Results 51 to 60 of about 2,274,451 (319)

The Elements of Flexibility for Task-Performing Systems

open access: yesIEEE Access, 2023
What makes living systems flexible so that they can react quickly and adapt easily to changing environments? This question has not only engaged biologists for decades but is also of great interest to computer scientists and engineers who seek inspiration
Sebastian Mayer   +2 more
doaj   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

open access: yesMolecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian   +10 more
wiley   +1 more source

Algorithms, Algorithms, Algorithms [PDF]

open access: yesComputer, 2020
James Bret Michael, Jeffrey Voas
openaire   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

Variational quantum generative modeling by sampling expectation values of tunable observables

open access: yesnpj Quantum Information
Expectation Value Samplers (EVSs) are quantum generative models that can learn high-dimensional continuous distributions by measuring the expectation values of parameterized quantum circuits. However, these models can demand impractical quantum resources
Kevin Shen   +5 more
doaj   +1 more source

On minimal blocking sets of the generalized quadrangle $Q(4, q)$ [PDF]

open access: yesDiscrete Mathematics & Theoretical Computer Science, 2005
The generalized quadrangle $Q(4,q)$ arising from the parabolic quadric in $PG(4,q)$ always has an ovoid. It is not known whether a minimal blocking set of size smaller than $q^2 + q$ (which is not an ovoid) exists in $Q(4,q)$, $q$ odd. We present results
Miroslava Cimráková, Veerle Fack
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

open access: yesMolecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert   +13 more
wiley   +1 more source

Packing Three-Vertex Paths in a Subcubic Graph [PDF]

open access: yesDiscrete Mathematics & Theoretical Computer Science, 2005
In our paper we consider the $P_3$-packing problem in subcubic graphs of different connectivity, improving earlier results of Kelmans and Mubayi. We show that there exists a $P_3$-packing of at least $\lceil 3n/4\rceil$ vertices in any connected subcubic
Adrian Kosowski   +2 more
doaj   +1 more source

Algorithmic polynomials [PDF]

open access: yesProceedings of the 50th Annual ACM SIGACT Symposium on Theory of Computing, 2018
The approximate degree of a Boolean function $f(x_{1},x_{2},\ldots,x_{n})$ is the minimum degree of a real polynomial that approximates $f$ pointwise within $1/3$. Upper bounds on approximate degree have a variety of applications in learning theory, differential privacy, and algorithm design in general.
openaire   +3 more sources

Algorithmic thermodynamics [PDF]

open access: yesMathematical Structures in Computer Science, 2012
Algorithmic entropy can be viewed as a special case of the entropy studied in statistical mechanics. This viewpoint allows us to apply many techniques developed for use in thermodynamics to the subject of algorithmic information theory. In particular, suppose we fix a universal prefix-free Turing machine and letXbe the set of programs that halt for ...
BAEZ, JOHN, STAY, MIKE
openaire   +4 more sources

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