Results 41 to 50 of about 25,925 (259)

BIN1 and ALDH1B1 Deficiency in Colonic Smooth Muscle Drives Mitochondrial Dysfunction and Fibrosis in Slow‐Transit Constipation

Advanced Science, EarlyView.
Slow‐transit constipation (STC) is a disabling motility disorder with unclear smooth‐muscle mechanisms. Spatial proteomic analysis of STC patient colon reveals both the central pathogenic role of smooth muscle cells (SMCs) in STC and novel regulators of intestinal motility, BIN1 and ALDH1B1.
Jianbo Liu, Hao Zhang, Wenhao Qiao, Ran Liu, Jie Sun, Xiaopei Li, Qin Li, Dongbo Zhao, Dawei Chen, Jingxin Li, Shuxiao Dong   +10 more
wiley   +1 more source

Severe loss-of-function mutations in the adrenocorticotropin receptor (ACTHR, MC2R) can be found in patients diagnosed with salt-losing adrenal hypoplasia [PDF]

, 2007
Objective Familial glucocorticoid deficiency type I (FGD1) is a rare form of primary adrenal insufficiency resulting from recessive mutations in the ACTH receptor (MC2R, MC2R).
Hindmarsh, PC, Dattani, MT, Achermann, JC, Metherell, LA, Al-Ali, M, Brain, CE, Alzyoud, M, Clark, AJ, Lin, L, Clark, AJL   +9 more
core   +1 more source

Dual‐Network Protein Hydrogels Promote Rapid Hemostasis and Immune‐Regulated Scarless Tissue Regeneration

Advanced Science, EarlyView.
A dual‐network protein hydrogel substantially improves hemostasis and scar‐free healing.The adaptive network maintains intimate tissue contact while providing strong wet adhesion, tunable mechanics, and controlled degradation. Concurrent ROS scavenging and M2 polarization suppress fibrotic pathways, preventing scar formation.
Xiaomei Li, Guorui Zhang, Xinyue Wang, Zhongyu Liu, Ling Yang, Yuhan Bao, Min Wei, Yonglin Chen, Yanfei Ma, Wenbo Sheng, Bo Yu, Bin Li   +11 more
wiley   +1 more source

Dietary Sodium Reduction Reveals Aldosterone Dysregulation in Patients With Essential Hypertension

The Journal of Clinical Hypertension
Dietary sodium reduction affects blood pressure (BP), the renin‐angiotensin‐aldosterone system (RAAS) and natriuretic peptides. Whether baseline levels of these hormones impact BP response to sodium reduction remains unknown.
Camilla L. Duus, Steffen F. Nielsen, Bodil G. Hornstrup, Frank H. Mose, Jesper N. Bech   +4 more
doaj   +1 more source

The Effects of Aldosterone on Hypertension-Associated Kidney Injury in a Tg-hAS Mouse Model

Biology
Hypertension remains a global health challenge due to its high prevalence and association with premature morbidity and mortality. Aldosterone, a mineralocorticoid hormone, and its receptor, the mineralocorticoid receptor (MR), are highly implicated in ...
Huiying Gu, Zhe Chen, Nicole Du, Sisi Yang, Yongqi Yu, Yansheng Du   +5 more
doaj   +1 more source

Extramitochondrial OPA1 and adrenocortical function [PDF]

, 2013
We have previously described that silencing of the mitochondrial protein OPA1 enhances mitochondrial 27 Ca2+ signaling and aldosterone production in H295R adrenocortical cells.
Fülöp, László, Spät András, Szanda, Gergö, Katona, Dávid, Rajki Anikó, Rajki, Anikó, Fülöp László, Szanda Gergő, Spät, András, Katona Dávid   +9 more
core   +1 more source

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source

Aldosterone-Producing Adenomas

, 2019
Aldosterone-producing adenomas (APA) are more common than initially anticipated. APA cause primary aldosteronism (PA), which affect 3-10% of the hypertensive population.
Åkerström, Tobias,, Per Hellman, Tobias Åkerström, Peyman Björklund, Hellman, Per,, Björklund, Peyman,   +5 more
core   +1 more source

The 9+ month marathon: How pregnancy may have shaped human endurance capacities

The Anatomical Record, EarlyView.
Abstract Anthropology has long considered the evolution of our uniquely human endurance capacities to be the result of selection upon anatomical and physiological features imposed by the demands of thermoregulation and resource acquisition, particularly during the demands of persistence hunting. Research has focused on the anatomical changes present in
Cara Ocobock
wiley   +1 more source

Modern competency‐based teaching of human sexual development

Anatomical Sciences Education, EarlyView.
Abstract Embryology is an integral part of anatomy and a key subject in basic medical education. The development of the sexual tract, which is closely associated with the formation of the urinary tract and the organs of continence, is particularly complex and relevant for many medical disciplines.
Elisabeth Eppler, Alessandro Bilella, Christian M. Hammer   +2 more
wiley   +1 more source