Results 51 to 60 of about 5,408,588 (346)

Self-Improving Algorithms

open access: yes, 2010
We investigate ways in which an algorithm can improve its expected performance by fine-tuning itself automatically with respect to an unknown input distribution D. We assume here that D is of product type.
Ailon, Nir   +5 more
core   +2 more sources

Complementary Algorithms For Tableaux [PDF]

open access: yes, 2000
We study four operations defined on pairs of tableaux. Algorithms for the first three involve the familiar procedures of jeu de taquin, row insertion, and column insertion.
Roby, Tom   +3 more
core   +3 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Symbolic Quantitative Information Flow [PDF]

open access: yes, 2012
acmid: 2382791 issue_date: November 2012 keywords: algorithms, security, verification numpages: 5acmid: 2382791 issue_date: November 2012 keywords: algorithms, security, verification numpages: 5acmid: 2382791 issue_date: November 2012 keywords ...
Malacaria, P   +3 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Quantifying mechanisms in neurodegenerative diseases (NDDs) using candidate mechanism perturbation amplitude (CMPA) algorithm

open access: yesBMC Bioinformatics, 2019
Background Literature derived knowledge assemblies have been used as an effective way of representing biological phenomenon and understanding disease etiology in systems biology.
Reagon Karki   +3 more
doaj   +1 more source

A machine learning method for the identification and characterization of novel COVID-19 drug targets

open access: yesScientific Reports, 2023
In addition to vaccines, the World Health Organization sees novel medications as an urgent matter to fight the ongoing COVID-19 pandemic. One possible strategy is to identify target proteins, for which a perturbation by an existing compound is likely to ...
Bruce Schultz   +8 more
doaj   +1 more source

Random local algorithms [PDF]

open access: yes, 2012
Consider the problem when we want to construct some structure on a bounded degree graph, e.g. an almost maximum matching, and we want to decide about each edge depending only on its constant radius neighbourhood.
Csóka, Endre
core  

Optimal Distributed Covering Algorithms [PDF]

open access: yes, 2019
We present a time-optimal deterministic distributed algorithm for approximating a minimum weight vertex cover in hypergraphs of rank f. This problem is equivalent to the Minimum Weight Set Cover problem in which the frequency of every element is bounded ...
Ben-Basat, Ran   +3 more
core   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

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