Results 91 to 100 of about 442,016 (297)
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells
FEBS Open Bio, EarlyView.RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour +2 more
wiley +1 more source
Reporter Assay for Endo/Lysosomal Escape of Toxin-Based Therapeutics
Toxins, 2014 Protein-based therapeutics with cytosolic targets are capable of exhibiting their therapeutic effect once they have escaped from the endosomes or lysosomes.
Roger Gilabert-Oriol +8 more
doaj +1 more source
On edge: an interview with Alexa Wright
, 2010 The production of a normative human body is a vital means of social control. In an interview with Stefan Szczelkun, artist Alexa Wright explains how her work experiments with the defended boundaries of the human/self, and the affects unleashed by their ...
Szczelkun, S.
core
FEBS Open Bio, EarlyView.Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source
Doing Virtual Companionship with Alexa
Social InteractionTechnologists often claim that virtual assistants, e.g., smart speakers, can offer 'smart companionship for independent older people'. However, the concept of companionship manifested by such technologies is rarely explained further.
Lauren Hall, Saul Albert, Elizabeth Peel
doaj +1 more source
BMJ Health & Care Informatics, 2019 Objective To assess the quality and accuracy of the voice assistants (VAs), Amazon Alexa, Siri and Google Assistant, in answering consumer health questions about vaccine safety and use.Methods Responses of each VA to 54 questions related to vaccination ...
Emily Couvillon Alagha +1 more
doaj +1 more source
[Dr. Alexa Abrenica delivers lecture on womanhood]
, 1998 Dr. Alexa Abrenica, faculty member of the Psychology Dept. and holder of the John Gokongwei Professorial Chair for Asian Studies, delivered her lecture entitled Womanhood at the crossroads: the Lumad ...
Abrenica, Alexa P.
core
FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source