Results 31 to 40 of about 306,111 (180)

Alexander Disease.

, 2017
Alexander disease is a leukodystrophy caused by dominant missense mutations in the gene encoding the glial fibrillary acidic protein. Individuals with this disorder often present with a typical neuroradiologic pattern including white matter abnormalities with brainstem involvement, selective contrast enhancement, and structural changes to the basal
Tavasoli A, Armangue-Salvador T, Ho CY, Whitehead M, Bornhorst M, Rhee J, Hwang EI, Wells EM, Packer R, van der Knaap MS, Bugiani M, Vanderver A   +11 more
  +5 more sources

Monocytes Elicit a Neutrophil-Independent Th1/Th17 Response Upon Immunization With a Mincle-Dependent Glycolipid Adjuvant

Frontiers in Immunology, 2022
Successful subunit vaccination with recombinant proteins requires adjuvants. The glycolipid trehalose-dibehenate (TDB), a synthetic analog of the mycobacterial cord factor, potently induces Th1 and Th17 immune responses and is a candidate adjuvant for ...
Christiane Desel, Peter J. Murray, Peter J. Murray, Christian H. K. Lehmann, Lukas Heger, Dennis Christensen, Peter Andersen, Matthias Mack, Diana Dudziak, Roland Lang   +9 more
doaj   +1 more source

Retention of skills learnt in Alexander technique lessons: 28 people with idiopathic Parkinson's disease

, 2005
The Alexander technique is a preventive, re-educative, self-help technique for improving the efficiency of overall balance and co-ordination. This paper describes the responses to a questionnaire completed by a sample of 28 people with idiopathic ...
Wentworth, K., Stallibrass, C., Frank, C.   +2 more
core   +1 more source

Modeling Alexander disease with patient iPSCs reveals cellular and molecular pathology of astrocytes [PDF]

, 2016
Alexander disease is a fatal neurological illness characterized by white-matter degeneration and formation of Rosenthal fibers, which contain glial fibrillary acidic protein as astrocytic inclusion.
Misato Funayama, Haruhisa Inoue, Osaka, Hitoshi, Ryosuke Takahashi, Kondo, Takayuki, Takahashi, Ryosuke, Hitoshi Osaka, Tsukita, Kayoko, Miyake, Michiyo, Takumi Era, Michiyo Miyake, Inoue, Haruhisa, Era, Takumi, Ayaki, Takashi, Funayama, Misato, Takayuki Kondo, Kayoko Tsukita, Takashi Ayaki   +17 more
core   +1 more source

Microglia sense astrocyte dysfunction and prevent disease progression in an Alexander disease model. [PDF]

Brain
Saito K, Shigetomi E, Shinozaki Y, Kobayashi K, Parajuli B, Kubota Y, Sakai K, Miyakawa M, Horiuchi H, Nabekura J, Koizumi S.   +10 more
europepmc   +2 more sources

Infantile-Onset Alexander Disease: A Genetically Proven Case With Mild Clinical Course in a 6-Year-Old Indian Boy

, 2013
Alexander disease is an autosomal dominant leukoencephalopathy characterized by developmental delay, macrocephaly, and characteristic neuroimaging abnormalities predominantly involving frontal lobes. We report a 6-year-old Indian boy with infantile-onset
van der Knaap, M.S., Ramesh, Konanki, Sharma, Suvasini, Kumar, Atin, Ramesh, K., Gulati, Sheffali, Salomons, Gajja S., Sharma, S., Gulati, S., van der Knaap, Marjo S., Kumar, A., Salomons, G.S.   +11 more
core   +1 more source

The ocular motor features of adult-onset alexander disease: a case and review of the literature

, 2011
A 51-year-old Chinese man presented with gaze-evoked nystagmus, impaired smooth pursuit and vestibular ocular reflex cancellation, and saccadic dysmetria, along with a family history suggestive of late-onset autosomal dominant parkinsonism.
Jason J S Barton, Barton, Jason J S, Caroli, Francesco, Vertinsky, A Talia, Gerald Pfeffer, A Talia Vertinsky, Pfeffer, Gerald, Isabella Ceccherini, Abegg, Mathias, Mathias Abegg, Ceccherini, Isabella, Francesco Caroli   +11 more
core   +1 more source

Alexander and Canavan Disease

, 2014
How to Cite This Article: Shalbafan B. Alexander and Canavan Disease. Iran J Child Neurol.
SHALBAFAN, Bita
core   +1 more source

Mutations in GFAP Disrupt the Distribution and Function of Organelles in Human Astrocytes

Cell Reports, 2018
Summary: How mutations in glial fibrillary acidic protein (GFAP) cause Alexander disease (AxD) remains elusive. We generated iPSCs from two AxD patients and corrected the GFAP mutations to examine the effects of mutant GFAP on human astrocytes.
Jeffrey R. Jones, Linghai Kong, Michael G. Hanna, IV, Brianna Hoffman, Robert Krencik, Robert Bradley, Tracy Hagemann, Jeea Choi, Matthew Doers, Marina Dubovis, Mohammad Amin Sherafat, Anita Bhattacharyya, Christina Kendziorski, Anjon Audhya, Albee Messing, Su-Chun Zhang   +15 more
doaj   +1 more source

PRIMARY ISOLATION OF NEWCASTLE DISEASE VIRUS IN MDBK CELLINE [PDF]

Journal of Veterinary and Animal Sciences, 1997
Newcastle disease is a dreadful disease of poultry but accurate diagnosis of the disease almost always involves the isolation and characterisation of the virus (Alexander, 1988). For isolation of Newcastle disease virus (NDV) embryonated hens eggs (Beard
Parimal Roy, A.T. Venugopalan, K. Kumanan   +2 more
doaj