Results 71 to 80 of about 1,725,284 (283)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Complexity, Governance and Networks: Introduction to the Inaugural Issue
, 2014 From the introduction: 1. Yet Another Journal? Why is it necessary to publish a new journal about complexity, governance, and networks? There has been an increasing interest in complexity, governance, and network studies in recent decades.
Morçöl, Göktuğ +2 more
core +1 more source
An Additively Optimal Interpreter for Approximating Kolmogorov Prefix Complexity
EntropyWe study practical approximations of Kolmogorov prefix complexity (K) using IMP2, a high-level programming language. Our focus is on investigating the optimality of the interpreter for this language as the reference machine for the Coding Theorem Method (
Zoe Leyva-Acosta +2 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
What makes a “regime complex” complex? It depends
, 2021 What makes the collections of international institutions or regimes governing various domains—called in theliterature regime, institutional, or governance complexes—“complex”?
Hollway, James
core +1 more source
International Journal of Information and Communication Technology Research, 2011 In this paper، we propose a new algorithm of spectrum sensing based on algorithmic information theory. Since the proposed algorithm is applied in time domain، resulting in an overall reduction on the system computational complexity.
Saeid Balaneshin Kordan +1 more
doaj
Backbone colouring and algorithms for TDMA scheduling [PDF]
Discrete Mathematics & Theoretical Computer Science, 2019 We investigate graph colouring models for the purpose of optimizing TDMA link scheduling in Wireless Networks. Inspired by the BPRN-colouring model recently introduced by Rocha and Sasaki, we introduce a new colouring model, namely the BMRN-colouring ...
Julien Bensmail +4 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source