Results 41 to 50 of about 119,651 (301)

Captopril challenge test in the diagnosis of primary aldosteronism: consistency between 1- and 2- h sampling

Frontiers in Endocrinology, 2023
ObjectiveTo examine the consistency of plasma aldosterone concentration at 1 and 2 h in the captopril challenge test (CCT) and to explore the possibility of replacing 2-h aldosterone concentration with 1-h aldosterone concentration for diagnosis of ...
Xinyu Liu, Chao Guo, Jin Bian, Sufang Hao, Ying Lou, Huimin Zhang, Xianliang Zhou, Jun Cai, Wenjun Ma   +8 more
doaj   +1 more source

Inhibition of NPC Intracellular Cholesterol Transporter 1 Dually Regulates Aldosterone Secretion Via the Steroidogenic Acute Regulatory‐Related Lipid Transfer Domain‐3‐Voltage‐Dependent Anion Channel 1 Axis and Inositol 1,4,5‐Trisphosphate Receptor Type 3‐Calcium Signaling

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Aldosterone‐producing adenomas, a prevalent cause of endocrine hypertension, arise from uncontrolled aldosterone production. NPC1 (NPC intracellular cholesterol transporter 1) is a cholesterol transporter located on the lysosomal limiting ...
Jun Chen, Miaoyun Chen, Jinbo Hu, Zhipeng Wu, Hongji Li, Wuchao Li, Furong He, Chuan Peng, Yong Xu, Wei Huang, Rufei Gao, Qifu Li, Linqiang Ma, Shumin Yang   +13 more
doaj   +1 more source

Despite increasing aldosterone, elevated potassium is not necessary for activating aldosterone‐sensitive HSD2 neurons or sodium appetite

Physiological Reports, 2021
Restricting dietary sodium promotes sodium appetite in rats. Prolonged sodium restriction increases plasma potassium (pK), and elevated pK is largely responsible for a concurrent increase in aldosterone, which helps promote sodium appetite.
Frederico S. Fazan, Eduardo Colombari, Arthur D. Loewy, Joel C. Geerling   +3 more
doaj   +1 more source

Indicators of humoral regulation of the circulatory system in obese patients [PDF]

Наука и инновации в медицине, 2020
Objectives to study the indicators of humoral regulation of circulatory system in obese patients as the predictors of CHF development. Materials and methods.Two groups of 40 patients were formed: the first group consisted of patients with I or II ...
Tatyana S. Zaletova, Svetlana A. Derbeneva, Tatyana B. Feofanova, Andrei A. Katsuba   +3 more
doaj   +1 more source

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source

Extramitochondrial OPA1 and adrenocortical function [PDF]

, 2013
We have previously described that silencing of the mitochondrial protein OPA1 enhances mitochondrial 27 Ca2+ signaling and aldosterone production in H295R adrenocortical cells.
Fülöp, László, Spät András, Szanda, Gergö, Katona, Dávid, Rajki Anikó, Rajki, Anikó, Fülöp László, Szanda Gergő, Spät, András, Katona Dávid   +9 more
core   +2 more sources

HYPER‐RESPONSIVENESS OF ALDOSTERONE TO METOCLOPRAMIDE IN ALDOSTERONISM [PDF]

Clinical Endocrinology, 1982
Metoclopramide, a dopamine antagonist, stimulates aldosterone secretion in normal man. We studied the response of plasma aldosterone, plasma renin activity, cortisol, sodium, potassium and serum prolactin to a 10‐mg intravenous dose of metoclopramide in six dexamethasone suppressed patients with aldosteronism (four with adrenal adenoma, two with ...
Gniadek, T. C., Grekin, Roger J., Gross, Milton D., Villareal, J. Z.   +3 more
openaire   +3 more sources

Distal renal tubules are deficient in aggresome formation and autophagy upon aldosterone administration.

PLoS ONE, 2014
Prolonged elevations of plasma aldosterone levels are associated with renal pathogenesis. We hypothesized that renal distress could be imposed by an augmented aldosterone-induced protein turnover challenging cellular protein degradation systems of the ...
Muhammad Umar Cheema, Helle Hasager Damkier, Jakob Nielsen, Ebbe Toftgaard Poulsen, Jan J Enghild, Robert A Fenton, Jeppe Praetorius   +6 more
doaj   +1 more source

Aldosterone-Induced Hypertension is Sex-Dependent, Mediated by T Cells and Sensitive to GPER Activation

, 2021
Aims: The G protein-coupled estrogen receptor 1 (GPER) may modulate some effects of aldosterone. In addition, G-1 (a GPER agonist) can lower blood pressure (BP) and promote T cell-mediated anti-inflammatory responses. This study aimed to test the effects
Christopher Sobey (7138634), Antony Vinh (9491777), Sophocles Chrissobolis (15137635), Quynh Nhu Dinh (9480314), Henry Diep (9491633), Courtney Judkins (9478289), Hyun Ah Kim (9478493), Grant Drummond (9477542), Narbada Saini (9481148), Brad RS Broughton (20438654)   +9 more
core   +1 more source

Possible Underlying Mechanisms Responsible for Aldosterone and Mineralocorticoid Receptor–Dependent Renal Injury

Journal of Pharmacological Sciences, 2008
There is increasing evidence indicating the roles of aldosterone and mineralocorticoid receptor (MR) in the pathogenesis of renal injury. In rats, chronic treatment with aldosterone and salt results in severe proteinuria and renal tissue injury ...
Hideyasu Kiyomoto, Kazi Rafiq, Mahbub Mostofa, Akira Nishiyama   +3 more
doaj   +1 more source