Results 41 to 50 of about 123,346 (302)

The role of aldosterone and ideal cardiovascular health in incident diabetes: The Jackson Heart Study

American Journal of Preventive Cardiology, 2023
Background: Greater attainment of ideal cardiovascular health (ICH) and lower serum aldosterone are associated with lower diabetes risk. Higher levels of ICH are associated with lower aldosterone. The mediational role of aldosterone in the association of
Veena Kesireddy, Bjorn Kluwe, Neal Pohlman, Songzhu Zhao, Yubo Tan, David Kline, Guy Brock, James B. Odei, Valery S. Effoe, Justin B. Echouffo-Tcheugui, Rita R. Kalyani, Mario Sims, Herman A. Taylor, Morgana Mongraw-Chaffin, Ehimare Akhabue, Joshua J. Joseph   +15 more
doaj   +1 more source

Aldosterone-Induced Hypertension is Sex-Dependent, Mediated by T Cells and Sensitive to GPER Activation

, 2021
Aims: The G protein-coupled estrogen receptor 1 (GPER) may modulate some effects of aldosterone. In addition, G-1 (a GPER agonist) can lower blood pressure (BP) and promote T cell-mediated anti-inflammatory responses. This study aimed to test the effects
Christopher Sobey (7138634), Antony Vinh (9491777), Sophocles Chrissobolis (15137635), Quynh Nhu Dinh (9480314), Henry Diep (9491633), Courtney Judkins (9478289), Hyun Ah Kim (9478493), Grant Drummond (9477542), Narbada Saini (9481148), Brad RS Broughton (20438654)   +9 more
core   +1 more source

Inhibition of NPC Intracellular Cholesterol Transporter 1 Dually Regulates Aldosterone Secretion Via the Steroidogenic Acute Regulatory‐Related Lipid Transfer Domain‐3‐Voltage‐Dependent Anion Channel 1 Axis and Inositol 1,4,5‐Trisphosphate Receptor Type 3‐Calcium Signaling

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Aldosterone‐producing adenomas, a prevalent cause of endocrine hypertension, arise from uncontrolled aldosterone production. NPC1 (NPC intracellular cholesterol transporter 1) is a cholesterol transporter located on the lysosomal limiting ...
Jun Chen, Miaoyun Chen, Jinbo Hu, Zhipeng Wu, Hongji Li, Wuchao Li, Furong He, Chuan Peng, Yong Xu, Wei Huang, Rufei Gao, Qifu Li, Linqiang Ma, Shumin Yang   +13 more
doaj   +1 more source

Extramitochondrial OPA1 and adrenocortical function [PDF]

, 2013
We have previously described that silencing of the mitochondrial protein OPA1 enhances mitochondrial 27 Ca2+ signaling and aldosterone production in H295R adrenocortical cells.
Fülöp, László, Spät András, Szanda, Gergö, Katona, Dávid, Rajki Anikó, Rajki, Anikó, Fülöp László, Szanda Gergő, Spät, András, Katona Dávid   +9 more
core   +2 more sources

Endocrine Hypertension, Adrenal Steroids and Development of a Saliva Based Aldosterone Assay as a Potential Screening Method [PDF]

, 2008
Recent evidence has shown the increased incidence of PA in approximately 15% of the hypertensive population, making a non-invasive and simple screening method for the measurement of aldosterone levels necessary.
Manolopoulou, Jenny
core   +1 more source

Aldosterone Predicts Cardiovascular, Renal, and Metabolic Disease in the General Community: A 4‐Year Follow‐Up

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2015
Background We recently reported that normal aldosterone levels are associated with cardiovascular, renal, and metabolic disease in a sample of the US general community (Visit 1).
Alessia Buglioni, Valentina Cannone, S. Jeson Sangaralingham, Denise M. Heublein, Christopher G. Scott, Kent R. Bailey, Richard J. Rodeheffer, Riccardo Sarzani, John C. Burnett Jr   +8 more
doaj   +1 more source

The Effects of Different Calcium Channel Blockers on Aldosterone-Producing Adenoma Cells

Frontiers in Endocrinology, 2020
Purpose: The aim of this study is to examine the effects of different kinds of calcium channel blockers (CCBs) on primary aldosterone-producing adenoma (APA) mainly with KCNJ5 mutations.
Fen Wang, Fen Wang, Xiaosen Ma, Anli Tong, Yushi Zhang, Jin Wen, Yuxiu Li   +6 more
doaj   +1 more source

HYPER‐RESPONSIVENESS OF ALDOSTERONE TO METOCLOPRAMIDE IN ALDOSTERONISM [PDF]

Clinical Endocrinology, 1982
Metoclopramide, a dopamine antagonist, stimulates aldosterone secretion in normal man. We studied the response of plasma aldosterone, plasma renin activity, cortisol, sodium, potassium and serum prolactin to a 10‐mg intravenous dose of metoclopramide in six dexamethasone suppressed patients with aldosteronism (four with adrenal adenoma, two with ...
Gniadek, T. C., Grekin, Roger J., Gross, Milton D., Villareal, J. Z.   +3 more
openaire   +3 more sources

Indicators of humoral regulation of the circulatory system in obese patients [PDF]

Наука и инновации в медицине, 2020
Objectives to study the indicators of humoral regulation of circulatory system in obese patients as the predictors of CHF development. Materials and methods.Two groups of 40 patients were formed: the first group consisted of patients with I or II ...
Tatyana S. Zaletova, Svetlana A. Derbeneva, Tatyana B. Feofanova, Andrei A. Katsuba   +3 more
doaj   +1 more source

Distal renal tubules are deficient in aggresome formation and autophagy upon aldosterone administration.

PLoS ONE, 2014
Prolonged elevations of plasma aldosterone levels are associated with renal pathogenesis. We hypothesized that renal distress could be imposed by an augmented aldosterone-induced protein turnover challenging cellular protein degradation systems of the ...
Muhammad Umar Cheema, Helle Hasager Damkier, Jakob Nielsen, Ebbe Toftgaard Poulsen, Jan J Enghild, Robert A Fenton, Jeppe Praetorius   +6 more
doaj   +1 more source