Advances in Physiology Education, 2002 Aldosterone plays a pivotal role in electrolyte and fluid homeostasis and thus control of blood pressure. The “classical” view of aldosterone action is that it targets epithelia of the distal colon and renal nephron to stimulate Na+(re)absorption and K+secretion.
Rachell E, Booth +2 more
openaire +2 more sources
Extramitochondrial OPA1 and adrenocortical function [PDF]
, 2013 We have previously described that silencing of the mitochondrial protein OPA1 enhances mitochondrial 27 Ca2+ signaling and aldosterone production in H295R adrenocortical cells.
András Spät +80 more
core +1 more source
Atrial natriuretic factor (ANF) and renin-aldosterone in volume regulation of patients with cirrhosis [PDF]
, 1989 The role of the atrial natriuretic factor and of the main counteracting sodium-retaining principle, the renin-aldosterone system, in acute volume regulation of cirrhosis of the liver has been investigated.
Anderson +46 more
core +1 more source
Campylobacter concisus Impairs Sodium Absorption in Colonic Epithelium via ENaC Dysfunction and Claudin-8 Disruption [PDF]
, 2020 The epithelial sodium channel (ENaC) can increase the colonic absorptive capacity for salt and water. Campylobacter concisus is a common pathogenic epsilonproteobacterium, causing enteritis and diarrhea. It can induce barrier dysfunction in the intestine,
Bereswill, Stefan +15 more
core +2 more sources
Rapid and MR-Independent IK1 activation by aldosterone during ischemia-reperfusion [PDF]
, 2015 In ST elevation myocardial infarction (STEMI) context, clinical studies have shown the deleterious effect of high aldosterone levels on ventricular arrhythmia occurrence and cardiac mortality.
Alexandre, J +8 more
core +3 more sources
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2015 Background We recently reported that normal aldosterone levels are associated with cardiovascular, renal, and metabolic disease in a sample of the US general community (Visit 1).
Alessia Buglioni +8 more
doaj +1 more source
The Effects of Different Calcium Channel Blockers on Aldosterone-Producing Adenoma Cells
Frontiers in Endocrinology, 2020 Purpose: The aim of this study is to examine the effects of different kinds of calcium channel blockers (CCBs) on primary aldosterone-producing adenoma (APA) mainly with KCNJ5 mutations.
Fen Wang +6 more
doaj +1 more source
The Genotype-Based Morphology of Aldosterone-Producing Adrenocortical Disorders and Their Association with Aging [PDF]
Endocrinology and Metabolism, 2021 Primary aldosteronism (PA) is the most common cause of secondary hypertension, and is associated with an increased incidence of cardiovascular events.
Xin Gao +8 more
doaj +1 more source
Aldosterone induces trained immunity: the role of fatty acid synthesis.
Cardiovascular Research, 2019 AIMS Supranormal levels of aldosterone are associated with an increased cardiovascular risk in humans, and with accelerated atherosclerosis in animal models. Atherosclerosis is a low-grade inflammatory disorder, with monocyte-derived macrophages as major
Charlotte D C C van der Heijden +5 more
semanticscholar +1 more source
Vascular dysfunction and fibrosis in stroke-prone spontaneously hypertensive rats: the aldosterone-mineralocorticoid receptor-Nox1 Axis [PDF]
, 2017 Aims: We questioned whether aldosterone and oxidative stress play a role in vascular damage in severe hypertension and investigated the role of Nox1 in this process.
Ceravolo, Graziela +7 more
core +1 more source