Results 71 to 80 of about 21,208,579 (315)

3D STRUCTURE AND FUNCTION ANALYSIS OF RECOMBINANT ALDII PROTEIN FROM Uncultured Acidilobus sp. USING I-TASSER

Jurnal Kimia Riset
The AldII protein is a new recombinant protein produced from a novel gene obtained via a metagenome approach. Previous studies showed that this protein is strong and has the same metal binding aspect as the class II Aldolase enzyme.
Nishia Waya Meray, Suharti Suharti, Akhmaloka Akhmaloka   +2 more
doaj   +1 more source

Ascorbic Acid Significantly Decreases Creatine Kinase Plasma Levels in an Animal Model of Statin/Fibrate-Induced Myopathy

Advances in Pharmacological and Pharmaceutical Sciences, 2021
Background. Myopathy is one of the side effects of lipid-lowering drugs, especially statins and particularly when combined with a fibrate. To diagnose myopathy and determine its severity, the plasma levels of three enzymes, creatine kinase (CK), aldolase,
Mohsen Zabihi, Fatemeh Askarian, Seyedhossein Hekmatimoghaddam, Mohammadreza Rashidi Nooshabadi, Mohammad Sajjad Zabihi, Seyed Ruhollah Mousavinasab   +5 more
doaj   +1 more source

Nanobodies as tools to understand, diagnose, and treat African trypanosomiasis [PDF]

, 2017
African trypanosomes are strictly extracellular protozoan parasites that cause diseases in humans and livestock and significantly affect the economic development of sub-Saharan Africa.
Caljon, Guy, De Baetselier, Patrick, Magez, Stefan, Stijlemans, Benoit, Van Den Abbeele, Jan, Van Ginderachter, Jo A   +5 more
core   +1 more source

Systematic Metabolic Engineering and Model‐Guided Optimization for High‐Level Production of L‐Theanine From Xylose in Escherichia Coli

Advanced Science, EarlyView.
This study is pioneering in constructing the shortest known synthetic pathway for L‐theanine production from xylose within E coli. Through comprehensive metabolic engineering strategies, our engineered strain achieved the highest reported L‐theanine titer from xylose, with a titer of 95.42 g/L, and a yield of 0.55 g/g.
Haolin Han, Boyuan Xue, Guangqi Shan, Meng Meng, Shaojie Wang, Haijia Su   +5 more
wiley   +1 more source

The Hepatocellular Hypoxia Criteria:2’Nitroimidazole Effect on Hepatocyte Carbohydrate Metabolizing Enzymes [PDF]

, 2008
Aim: to understand the 2’-nitroimidazole induced hypoxia and liver cell interaction, we proposed a “Hapatocellular Hypoxia Criteria”.
Rakesh Sharma
core   +1 more source

Chronic high‐fat diet induces multi‐organ dysfunction and metabolic homeostasis disruption in Macaca fascicularis

Animal Models and Experimental Medicine, EarlyView.
An 18‐month HFD successfully established a translational Macaca fascicularis model replicating key metabolic disorders (MASH, diabetes, cardiac hypertrophy). MASH was determined by liver biopsy histology, the presence steatosis, inflammatory infiltration, hepatocytic ballooning, and fibrosis were considered as MASH; diabetes was diagnosed according to ...
Hongyi Chen, Wei Liu, Dan Zhou, Shuhua Liu, Yalun Guan, Zongyu Miao, Lei Cai, Xuejiao Li, Yunfeng Li, Zhongqiang Huang, Yi Jin, Ge Li, Yu Zhang   +12 more
wiley   +1 more source

Genomewide and Enzymatic Analysis Reveals Efficient d-Galacturonic Acid Metabolism in the Basidiomycete Yeast Rhodosporidium toruloides. [PDF]

, 2019
Biorefining of renewable feedstocks is one of the most promising routes to replace fossil-based products. Since many common fermentation hosts, such as Saccharomyces cerevisiae, are naturally unable to convert many component plant cell wall ...
Arkin, Adam P, Benz, J Philipp, Coradetti, Samuel T, Dueber, John E, Geiselman, Gina M, Hach, Christina A, Hackhofer, Magdalena A, Magosch, Sonja, Protzko, Ryan J, Skerker, Jeffrey M, Thieme, Nils   +10 more
core   +1 more source

Formate Excretion in Urine of Rats Fed Dimethylaminoazobenzene-rich Diets: The Possibility of Formate Formation from D-Lactate [PDF]

, 2008
This experiment was carried out to evaluate the possibility of degradation of d-lactate into formate and acetaldehyde. In order to induce hyperproduction of d-lactate in rats.
Kawase, Michi, Kitamura, Yuki, Ohmori, Shinji   +2 more
core   +1 more source

Catalytic Amyloids: Turning Fibrils Into Biocatalysts

Chemistry – A European Journal, EarlyView.
Amyloids, traditionally associated with diseases, have emerged as versatile catalytic scaffolds. From natural amyloid sequences to bioinspired and de novo designs, we highlight strategies to construct catalytic active sites and anchor enzymes onto fibrils, creating versatile nanomaterials with tunable activities. ABSTRACT Amyloids have been regarded as
Alessandra Esposito, Linda Leone, Flavia Nastri, Angela Lombardi   +3 more
wiley   +1 more source

Blockade of PGK1 and ALDOA enhances bilirubin control of Th17 cells in Crohn’s disease

Communications Biology, 2022
Unconjugated bilirubin modulates Th17-cell metabolism in Crohn’s disease by limiting glycolysis and through downregulation of phosphoglycerate-kinase-1 (PGK1) and aldolase-A (ALDOA).
Marta Vuerich, Na Wang, Jonathon J. Graham, Li Gao, Wei Zhang, Ahmadreza Kalbasi, Lina Zhang, Eva Csizmadia, Jason Hristopoulos, Yun Ma, Efi Kokkotou, Adam S. Cheifetz, Simon C. Robson, Maria Serena Longhi   +13 more
doaj   +1 more source