smoking, excessive drinking, and dyslipidemia.
Chun-Hsiang Lin, Oswald Ndi Nfor, Chien-Chang Ho, Shu-Yi Hsu, Disline Manli Tantoh, Yi-Chia Liaw, Daria Mochly-Rosen, Che-Hong Chen, Yung-Po Liaw   +8 more
doaj   +1 more source

Genotypic and phenotypic spectrum of pyridoxine-dependent epilepsy (ALDH7A1 deficiency) [PDF]

, 2010
Pyridoxine-dependent epilepsy was recently shown to be due to mutations in the ALDH7A1 gene, which encodes antiquitin, an enzyme that catalyses the nicotinamide adenine dinucleotide-dependent dehydrogenation of L-{alpha}-aminoadipic semialdehyde/L-{Delta}
Hemingway, Cheryl, François Feillet, Pascale De Lonlay, Sarah Aylett, Struys, E A, Dulac, Olivier, Schmitt, Bernhard, Bernhard Schmitt, Jakobs, C, Rennie, J, Marlow, N., Hughes, M. I., De Lonlay, Pascale, Pike, M G, Mills, P B, Dulac, O, Feillet, François, Zuberi, S. M., Eduard A. Struys, Mills, Kevin A, William J. Craigen, Christensen, Ernst, Schmitt, B, De Lonlay, P, Footitt, E. J., Janet Rennie, Christensen, E., Emma J. Footitt, Tuschl, Karin, Struys, E. A., Hemingway, C., Mills, P.B., Marlow, N, Baxter, P, Footitt, E.J., Hughes, M Imelda, Aylett, S, De Lonlay, P., Rennie, Janet, Mills, K.A., Sameer M. Zuberi, Mills, K A, Struys, Eduard A, Lonlay, P. de, Tuschl, K, Varadkar, S, Rima Nabbout, Karin Tuschl, Aylett, Sarah, Clayton, P. T., Varadkar, Sophia, Philippa B. Mills, Footitt, E J, Zuberi, S M, Ernst Christensen, Aylett, S., Peter Baxter, Clayton, Peter T, Zuberi, S.M., Neil Marlow, Peter T. Clayton, M. Imelda Hughes, Jakobs, Cornelis, Pike, M.G., Tuschl, K., Hughes, M.I., Schmitt, B., Baxter, P., Clayton, P T, Sophia Varadkar, Struijs, E.A., Craigen, W J, Footitt, Emma J, Feillet, F., Cheryl Hemingway, Hughes, M I, Craigen, W.J., Dulac, O., Nabbout, Rima, Pike, M. G., Mike G. Pike, Feillet, F, Pike, Mike G, Rennie, J., Mills, P. B., Christensen, E, Marlow, Neil, Kevin A. Mills, Olivier Dulac, Zuberi, Sameer M, Craigen, William J, Nabbout, R, Mills, K. A., Varadkar, S., Baxter, Peter, Mills, Philippa B, Nabbout, R., Clayton, P.T., Jakobs, C., Hemingway, C, Cornelis Jakobs, Craigen, W. J.   +101 more
core   +1 more source

A glycolysis-based three-gene signature predicts survival in patients with lung squamous cell carcinoma

BMC Cancer, 2021
Background Lung cancer is one of the most lethal and most prevalent malignant tumors worldwide, and lung squamous cell carcinoma (LUSC) is one of the major histological subtypes.
Guichuan Huang, Jing Zhang, Ling Gong, Yi Huang, Daishun Liu   +4 more
doaj   +1 more source

A Comparison of RNA Interference via Injection and Feeding in Honey Bees

Insects, 2022
RNA interference (RNAi) has been used successfully to reduce target gene expression and induce specific phenotypes in several species. It has proved useful as a tool to investigate gene function and has the potential to manage pest populations and reduce
Yong Zhang, Zhen Li, Zi-Long Wang, Li-Zhen Zhang, Zhi-Jiang Zeng   +4 more
doaj   +1 more source

Intragenic deletions of ALDH7A1 in pyridoxine-dependent epilepsy caused by Alu-Alu recombination [PDF]

, 2015
OBJECTIVE To investigate the role of intragenic deletions of ALDH7A1 in patients with clinical and biochemical evidence of pyridoxine-dependent epilepsy but only a single identifiable mutation in ALDH7A1.
Mills, Philippa B, Zemel, Matthew, Cook, Joseph, Gospe, Sidney M, Mefford, Heather C, Geraghty, Eileen, Clayton, Peter T, Nordli, Douglas R, Paul, Karl, Plecko, Barbara   +9 more
core   +1 more source