Results 71 to 80 of about 84,726 (182)

Rational Design of Alginate Lyase from Microbulbifer sp. Q7 to Improve Thermal Stability

Marine Drugs, 2019
Alginate lyase degrades alginate by the β-elimination mechanism to produce oligosaccharides with special bioactivities. The low thermal stability of alginate lyase limits its industrial application.
Min Yang, Su-Xiao Yang, Zhe-Min Liu, Nan-Nan Li, Li Li, Hai-Jin Mou   +5 more
doaj   +1 more source

Encapsulated Leptin‐Producing Cells Facilitate Entrainment of Circadian Rhythms in Rodents and Nonhuman Primates

Advanced Science, Volume 13, Issue 61, 3 November 2026.
A clinically translatable cell line can be engineered to produce leptin, encapsulated in biomaterial and safely implanted to produce and deliver the metabolic regulating protein within the body. Implantation of these encapsulated cells decreases the time it takes for mice and non‐human primates to adjust to circadian disruptions similar to those ...
Samantha T. Fleury, Xuanyi Lin, Peter D. Rios, Christopher Olker, Eun Joo Song, Alejandra Cobos Perez, Cody Fell, Daisy Lopez, Ira Joshi, Hafsa Nasir, Cecelia Curtis, Danna Muringi, Kaiyuan Wang, José Oberholzer, Fred W. Turek, Isaac B. Hilton, Jonathan Rivnay, Martha Hotz Vitaterna, Omid Veiseh   +18 more
wiley   +1 more source

SiO2–alginate–melittin nano-conjugates suppress the proliferation of ovarian cancer cells: a controlled release approach leveraging alginate lyase

Cancer Nanotechnology
Background Ovarian cancer treatment is challenged by resistance and off-target effects. Melittin shows promise against cancer but is limited by its instability and harmful cellular interactions. Our study introduces SiO2–alginate–melittin nano-conjugates
Lihui Si, Shuli Yang, Ruixin Lin, Shiyu Gu, Chuhan Yan, Jia Yan   +5 more
doaj   +1 more source

Pectinase‐Based Bioprocesses for Circular Bioeconomy and Sustainable Industrial Development

Biotechnology and Bioengineering, Volume 123, Issue 11, Page 2906-2936, November 2026.
This picture demonstrates a unified strategy for sustainable pectinase production, focusing on microbial bioproduction, innovative strategies in enzyme engineering (Protein engineering, rational enzyme design, directed evolution and heterologous expression) and various applications in industry, including food, textiles, pulp and paper, agriculture and ...
Nisha Sharma, Dimple Tanwar, Usha Grewal, Murugesan Mohana Keerthi, Yogesh K. Ahlawat, Nitin Pandey, Chirag G. Makvana   +6 more
wiley   +1 more source

Functional Characterization of a Novel Oligoalginate Lyase of Stenotrophomonas maltophilia KJ-2 Using Site-Specific Mutation Reveals Bifunctional Mode of Action, Possessing Both Endolytic and Exolytic Degradation Activity Toward Alginate in Seaweed Biomass

Frontiers in Marine Science, 2020
A novel oligoalginate lyase from the marine bacterium, Stenotrophomonas maltophilia KJ-2, completely depolymerizes alginate to monomers with generation of oligomer intermediates.
Yoo Jung Chu, Hae Sol Kim, Myung Sun Kim, Eun Yeol Lee, Hee Sook Kim   +4 more
doaj   +1 more source

Structural basis for controlling the enzymatic properties of polymannuronate preferred alginate lyase FlAlyA from the PL-7 family

, 2018
Alginate-recognition subsites of alginate lyase FlAlyA were characterized as potential targets for engineering alginate oligosaccharides that are useful biomaterials.
Ryuji Nishiyama, Akira Nakamura, Akira Inoue, Hui-Min Qin, Takuya Miyakawa, Takao Ojima, Masaru Tanokura, Atsuko Asano   +7 more
core   +1 more source

Functional And Structural Studies Of Alginate Lyase From Persicobacter sp. CCB-QB2 [PDF]

, 2017
AlyQ gene from Persicobacter sp.CCB-QB2encodes alginate lyase which is comprised of two carbohydrate-bindingdomains, domains A and B,at the N-terminus of the alginate lyase domain, domain C.
Sim, Pei Fang
core   +1 more source

A guide to the ecological limitations of phage therapy of bacterial biofilms: Is what's best for the phage best for the physician?

The FEBS Journal, Volume 293, Issue 21, Page 6293-6307, November 2026.
Bacteriophages—viruses that kill bacteria—are promising weapons against bacterial biofilms: sessile communities notoriously resistant to antibiotics. Yet phages evolved not so much to eradicate bacteria as to obtain new bacteria to infect. That goal, however, may conflict with the physician's objective of complete bacterial clearance.
Stephen T. Abedon
wiley   +1 more source

Alginate Lyase and Its Applications in Alginate Oligosaccharides Production

Food Reviews International
In recent years, marine resources become strategic resources and attract widespread attention due to their unique physiological and physiochemical properties. Alginate, a prominent marine polysaccharide, is derived from the cell walls of brown algae and certain bacteria.
Zhang, Wenli, Yang, Junya, Liu, Xiaoyong, Zhu, Yingying, Xu, Wei, Ni, Dawei, Petrova, Penka, Petrov, Kaloyan, Mu, Wanmeng   +8 more
openaire   +1 more source

Micro/Nanostructured Materials and Microfluidic Diagnostic Platforms Enable Multimodal Detection of Circulating Tumor Cells

Exploration, Volume 6, Issue 5, October 2026.
Engineered micro/nanomaterials enable high‐efficiency CTC capture, release, and multimodal molecular profiling. Integrated with AI‐driven analytics, these platforms decode tumor heterogeneity and metastatic dynamics, advancing real‐time monitoring and precision oncology through DNA, RNA, and protein cross‐scale data fusion.
Hao Li, Jiaojiao Sun, Kunguo Liu, Shijie Wang, Bowen Fu, Hong Zhu, Peng Cao, Xin Han   +7 more
wiley   +1 more source