Results 141 to 150 of about 21,208,579 (315)

Effect of hyperbaric oxygenation on carbohydrate metabolism protein synthesis in the myocardium during sustained hypodynamia [PDF]

Glycolysis and the intensity of protein synthesis were studied in 140 white male rats in subcellular fractions of the myocardium during 45 day hypodynamia and hyperbaric oxygenation.
Makarov, G. A.
core   +1 more source

Clathrins Are Involved in the Endocytosis of Host Cytosol in the Malaria Parasite

Traffic, Volume 27, Issue 1, March 2026.
This study characterized clathrin function in hemoglobin uptake from host red blood cells via the malaria parasite's specific endocytosis machinery, cytostome. Clathrin heavy chain, clathrin light chain, and AP‐1 γ subunit were found associated with certain proteins known to be involved in cytostome function, and they were localized at the collars of ...
Jun Miao, Amuza Byaruhanga Lucky, Gang Ning, Xian Xia, Xiaoying Liang, Faiza Siddiqui, Hui Min, Chengqi Wang, Xiaolian Li, Z. Hong Zhou, Liwang Cui   +10 more
wiley   +1 more source

Uncovering the Key Factors Influencing Phytochemical and Phytopharmacological Properties During Medicinal Plant Processing

eFood, Volume 7, Issue 1, February 2026.
From farm to pharma, this review details the engineering of quality in medicinal plants through a science‐driven approach: it first elucidates how genetic and environmental factors inscribe the plant's phytochemical and phytopharmacological profile before harvest, and then dissects the postharvest techniques and technologies—chemical and thermal pre ...
Elyas Aryakia
wiley   +1 more source

Aldolase A accelerates hepatocarcinogenesis by refactoring c-Jun transcription

Journal of Pharmaceutical Analysis
Hepatocellular carcinoma (HCC) expresses abundant glycolytic enzymes and displays comprehensive glucose metabolism reprogramming. Aldolase A (ALDOA) plays a prominent role in glycolysis; however, little is known about its role in HCC development.
Xin Yang, Guang-Yuan Ma, Xiao-Qiang Li, Na Tang, Yang Sun, Xiao-Wei Hao, Ke-Han Wu, Yu-Bo Wang, Wen Tian, Xin Fan, Zezhi Li, Caixia Feng, Xu Chao, Yu-Fan Wang, Yao Liu, Di Li, Wei Cao   +16 more
doaj   +1 more source

Evaluation of the effectiveness and safety of ONO‐2910 for the treatment of diabetic polyneuropathy: An early Phase IIa, multicenter, randomized, placebo‐controlled, double‐blind study in Japanese patients

Journal of Diabetes Investigation, Volume 17, Issue 2, Page 310-320, February 2026.
ABSTRACT Aims/Introduction Diabetic polyneuropathy (DPN) is common in patients with diabetes. Its symptoms include pain, numbness, and impaired neurosensory function. ONO‐2910 promotes Schwann cell differentiation and is being developed for DPN. Materials and Methods This Phase IIa randomized controlled trial evaluated the effectiveness and safety of ...
Yukiko Onishi, Takeshi Osonoi, Norio Takahashi, Toru Takiguchi, Eiichiro Morishima, Yoshimasa Aso, Kenji Sekiguchi, Hideki Kamiya, Jiro Nakamura   +8 more
wiley   +1 more source

Maternal Fructose Intake During Pregnancy Induced the Hepatic Glucose Homeostasis Imbalance in the Offspring by Inhibiting Glucokinase

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
Schematic diagram of the core mechanisms. The study demonstrated that maternal fructose intake during pregnancy led to glucose intolerance and insulin resistance in offspring. The abnormal hepatic glucose metabolism in offspring was associated with decreased GK expression, which was inhibited by DNMT3B.
Yahui Miao, Ziyu Meng, Shihang Chen, Xiaoyu Li, Ting Fang, Xiaoqing Deng, Bei Sun, Liming Chen   +7 more
wiley   +1 more source

Ko‐Assemblierungen regulieren die katalytische Aktivität von Peptidfibrillen

Angewandte Chemie, Volume 138, Issue 2, 9 January 2026.
Katalytische selbstassemblierende Peptide (kSAPs) bilden Fibrillen, die die Retro‐Aldol‐Reaktion von Methodol katalysieren. Die Ko‐Assemblierung mit inaktiven Peptiden reguliert die katalytische Aktivität, indem sie die Zugänglichkeit des Substrats und den Abstand zum nukleophilen Lysin verändert.
Albin Lahu, Shao‐Lin Wu, Maximilian Schuler, Francesca Mazzotta, Ardit Ramadani, Emirhan Koca, Ingo Lieberwirth, Katharina Landfester, Torsten John, David Y. W. Ng, Tanja Weil   +10 more
wiley   +1 more source

HEREDITARY FRUCTOSE INTOLERANCE – CASE REPORT

Zdravniški Vestnik, 2002
Background. Hereditary fructose intolerance is a rare inborn error of carbohydrate metabolism that presents with hypoglicemia, metabolic acidosis and liver decompensation when the patient is exposed to fructose.
Jernej Brecelj, Gordana Logar-Car, Henrik Peče   +2 more
doaj  

Activation of AMPD2 drives metabolic dysregulation and liver disease in mice with hereditary fructose intolerance

Communications Biology
Hereditary fructose intolerance (HFI) is a painful and potentially lethal genetic disease caused by a mutation in aldolase B resulting in accumulation of fructose-1-phosphate (F1P).
Ana Andres-Hernando, David J. Orlicky, Masanari Kuwabara, Mehdi A. Fini, Dean R. Tolan, Richard J. Johnson, Miguel A. Lanaspa   +6 more
doaj   +1 more source

Activity of Carbohydrate Metabolism Enzymes in Streptomyces imbricatus, Producing Imbricin in Controlled Biosynthesis of the Antibiotic

Антибиотики и Химиотерапия, 2020
Changes in the fermentative activity of Streptomyces imbricatus under the conditions of stimulated biosynthesis of imbricin with addition of a crude endoregulator to the medium were studied. The activity of the two main enzymes of the glycolysis, i.
O. V. Topkova, E. P. Yakovleva, V. A. Kolodyaznaya   +2 more
doaj