Results 31 to 40 of about 21,208,579 (315)

Aldolase B knockdown prevents high glucose-induced methylglyoxal overproduction and cellular dysfunction in endothelial cells. [PDF]

PLoS ONE, 2012
We used cultured endothelial cells as a model to examine whether up-regulation of aldolase B and enhanced methylglyoxal (MG) formation play an important role in high glucose-induced overproduction of advanced glycosylation endproducts (AGEs), oxidative ...
Jianghai Liu, Timothy Chun-Ping Mak, Ali Banigesh, Kaushik Desai, Rui Wang, Lingyun Wu   +5 more
doaj   +1 more source

Modifying the stereochemistry of an enzyme-catalyzed reaction by directed evolution [PDF]

, 2003
Aldolases have potential as tools for the synthesis of stereochemically complex carbohydrates. Here, we show that directed evolution can be used to alter the stereochemical course of the reaction catalyzed by tagatose-1,6-bisphosphate aldolase.
A. Berry, A. Nelson, AKANUMA, Berry, Blom, Buchholz, Cherry, Crameri, Fessner, Fong, G. J. Williams, Giver, Hall, Jaeger, Kumamaru, Liebeton, Matsumura, May, Merritt, Nakajima, Plater, QAMAR, Raillard, Rutter, S. Domann, Stemmer, Zgiby, Zhao   +27 more
core   +2 more sources

Acute rhabdomyolysis

Нервно-мышечные болезни, 2015
Rhabdomyolysis results from the rapid breakdown of skeletal muscle fibers, which leads to leakage of potentially toxic cellular contents into the systemic circulation. Acquired causes by direct injury to the sarcolemma are the most frequent.
Pascale de Lonlay, Asmaa Mamoune, Yamina Hamel, Michel Bahuau, Sabrina Vergnaud, Moniqu Piraud, Lætitia Lallemand, Marie-Ange Nguyen More, Mai Thao Vio, Norma Beatriz Romero   +9 more
doaj   +1 more source

Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1*

Journal of Biological Chemistry, 1996
Hypoxia-inducible factor 1 (HIF-1) is a basic helix-loop-helix transcription factor which is expressed when mammalian cells are subjected to hypoxia and which activates transcription of genes encoding erythropoietin, vascular endothelial growth factor ...
G. Semenza, B. Jiang, S. Leung, R. Passantino, J. Concordet, P. Maire, A. Giallongo   +6 more
semanticscholar   +1 more source

Structure of Tagatose-1,6-bisphosphate Aldolase. Insight into chiral discrimination, mechanism, and specificity of class II aldolases [PDF]

, 2002
Tagatose-1,6-bisphosphate aldolase (TBPA) is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate.
Alan Berry, Anastassis, Barton, Blom, Blom, Brünger, C. Ian Watt, Charles S. Bond, Chevrier, Collins, Cooper, Cowtan, David R. Hall, Erion, Gefflaut, Goodford, Gordon A. Leonard, Hall, Heine, Jones, Kraulis, Marrs, Merritt, Morris, Murshodov, Otwinowski, Otwinowski, Plater, Qamar, Reizer, Schoevaart, Sheldrick, Takayama, van Aalten, von der Osten, William N. Hunter, Wong, Wouters, Zgiby, Zgiby   +39 more
core   +1 more source

Investigation into the Mode of Phosphate Activation in the 4-Hydroxy-4-Methyl-2-Oxoglutarate/4-Carboxy-4-Hydroxy-2-Oxoadipate Aldolase from Pseudomonas putida F1. [PDF]

PLoS ONE, 2016
The 4-hydroxy-4-methyl-2-oxoglutarate (HMG)/4-carboxy-4-hydroxy-2-oxoadipate (CHA) aldolase is the last enzyme of both the gallate and protocatechuate 4,5-cleavage pathways which links aromatic catabolism to central cellular metabolism.
Scott Mazurkewich, Stephen Y K Seah
doaj   +1 more source

Therapeutic Targeting of Aldolase A Interactions Inhibits Lung Cancer Metastasis and Prolongs Survival.

Cancer Research, 2019
Cancer metabolic reprogramming promotes tumorigenesis and metastasis, however, the underlying molecular mechanisms are still being uncovered. In this study, we show that the glycolytic enzyme aldolase A (ALDOA) is a key enzyme involved in lung cancer ...
Yu-Chan Chang, Jean Chiou, Yi-Fang Yang, Chia-Yi Su, Yuan-Feng Lin, Chia-Ning Yang, P. Lu, Ming-Shyan Huang, Chih-Jen Yang, M. Hsiao   +9 more
semanticscholar   +1 more source

Levels of C-reactive protein, creatine kinase-muscle and aldolase A are suitable biomarkers to detect the risk factors for osteoarthritic disorders: A novel diagnostic protocol

Caspian Journal of Internal Medicine, 2019
Background: C-reactive protein (CRP), creatine kinase-muscle (CK-MM) and aldolase A (AldoA) levels are predicted to be realistic biomarkers of osteoarthritic disorders (OADs). The objective of the study was to evaluate the levels of CRP, CK-MM, and AldoA
A. Ganguly
semanticscholar   +1 more source

The Binding of Plasmodium falciparum Adhesins and Erythrocyte Invasion Proteins to Aldolase Is Enhanced by Phosphorylation.

PLoS ONE, 2016
Aldolase has been implicated as a protein coupling the actomyosin motor and cell surface adhesins involved in motility and host cell invasion in the human malaria parasite Plasmodium falciparum. It binds to the cytoplasmic domain (CTD) of type 1 membrane
Suraya A Diaz, Stephen R Martin, Steven A Howell, Munira Grainger, Robert W Moon, Judith L Green, Anthony A Holder   +6 more
doaj   +1 more source

Impact of Cabozantinib Exposure on Proteinuria and Muscle Toxicity in Patients with Unresectable Hepatocellular Carcinoma

Pharmaceuticals, 2022
This prospective study investigated the impact of cabozantinib exposure on proteinuria and muscle toxicity, in a cohort of 14 Japanese patients with unresectable hepatocellular carcinoma (uHCC).
Hironao Okubo, Hitoshi Ando, Yusuke Takasaki, Eisuke Nakadera, Yuka Fukuo, Shuichiro Shiina, Kenichi Ikejima   +6 more
doaj   +1 more source