Results 71 to 80 of about 383,882 (262)
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells
FEBS Open Bio, EarlyView.RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour +2 more
wiley +1 more source
Neoplasia: An International Journal for Oncology Research, 2009 Background: The development of noninvasive molecular imaging approaches has the potential to improve management of cancer. Methods: In this study, we demonstrate the potential of noninvasive topical delivery of an epidermal growth factor-Alexa 647 (EGF ...
Nitin Nitin +5 more
doaj +1 more source
, 2017 alexae. Dynamine alexae Peñalver & Grimaldi, 2006 Nymphalidae: Biblidinae. Dominican Republic, Cordillera Septentrional between Santago and Puerto Plata, Dominican Amber; Aquitanian, early Miocene. Depository: AMNH (holotype, DR-18-2). Published figures: Peñalver & Grimaldi (2006: Figs 3–5).
openaire +2 more sources
FEBS Open Bio, EarlyView.In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara +3 more
wiley +1 more source
Doing Virtual Companionship with Alexa
Social InteractionTechnologists often claim that virtual assistants, e.g., smart speakers, can offer 'smart companionship for independent older people'. However, the concept of companionship manifested by such technologies is rarely explained further.
Lauren Hall, Saul Albert, Elizabeth Peel
doaj +1 more source
QDs versus Alexa: reality of promising tools for immunocytochemistry
Journal of Nanobiotechnology, 2009 Background The unique photonic properties of the recently developed fluorescent semiconductor nanocrystals (QDs) have made them a potential tool in biological research. However, QDs are not yet a part of routine laboratory techniques.
Castell Onofre +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source
Reporter Assay for Endo/Lysosomal Escape of Toxin-Based Therapeutics
Toxins, 2014 Protein-based therapeutics with cytosolic targets are capable of exhibiting their therapeutic effect once they have escaped from the endosomes or lysosomes.
Roger Gilabert-Oriol +8 more
doaj +1 more source