Development of Bone Targeting Drugs. [PDF]
, 2017 The skeletal system, comprising bones, ligaments, cartilage and their connective tissues, is critical for the structure and support of the body. Diseases that affect the skeletal system can be difficult to treat, mainly because of the avascular cartilage
Alméciga-Díaz, Carlos J. +6 more
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Differences in In Vitro Disintegration Time among Canadian Brand and Generic Bisphosphonates
Journal of Osteoporosis, 2014 The objective of this study was to compare the disintegration times among Canadian-marketed brand (alendronate 70 mg, alendronate 70 mg plus vitamin D 5600 IU, and risedronate 35 mg) and generic (Novo-alendronate 70 mg and Apo-alendronate 70 mg) once ...
Wojciech P. Olszynski +2 more
doaj +1 more source
Orthopaedic Surgery, 2021 Objective To compare the preventive effects of teriparatide and alendronate on the progression of vertebral body collapse in postmenopausal single‐level Kümmell's disease (KD).
Peng‐guo Gou +8 more
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Decreased risk of breast cancer associated with oral bisphosphonate therapy [PDF]
, 2012 Preclinical studies and adjuvant trials using bisphosphonates have found them to have an antitumor effect. Although major advances have been made in chemoprevention strategies with selective estrogen receptor modulators and aromatase inhibitors, their ...
Brufsky, A, Mathew, A
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Effects of water-based exercise on bone health of middle-aged and older adults:A systematic review and meta-analysis [PDF]
, 2017 Background: Age-related bone loss is a major health concern. Only exercises associated with high-impact and mechanical loading have been linked to a positive effect on bone turnover; however, these types of exercises may not always be appropriate for ...
Climstein, Mike +3 more
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Coping with complexity: working beyond the guidelines for patients with multimorbidities [PDF]
, 2015 Primary care physicians believe they are delivering evidence-based care, understanding that adherence to evidence-based clinical guidelines results in tangible benefits in the populations for which they were developed.
Treadwell, Julian
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Alendronate induces anti-migratory effects and inhibition of neutral phosphatases in UMR106 osteosarcoma cells [PDF]
, 2007 Bisphosphonates are nonhydrolysable pyrophosphate analogues that prevent bone loss in several types of cancer. However, the mechanisms of anticancer action of bisphosphonates are not completely known.
Bruzzone, L. +2 more
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European Cells & MaterialsBackground: Fracture is a common skeletal disorder, and fracture healing is a complex biological process. The Wingless-Int-Integrated/beta-catenin (Wnt/β-catenin) signaling pathway plays an important role in bone formation and fracture healing.
ZW Sun, QL Zhu, JP Gong, YH Sui, XY Liu
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Effect of alendronate and platelet-rich plasma in tendon-bones integration in sheep anterior cruciate ligament surgery [PDF]
Journal of Pharmacy & Pharmacognosy ResearchContext: Anterior cruciate ligament (ACL) reconstruction often faces challenges due to poor integration of the tendon with bone. Aims: To evaluate the potential benefits of alendronate and platelet-rich plasma (PRP) in enhancing tendon-to-bone ...
Tangkas Sibarani +3 more
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Alendronate treatment results in similar levels of trabecular bone remodeling in the femoral neck and vertebra [PDF]
, 2009 Introduction Bone turnover suppression in sites that already have a low surface-based remodeling rate may lead to oversuppression that could have negative effects on the biomechanical properties of bone.
Allen, Matthew R. +2 more
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