Results 61 to 70 of about 9,995,501 (376)

Quantifying mechanisms in neurodegenerative diseases (NDDs) using candidate mechanism perturbation amplitude (CMPA) algorithm

BMC Bioinformatics, 2019
Background Literature derived knowledge assemblies have been used as an effective way of representing biological phenomenon and understanding disease etiology in systems biology.
Reagon Karki, Alpha Tom Kodamullil, Charles Tapley Hoyt, Martin Hofmann-Apitius   +3 more
doaj   +1 more source

A machine learning method for the identification and characterization of novel COVID-19 drug targets

Scientific Reports, 2023
In addition to vaccines, the World Health Organization sees novel medications as an urgent matter to fight the ongoing COVID-19 pandemic. One possible strategy is to identify target proteins, for which a perturbation by an existing compound is likely to ...
Bruce Schultz, Lauren Nicole DeLong, Aliaksandr Masny, Manuel Lentzen, Tamara Raschka, David van Dijk, Andrea Zaliani, COPERIMOplus, Holger Fröhlich   +8 more
doaj   +1 more source

Fast Genetic Algorithms

, 2017
For genetic algorithms using a bit-string representation of length~$n$, the general recommendation is to take $1/n$ as mutation rate. In this work, we discuss whether this is really justified for multimodal functions. Taking jump functions and the $(1+1)$
Doerr, Benjamin, Le, Huu Phuoc, Makhmara, Régis, Nguyen, Ta Duy   +3 more
core   +1 more source

Complementary Algorithms For Tableaux [PDF]

, 2000
We study four operations defined on pairs of tableaux. Algorithms for the first three involve the familiar procedures of jeu de taquin, row insertion, and column insertion.
Roby, Tom, Sottile, Frank, Stroomer, Jeffrey, West, Julian   +3 more
core   +3 more sources

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

FEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker, Nimit Mistry, Nicoletta Plotegher, Elizabeth R. Westbrook, Michael D. E. Sewell, John Carroll, Gyorgy Szabadkai, Angus J. Bain, Michael R. Duchen   +8 more
wiley   +1 more source

Comparison and aggregation of event sequences across ten cohorts to describe the consensus biomarker evolution in Alzheimer’s disease

Alzheimer’s Research & Therapy, 2022
Background Previous models of Alzheimer’s disease (AD) progression were primarily hypothetical or based on data originating from single cohort studies. However, cohort datasets are subject to specific inclusion and exclusion criteria that influence the ...
Sepehr Golriz Khatami, Yasamin Salimi, Martin Hofmann-Apitius, Neil P. Oxtoby, Colin Birkenbihl, for the Alzheimer’s Disease Neuroimaging Initiative, the Japanese Alzheimer’s Disease Neuroimaging Initiative, the Alzheimer’s Disease Repository Without Borders Investigators   +7 more
doaj   +1 more source

Self-Improving Algorithms

, 2010
We investigate ways in which an algorithm can improve its expected performance by fine-tuning itself automatically with respect to an unknown input distribution D. We assume here that D is of product type.
Ailon, Nir, Chazelle, Bernard, Clarkson, Kenneth L., Liu, Ding, Mulzer, Wolfgang, Seshadhri, C.   +5 more
core   +2 more sources

Optimal Distributed Covering Algorithms [PDF]

, 2019
We present a time-optimal deterministic distributed algorithm for approximating a minimum weight vertex cover in hypergraphs of rank f. This problem is equivalent to the Minimum Weight Set Cover problem in which the frequency of every element is bounded ...
Ben-Basat, Ran, Even, Guy, Kawarabayashi, Ken-ichi, Schwartzman, Gregory   +3 more
core   +2 more sources

Analysis of Algorithms and Partial Algorithms [PDF]

, 2016
We present an alternative methodology for the analysis of algorithms, based on the concept of expected discounted reward. This methodology naturally handles algorithms that do not always terminate, so it can (theoretically) be used with partial algorithms for undecidable problems, such as those found in artificial general intelligence (AGI) and ...
openaire   +3 more sources

Algorithms and Regulation [PDF]

, 2021
New technologies have always challenged the social, economic, legal, and ideological status quo. Constitutional law is no less impacted by such technologically driven transformations, as the state must formulate a legal response to new technologies and their market applications, as well as the state’s own use of new technology.
Reichman, Amnon, Sartor, Giovanni
openaire   +2 more sources