Results 41 to 50 of about 4,116,478 (294)
PathMe: merging and exploring mechanistic pathway knowledge
BMC Bioinformatics, 2019 Background The complexity of representing biological systems is compounded by an ever-expanding body of knowledge emerging from multi-omics experiments.
Daniel Domingo-Fernández +4 more
doaj +1 more source
ADataViewer: exploring semantically harmonized Alzheimer’s disease cohort datasets
Alzheimer’s Research & Therapy, 2022 Background Currently, Alzheimer’s disease (AD) cohort datasets are difficult to find and lack across-cohort interoperability, and the actual content of publicly available datasets often only becomes clear to third-party researchers once data access has ...
Yasamin Salimi +5 more
doaj +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi +5 more
wiley +1 more source
IEEE Access, 2020 We propose a novel equivalent model for a quantizer with noisy input (the desired signal corrupted by measurement noise). It presents the quantizer output as a sum of the desired signal after it passes through a nonlinear element with a known equivalent ...
Arkady Molev-Shteiman +4 more
doaj +1 more source
Algorithms for entanglement renormalization [PDF]
, 2009 We describe an iterative method to optimize the multi-scale entanglement renormalization ansatz (MERA) for the low-energy subspace of local Hamiltonians on a D-dimensional lattice.
G. Evenbly +4 more
core +2 more sources
Current Developments in Mathematics, 2005 Leslie Valiant recently proposed a theory of holo- graphic algorithms. These novel algorithms achieve exponential speed-ups for certain computational problems compared to naive algorithms for the same problems. The methodology uses Pfaffians and (planar) perfect matchings as basic computational primitives, and attempts to create exponential ...
openaire +2 more sources
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
A note on compact and compact circular edge-colorings of graphs [PDF]
Discrete Mathematics & Theoretical Computer Science, 2008 Graphs and ...
Dariusz Dereniowski, Adam Nadolski
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
BMC Bioinformatics, 2020 Background During the last decade, there has been a surge towards computational drug repositioning owing to constantly increasing -omics data in the biomedical research field. While numerous existing methods focus on the integration of heterogeneous data
Mohammad Asif Emon +3 more
doaj +1 more source