Results 21 to 30 of about 774,994 (289)
BMC Neurology, 2020 Background Alexander disease is a rare neurological disease characterized by progressive spastic quadriparesis and bulbar palsy. Moreover, certain patients with adult-onset Alexander disease were often misdiagnosed as other neurodegenerative disorders ...
Jongkyu Park +3 more
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Alexander the Great: Head to Head with CTE (Chronic Traumatic Encephalopathy) [PDF]
Athens Journal of History, 2017 One of history’s lingering questions involves the dramatic personality and behavior changes of Alexander the Great. How did a man who was regarded as intelligent, charismatic, compassionate, judicious and composed become increasingly irrational, paranoid,
Alexandra F. Morris
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Alexander Disease Without White Matter Lesions
Pediatric Neurology Briefs, 2006 Seven patients with atypical Alexander disease, showing signs of medulla and spinal cord involvement and little evidence of leukoencephalopathy, are reported from University Medical Center, Amsterdam, the Netherlands; and centers in the UK, USA, Canada ...
J Gordon Millichap
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Frontiers in Immunology, 2022 The viral transactivator Tax plays a key role in HTLV-1 reactivation and de novo infection. Previous approaches focused on the histone deacetylase inhibitor (HDACi) Valproate as a latency-reversing agent to boost Tax expression and expose infected cells ...
Annika P. Schnell +5 more
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Diagnostic and therapeutic considerations in idiopathic hypereosinophilia with warm autoimmune hemolytic anemia. [PDF]
, 2015 Hypereosinophilic syndrome (HES) encompasses numerous diverse conditions resulting in peripheral hypereosinophilia that cannot be explained by hypersensitivity, infection, or atopy and that is not associated with known systemic diseases with specific ...
Brys, Adam K +3 more
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Glial Protein Mutations in Alexander Disease
Pediatric Neurology Briefs, 2005 The role of glial fibrillary acidic protein (GFAP) mutations in Alexander disease was analyzed in 44 patients, including 18 with later onset, at the University of Alabama, Birmingham, AL, and at other centers in the US, UK and Europe.
J Gordon Millichap
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Lithium Decreases Glial Fibrillary Acidic Protein in a Mouse Model of Alexander Disease. [PDF]
PLoS ONE, 2015 Alexander disease is a fatal neurodegenerative disease caused by mutations in the astrocyte intermediate filament glial fibrillary acidic protein (GFAP).
Christine M LaPash Daniels +6 more
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G protein-coupled receptors not currently in the spotlight: free fatty acid receptor 2 and GPR35 [PDF]
, 2017 It is widely appreciated that G protein-coupled receptors have been the most successfully exploited class of targets for the development of small molecule medicines. Despite this, to date, less than 15% of the non-olfactory G protein-coupled receptors in
Milligan, Graeme
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Infantile-Onset Alexander Disease
Pediatric Neurology Briefs, 2012 Researchers at the All India Institute of Medical Sciences, New Delhi, India, and VU University Medical Center, Amsterdam report a 6-year-old Indian boy with infantile-onset Alexander disease having an unusually mild clinical course and a de novo ...
J Gordon Millichap
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MRI diagnosis of Alexander disease
South African Journal of Radiology, 2012 Alexander disease (fibrinoid leucodystrophy; originally described by Alexander in 1949) is a rare, fatal, nonfamilial leucoencephalopathy caused by astrocyte dysfunction characterised by missense mutation in the genes coding for glial fibrillary acidic ...
C G Muralidharan +2 more
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