Results 71 to 80 of about 442,016 (297)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
, 2018 "The Alexa Experiment" is an autoethnographic and performative project which explores living with the artificially intelligent home assistant, the Amazon Alexa. This Experiment evaluates the device outside of intended consumer uses in hopes to understand
Micak, Katie
core +1 more source
A first look into Alexa's interaction security [PDF]
Proceedings of the 15th International Conference on emerging Networking EXperiments and Technologies, 2019 This work was supported by the Spanish MINECO under contractTEC2017-90034-C2-1-R (ALLIANCE)
Castell Uroz, Ismael +3 more
openaire +1 more source
Amazon Alexa Raspberry Pi -ympäristössä [PDF]
, 2021 Opinnäytetyön aiheena oli tutustua Raspberry Pi-tietokoneeseen ja asentaa siihen Amazonin virtuaaliassistentti Alexa ja testata sen toimintoja Raspberry Pi-ympäristössä.
Lintula, Aleksa
core
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
, 1915 Date:1915Alexa Simmons accepted a job at Victoria River Downs (VRD) in the Territory which at the time was the largest cattle station in the world joining her sister Natalie who was the governess there.
Bates, Alexa
core +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Author Correction: Hippocampal oxytocin receptors are necessary for discrimination of social stimuli
Nature Communications, 2018 The original version of this Article contained an error in the spelling of the author Alexa H. Veenema, which was incorrectly given as Alexa Veenema. This has now been corrected in both the PDF and HTML versions of the Article.
Tara Raam +4 more
doaj +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source