Results 21 to 30 of about 306,111 (180)

A Case Report of Adult-Onset Alexander Disease with a Tumor-Like Lesion in the Lateral Ventricle

Case Reports in Neurology, 2021
Adult-onset Alexander disease (AOAD) is an autosomal dominant progressive astrogliopathy caused by pathogenic variants in glial fibrillary acidic protein (GFAP).
Tongjia Cai, Sisi Jing, Ying Li, Jianjun Wu   +3 more
doaj   +1 more source

GFAP variant p. Tyr366Cys demonstrated widespread brain cavitation in neonatal Alexander disease.

Radiology Case Reports, 2022
Alexander disease is a rare form of leukodystrophy caused by heterozygous mutations in the gene encoding glial fibrillary acidic protein (GFAP). Brain cavitation in the white matter, predominantly distributed in the frontal periventricular area, has been
Hirokazu Takeuchi, MD, Norimichi Higurashi, MD, PhD, Hiroshi Kawame, MD, PhD, Tadashi Kaname, MD, PhD, Kumiko Yanagi, DDSc, PhD, Yuichiro Nonaka, MD, PhD, Tatsuya Hirotsu, MD, Satoshi Matsushima, MD, PhD, Tetsuya Shimizu, MD, PhD, Taku Gomi, MD, Nei Fukasawa, MD   +10 more
doaj   +1 more source

SARS-CoV-2-Seronegative Subjects Target CTL Epitopes in the SARS-CoV-2 Nucleoprotein Cross-Reactive to Common Cold Coronaviruses

Frontiers in Immunology, 2021
The beta-coronavirus SARS-CoV-2 induces severe disease (COVID-19) mainly in elderly persons with risk factors, whereas the majority of patients experience a mild course of infection.
Katja G. Schmidt, Krystelle Nganou-Makamdop, Matthias Tenbusch, Boutaina El Kenz, Boutaina El Kenz, Clara Maier, Dennis Lapuente, Klaus Überla, Bernd Spriewald, Silke Bergmann, Ellen G. Harrer, Thomas Harrer   +11 more
doaj   +1 more source

Alexander disease GFAP R239C mutant shows increased susceptibility to lipoxidation and elicits mitochondrial dysfunction and oxidative stress

Redox Biology, 2022
Alexander disease is a fatal neurological disorder caused by mutations in the intermediate filament protein Glial Fibrillary Acidic Protein (GFAP), which is key for astrocyte homeostasis.
Álvaro Viedma-Poyatos, Patricia González-Jiménez, María A. Pajares, Dolores Pérez-Sala   +3 more
doaj   +1 more source

Parental Somatic Mosaicism Uncovers Inheritance of an Apparently De Novo GFAP Mutation

Frontiers in Genetics, 2021
Alexander disease is a leukodystrophy caused by heterozygous mutations of GFAP gene. Recurrence in siblings from healthy parents provides a confirmation to the transmission of variants through germinal mosaicism.
Alice Grossi, Federico Morelli, Marco Di Duca, Francesco Caroli, Isabella Moroni, Davide Tonduti, Tiziana Bachetti, Tiziana Bachetti, Isabella Ceccherini   +8 more
doaj   +1 more source

A case report of adult-onset Alexander disease clinically presenting as Parkinson’s disease: is the comorbidity associated with genetic susceptibility?

BMC Neurology, 2020
Background Alexander disease is a rare neurological disease characterized by progressive spastic quadriparesis and bulbar palsy. Moreover, certain patients with adult-onset Alexander disease were often misdiagnosed as other neurodegenerative disorders ...
Jongkyu Park, Sung-Tae Park, Jieun Kim, Kyum-Yil Kwon   +3 more
doaj   +1 more source

Alexander the Great: Head to Head with CTE (Chronic Traumatic Encephalopathy) [PDF]

Athens Journal of History, 2017
One of history’s lingering questions involves the dramatic personality and behavior changes of Alexander the Great. How did a man who was regarded as intelligent, charismatic, compassionate, judicious and composed become increasingly irrational, paranoid,
Alexandra F. Morris
doaj   +1 more source

HDAC inhibitors Panobinostat and Romidepsin enhance tax transcription in HTLV-1-infected cell lines and freshly isolated patients’ T-cells

Frontiers in Immunology, 2022
The viral transactivator Tax plays a key role in HTLV-1 reactivation and de novo infection. Previous approaches focused on the histone deacetylase inhibitor (HDACi) Valproate as a latency-reversing agent to boost Tax expression and expose infected cells ...
Annika P. Schnell, Stephan Kohrt, Aris Aristodemou, Graham P. Taylor, Charles R. M. Bangham, Andrea K. Thoma-Kress   +5 more
doaj   +1 more source

Lithium Decreases Glial Fibrillary Acidic Protein in a Mouse Model of Alexander Disease. [PDF]

PLoS ONE, 2015
Alexander disease is a fatal neurodegenerative disease caused by mutations in the astrocyte intermediate filament glial fibrillary acidic protein (GFAP).
Christine M LaPash Daniels, Elizabeth Paffenroth, Elizabeth V Austin, Konstantin Glebov, Diana Lewis, Jochen Walter, Albee Messing   +6 more
doaj   +1 more source

Randomized controlled trial of the Alexander Technique for idiopathic Parkinson's disease

, 2002
Objective: To determine whether the Alexander Technique, alongside normal treatment, is of benefit to people disabled by idiopathic Parkinson's disease.
Stallibrass, C., Chalmers, C., Sissons, P.   +2 more
core   +1 more source