Results 41 to 50 of about 96,578 (258)
British Journal of Clinical Pharmacology, EarlyView.Aims The aim of this phase 1 trial was to assess the pharmacokinetics, safety and tolerability of balcinrenone (previously AZD9977) in participants with severe renal impairment vs. those with normal renal function. Methods Participants with severe renal impairment (estimated glomerular filtration rate [eGFR] < 30 mL/min/1.73 m2) not on dialysis were ...
Chandrali S. Bhattacharya +10 more
wiley +1 more source
Progesterone: An Enigmatic Ligand for the Mineralocorticoid Receptor [PDF]
arXiv, 2020 The progesterone receptor (PR) mediates progesterone regulation of female reproductive physiology, as well as gene transcription in non-reproductive tissues, such as brain, bone, lung and vasculature, in both women and men. An unusual property of progesterone is its high affinity for the mineralocorticoid receptor (MR), which regulates electrolyte ...
arxiv
Deciphering the skeletal interoceptive circuitry to control bone homeostasis
BMEMat, EarlyView.This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu +7 more
wiley +1 more source
The accessory renal arteries: A systematic review with meta‐analysis
Clinical Anatomy, EarlyView.Abstract The accessory renal arteries (ARAs) are a well‐described variant of the renal vasculature with clinical implications for radiologists, surgeons, and clinicians. The aim of the present systematic review with meta‐analysis was to estimate the pooled prevalence of ARAs, including their variant number, origin, and termination, and to highlight ...
George Triantafyllou +6 more
wiley +1 more source
Redox Biology, 2017 Aldosterone, with pro-oxidation and pro-autophagy capabilities, plays a key role in liver fibrosis. However, the mechanisms underlying aldosterone-promoted liver sinusoidal endothelial cells (LSECs) defenestration remain unknown.
Xiaoying Luo +12 more
doaj +1 more source
Journal of International Medical Research, 2019 Objective Both obstructive sleep apnea–hypopnea syndrome (OSAHS) and type 2 diabetes mellitus (T2DM) are closely related to the renin-angiotensin-aldosterone system.
Jie Zhang, Lin Tian, Lixin Guo
doaj +1 more source
Role of the Renin-Angiotensin System and Aldosterone on Cardiometabolic Syndrome
International Journal of Hypertension, 2011 Aldosterone facilitates cardiovascular damage by increasing blood pressure and through different mechanisms that are independent of its effects on blood pressure.
P. Stiefel +3 more
doaj +1 more source
American Journal of Preventive Cardiology, 2023 Background: Greater attainment of ideal cardiovascular health (ICH) and lower serum aldosterone are associated with lower diabetes risk. Higher levels of ICH are associated with lower aldosterone. The mediational role of aldosterone in the association of
Veena Kesireddy +15 more
doaj
Asian Journal of Andrology, 2018 Emerging evidence indicates that aldosterone and mineralocorticoid receptors (MRs) are associated with the pathogenesis of erectile dysfunction. However, the molecular mechanisms remain largely unknown.
Fei Wu +6 more
doaj +1 more source
European Journal of Heart Failure, Volume 24, Issue 11, Page 2131-2139, November 2022., 2022 Among patients with new‐onset or worsening heart failure (HF) undergoing optimization of HF medical therapy, dose up‐titration of angiotensin‐converting enzyme inhibitor/angiotensin receptor blocker (ACEi/ARB) therapy was associated with lower likelihood of left atrial adverse remodelling (LAAR).
Riccardo M. Inciardi +16 more
wiley +1 more source