Results 51 to 60 of about 4,174,426 (295)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
, 2017 For genetic algorithms using a bit-string representation of length~$n$, the general recommendation is to take $1/n$ as mutation rate. In this work, we discuss whether this is really justified for multimodal functions. Taking jump functions and the $(1+1)$
Doerr, Benjamin +3 more
core +1 more source
Evaluating Data Assimilation Algorithms [PDF]
, 2012 Data assimilation leads naturally to a Bayesian formulation in which the posterior probability distribution of the system state, given the observations, plays a central conceptual role.
A. M. Stuart +68 more
core +3 more sources
, 2022 Why not have a computer just draw a map? This is something you hear a lot when people talk about gerrymandering, and it's easy to think at first that this could solve redistricting altogether. But there are more than a couple problems with this idea. In this chapter, two computer scientists survey what's been done in algorithmic redistricting, discuss ...
Amariah Becker, Justin Solomon 0001
openaire +2 more sources
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
BMC Bioinformatics, 2020 Background During the last decade, there has been a surge towards computational drug repositioning owing to constantly increasing -omics data in the biomedical research field. While numerous existing methods focus on the integration of heterogeneous data
Mohammad Asif Emon +3 more
doaj +1 more source
Molecular Oncology, Volume 20, Issue 6, Page 1513-1534, June 2026.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
BMC Bioinformatics, 2019 Background Literature derived knowledge assemblies have been used as an effective way of representing biological phenomenon and understanding disease etiology in systems biology.
Reagon Karki +3 more
doaj +1 more source
The Computer Journal, 1987 Algorithms are derived for allocating and deallocating blocks of memory using binary buddy, weighted buddy and variant weighted buddy partitioning; and transformations are demonstrated for converting recursive into non-recursive forms. Algorithms are given for the relatively difficult computation of the addressed and size of a buddy slot in the ...
D. J. Challab, J. D. Roberts
openaire +2 more sources
Molecular Oncology, Volume 20, Issue 6, Page 1494-1512, June 2026.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source