Results 31 to 40 of about 161,997 (305)

Captopril challenge test in the diagnosis of primary aldosteronism: consistency between 1- and 2- h sampling

Frontiers in Endocrinology, 2023
ObjectiveTo examine the consistency of plasma aldosterone concentration at 1 and 2 h in the captopril challenge test (CCT) and to explore the possibility of replacing 2-h aldosterone concentration with 1-h aldosterone concentration for diagnosis of ...
Xinyu Liu, Chao Guo, Jin Bian, Sufang Hao, Ying Lou, Huimin Zhang, Xianliang Zhou, Jun Cai, Wenjun Ma   +8 more
doaj   +1 more source

Aldosterone Predicts Cardiovascular, Renal, and Metabolic Disease in the General Community: A 4‐Year Follow‐Up

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2015
Background We recently reported that normal aldosterone levels are associated with cardiovascular, renal, and metabolic disease in a sample of the US general community (Visit 1).
Alessia Buglioni, Valentina Cannone, S. Jeson Sangaralingham, Denise M. Heublein, Christopher G. Scott, Kent R. Bailey, Richard J. Rodeheffer, Riccardo Sarzani, John C. Burnett Jr   +8 more
doaj   +1 more source

Renal potassium handling in rats with subtotal nephrectomy: modeling and analysis [PDF]

, 2018
We sought to decipher the mechanisms underlying the kidney's response to changes in K+ load and intake, under physiological and pathophysiological conditions.
Edwards, Aurelie, Layton, Anita T., Vallon, Volker   +2 more
core   +1 more source

Primary aldosteronism

Gland Surgery, 2020
Primary aldosteronism (PA) is a common cause of secondary hypertension caused by excessive and inappropriate secretion of the hormone aldosterone from one or both adrenal glands. The prevalence of PA ranges from 10% in the general hypertensive population to 20% in resistant hypertension, yet only a small fraction of patients is diagnosed.
Sean M, Wrenn, Anand, Vaidya, Carrie C, Lubitz   +2 more
openaire   +2 more sources

Inhibition of NPC Intracellular Cholesterol Transporter 1 Dually Regulates Aldosterone Secretion Via the Steroidogenic Acute Regulatory‐Related Lipid Transfer Domain‐3‐Voltage‐Dependent Anion Channel 1 Axis and Inositol 1,4,5‐Trisphosphate Receptor Type 3‐Calcium Signaling

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Aldosterone‐producing adenomas, a prevalent cause of endocrine hypertension, arise from uncontrolled aldosterone production. NPC1 (NPC intracellular cholesterol transporter 1) is a cholesterol transporter located on the lysosomal limiting ...
Jun Chen, Miaoyun Chen, Jinbo Hu, Zhipeng Wu, Hongji Li, Wuchao Li, Furong He, Chuan Peng, Yong Xu, Wei Huang, Rufei Gao, Qifu Li, Linqiang Ma, Shumin Yang   +13 more
doaj   +1 more source

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source

Distal renal tubules are deficient in aggresome formation and autophagy upon aldosterone administration.

PLoS ONE, 2014
Prolonged elevations of plasma aldosterone levels are associated with renal pathogenesis. We hypothesized that renal distress could be imposed by an augmented aldosterone-induced protein turnover challenging cellular protein degradation systems of the ...
Muhammad Umar Cheema, Helle Hasager Damkier, Jakob Nielsen, Ebbe Toftgaard Poulsen, Jan J Enghild, Robert A Fenton, Jeppe Praetorius   +6 more
doaj   +1 more source

Downregulated serum 14, 15-epoxyeicosatrienoic acid is associated with abdominal aortic calcification in patients with primary aldosteronism [PDF]

, 2018
Patients with primary aldosteronism (PA) have increased risk of target-organ damage, among which vascular calcification is an important indicator of cardiovascular mortality.
Gao, Jingwei, He, Wanbing, Huang, Hui, Lin, Ying, Liu, Pinming, Shi, Guangzi, Touyz, Rhian M., Yan, Li, Zhang, Shaoling   +8 more
core   +1 more source

Possible Underlying Mechanisms Responsible for Aldosterone and Mineralocorticoid Receptor–Dependent Renal Injury

Journal of Pharmacological Sciences, 2008
There is increasing evidence indicating the roles of aldosterone and mineralocorticoid receptor (MR) in the pathogenesis of renal injury. In rats, chronic treatment with aldosterone and salt results in severe proteinuria and renal tissue injury ...
Hideyasu Kiyomoto, Kazi Rafiq, Mahbub Mostofa, Akira Nishiyama   +3 more
doaj   +1 more source

Indicators of humoral regulation of the circulatory system in obese patients [PDF]

Наука и инновации в медицине, 2020
Objectives to study the indicators of humoral regulation of circulatory system in obese patients as the predictors of CHF development. Materials and methods.Two groups of 40 patients were formed: the first group consisted of patients with I or II ...
Tatyana S. Zaletova, Svetlana A. Derbeneva, Tatyana B. Feofanova, Andrei A. Katsuba   +3 more
doaj   +1 more source