Results 51 to 60 of about 2,582,277 (310)

Quantifying mechanisms in neurodegenerative diseases (NDDs) using candidate mechanism perturbation amplitude (CMPA) algorithm

BMC Bioinformatics, 2019
Background Literature derived knowledge assemblies have been used as an effective way of representing biological phenomenon and understanding disease etiology in systems biology.
Reagon Karki, Alpha Tom Kodamullil, Charles Tapley Hoyt, Martin Hofmann-Apitius   +3 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Algorithms and Their Explanations [PDF]

, 2014
By analysing the explanation of the classical heapsort algorithm via the method of levels of abstraction mainly due to Floridi, we give a concrete and precise example of how to deal with algorithmic knowledge. To do so, we introduce a concept already implicit in the method, the ‘gradient of explanations’.
BENINI, MARCO, GOBBO, FEDERICO
openaire   +4 more sources

Leveraging Machine Learning for Weed Management and Crop Enhancement: Vineyard Flora Classification [PDF]

The global population’s rapid growth necessitates a 70% increase in agricultural production, posing challenges exacerbated by weed infestation and herbicide drawbacks.
Alibabaei, Khadijeh, Corceiro, Ana, Pereira, Nuno José Matos, Gaspar, Pedro Dinis   +3 more
core   +1 more source

Progressive geometric algorithms [PDF]

, 2014
Progressive algorithms are algorithms that, on the way to computing a complete solution to the problem at hand, output intermediate solutions that approximate the complete solution increasingly well.
Alewijnse, SPA Sander, Buchin, KA Kevin, Alex P. ten Brink, Bagautdinov, T.M., Bouts, Q.W., de Berg, M.T., Buchin, K.A., M. de Berg, Bagautdinov, TM Timur, Westenberg, M.A., Alewijnse, Sander P.A., Ten Brink, A. P., Mark de Berg, Alewijnse, S.P.A., Michel A. Westenberg, Buchin, K., M. A. Westenberg, S. P. A. Alewijnse, de Berg, Mark, Bouts, Q. W., A. P. ten Brink, Brink, AP Alex ten, Bagautdinov, T. M., de Berg, M.T.; id_orcid, Brink, ten, A.P., Berg, MT Mark de, Westenberg, M. A., De Berg, M., Buchin, Kevin, Sander P.A. Alewijnse, Kevin Buchin, Bagautdinov, Timur M., T. M. Bagautdinov, Bouts, QW Quirijn, Westenberg, Michel A., Westenberg, MA Michel, Alewijnse, S. P. A., Berg, de, M.T., Timur M. Bagautdinov, Q. W. Bouts, K. Buchin, Bouts, Quirijn W., ten Brink, Alex P., Berg, de, M.T.; id_orcid, Quirijn W. Bouts   +44 more
core   +3 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

KOALA GRAPH THEORY INTERNET SERVICE

TASK Quarterly, 2015
KOALA has been created with the idea of C++ library templates, implementing a broad set of procedures in the fields of algorithmic graph theory and network problems in discrete optimization.
TOMASZ GOLUCH, KRZYSZTOF M. OCETKIEWICZ, KRZYSZTOF GIARO   +2 more
doaj   +1 more source

Comparison and aggregation of event sequences across ten cohorts to describe the consensus biomarker evolution in Alzheimer’s disease

Alzheimer’s Research & Therapy, 2022
Background Previous models of Alzheimer’s disease (AD) progression were primarily hypothetical or based on data originating from single cohort studies. However, cohort datasets are subject to specific inclusion and exclusion criteria that influence the ...
Sepehr Golriz Khatami, Yasamin Salimi, Martin Hofmann-Apitius, Neil P. Oxtoby, Colin Birkenbihl, for the Alzheimer’s Disease Neuroimaging Initiative, the Japanese Alzheimer’s Disease Neuroimaging Initiative, the Alzheimer’s Disease Repository Without Borders Investigators   +7 more
doaj   +1 more source

Analysis of Algorithms and Partial Algorithms [PDF]

, 2016
We present an alternative methodology for the analysis of algorithms, based on the concept of expected discounted reward. This methodology naturally handles algorithms that do not always terminate, so it can (theoretically) be used with partial algorithms for undecidable problems, such as those found in artificial general intelligence (AGI) and ...
openaire   +3 more sources

Algorithmic thermodynamics [PDF]

Mathematical Structures in Computer Science, 2012
Algorithmic entropy can be viewed as a special case of the entropy studied in statistical mechanics. This viewpoint allows us to apply many techniques developed for use in thermodynamics to the subject of algorithmic information theory. In particular, suppose we fix a universal prefix-free Turing machine and letXbe the set of programs that halt for ...
John C. Baez, Mike Stay
openaire   +5 more sources