Results 41 to 50 of about 84,187 (148)

Captopril challenge test in the diagnosis of primary aldosteronism: consistency between 1- and 2- h sampling

Frontiers in Endocrinology, 2023
ObjectiveTo examine the consistency of plasma aldosterone concentration at 1 and 2 h in the captopril challenge test (CCT) and to explore the possibility of replacing 2-h aldosterone concentration with 1-h aldosterone concentration for diagnosis of ...
Xinyu Liu, Chao Guo, Jin Bian, Sufang Hao, Ying Lou, Huimin Zhang, Xianliang Zhou, Jun Cai, Wenjun Ma   +8 more
doaj   +1 more source

Inhibition of NPC Intracellular Cholesterol Transporter 1 Dually Regulates Aldosterone Secretion Via the Steroidogenic Acute Regulatory‐Related Lipid Transfer Domain‐3‐Voltage‐Dependent Anion Channel 1 Axis and Inositol 1,4,5‐Trisphosphate Receptor Type 3‐Calcium Signaling

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Aldosterone‐producing adenomas, a prevalent cause of endocrine hypertension, arise from uncontrolled aldosterone production. NPC1 (NPC intracellular cholesterol transporter 1) is a cholesterol transporter located on the lysosomal limiting ...
Jun Chen, Miaoyun Chen, Jinbo Hu, Zhipeng Wu, Hongji Li, Wuchao Li, Furong He, Chuan Peng, Yong Xu, Wei Huang, Rufei Gao, Qifu Li, Linqiang Ma, Shumin Yang   +13 more
doaj   +1 more source

Despite increasing aldosterone, elevated potassium is not necessary for activating aldosterone‐sensitive HSD2 neurons or sodium appetite

Physiological Reports, 2021
Restricting dietary sodium promotes sodium appetite in rats. Prolonged sodium restriction increases plasma potassium (pK), and elevated pK is largely responsible for a concurrent increase in aldosterone, which helps promote sodium appetite.
Frederico S. Fazan, Eduardo Colombari, Arthur D. Loewy, Joel C. Geerling   +3 more
doaj   +1 more source

Role of the Renin-Angiotensin-Aldosterone System beyond Blood Pressure Regulation: Molecular and Cellular Mechanisms Involved in End-Organ Damage during Arterial Hypertension

International Journal of Molecular Sciences, 2016
Arterial hypertension is a common condition worldwide and an important predictor of several complicated diseases. Arterial hypertension can be triggered by many factors, including physiological, genetic, and lifestyle causes.
N. Muñoz-Durango, Cristóbal A. Fuentes, Andrés E. Castillo, L. González-Gómez, A. Vecchiola, C. Fardella, A. Kalergis   +6 more
semanticscholar   +1 more source

Distal renal tubules are deficient in aggresome formation and autophagy upon aldosterone administration.

PLoS ONE, 2014
Prolonged elevations of plasma aldosterone levels are associated with renal pathogenesis. We hypothesized that renal distress could be imposed by an augmented aldosterone-induced protein turnover challenging cellular protein degradation systems of the ...
Muhammad Umar Cheema, Helle Hasager Damkier, Jakob Nielsen, Ebbe Toftgaard Poulsen, Jan J Enghild, Robert A Fenton, Jeppe Praetorius   +6 more
doaj   +1 more source

THE GENDER FEATURES OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM IN HYPERTENSIVE PATIENTS

Рациональная фармакотерапия в кардиологии, 2016
Aim. To study the correlation of the renin-angiotensin-aldosterone system (RAAS) activity with the female sex hormone levels and markers of target organ damage in patients with arterial hypertension (HT).Material and methods. Patients with HT (20 men and
V. I. Podzolkov, A. E. Bragina, Ju. N. Rodionova, E. K. Panferova   +3 more
doaj   +1 more source

The Biology of Normal Zona Glomerulosa and Aldosterone-Producing Adenoma: Pathological Implications

Endocrine reviews, 2018
The identification of several germline and somatic ion channel mutations in aldosterone-producing adenomas (APAs) and detection of cell clusters that can be responsible for excess aldosterone production, as well as the isolation of autoantibodies ...
T. Seccia, B. Caroccia, E. Gomez-Sanchez, C. Gomez-Sanchez, G. Rossi   +4 more
semanticscholar   +1 more source

Possible Underlying Mechanisms Responsible for Aldosterone and Mineralocorticoid Receptor–Dependent Renal Injury

Journal of Pharmacological Sciences, 2008
There is increasing evidence indicating the roles of aldosterone and mineralocorticoid receptor (MR) in the pathogenesis of renal injury. In rats, chronic treatment with aldosterone and salt results in severe proteinuria and renal tissue injury ...
Hideyasu Kiyomoto, Kazi Rafiq, Mahbub Mostofa, Akira Nishiyama   +3 more
doaj   +1 more source

Aldosterone and Mineralocorticoid Receptors—Physiology and Pathophysiology

International Journal of Molecular Sciences, 2017
Aldosterone is a uniquely terrestrial hormone, first appearing in lungfish, which have both gills and lungs. Mineralocorticoid receptors (MRs), on the other hand, evolved much earlier, and are found in cartilaginous and bony fish, presumptive ligand ...
J. Funder
semanticscholar   +1 more source

Activating mutations in CTNNB1 in aldosterone producing adenomas

Scientific Reports, 2016
Primary aldosteronism (PA) is the most common cause of secondary hypertension with a prevalence of 5–10% in unreferred hypertensive patients. Aldosterone producing adenomas (APAs) constitute a large proportion of PA cases and represent a surgically ...
T. Åkerström, R. Maharjan, Holger Sven Willenberg, K. Cupisti, Julian C. Y. Ip, Ana Moser, P. Stålberg, B. Robinson, K. Alexander Iwen, H. Dralle, M. Walz, H. Lehnert, S. Sidhu, C. Gomez-Sanchez, P. Hellman, P. Björklund   +15 more
semanticscholar   +1 more source